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Noradrenaline-Induced Lipolysis in Adipose Tissue is Suppressed at Hibernation Temperatures in Ground Squirrels (2003)

Dark, J. ; Miller, D. R. ; Lewis, D. A. ; [et al.]

Oxford, UK : Blackwell Science, Ltd

Journal of neuroendocrinology 15 (2003), S. 0

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ISSN: 1365-2826

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Responsiveness of white adipose tissue (WAT) and brown adipose tissue (BAT) from hibernating and nonhibernating golden-mantled ground squirrels (Spermophilus lateralis) to the lipolytic action of the sympathetic neurotransmitter, noradrenaline, was tested in vitro at temperatures characteristic of deep torpor (5 °C) and euthermia (37 °C). Noradrenaline-stimulated lipolysis, as indicated by WAT glycerol release, of tissue from hibernating ground squirrels was six- to ten-fold greater at 37 °C than at 5 °C. Noradrenaline was ineffective in increasing lipolysis at 5 °C. Noradrenaline-stimulated lipolysis in BAT was similarly suppressed at 5 °C. Noradrenaline-stimulated lipolysis was little affected by temperature change below approximately 15 °C but strongly correlated with temperature above approximately 15 °C. Noradrenaline-induced lipolysis of WAT from nonhibernating and hibernating ground squirrels did not differ at an incubation temperature of 5 °C. We conclude that noradrenaline-stimulated WAT lipolytic activity is markedly suppressed at the low temperatures characteristic of deep torpor and that there is no ‘hibernation-specific’ adaptation of WAT to enhance its responsiveness to noradrenaline at low tissue temperatures. Temperature dependence of noradrenaline-stimulated lipolysis may in part account for the shift from lipid to carbohydrate metabolism during the earliest stage of arousal from deep torpor.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-2826.2003.01020.x

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Dihydrodiol Formation from Indanones in Rats and Rabbits (1966)

LEWIS, D. A.

[s.l.] : Nature Publishing Group

Nature 210 (1966), S. 1046-1047

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] In the present investigation indan-2-one was prepared by the distillation of o-phenylene-diacetic acid. The product was purified by steam distillation. Indan-1-one was obtained from Kodak, Ltd., London. ( ± )cis-Indane-1,2-diol (m.p. 98-99 ° C) and (± )£ram?-indane-l,2-diol ...