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  • 2000-2004  (1)
  • 1960-1964  (2)
  • 1945-1949
  • Organic Chemistry  (2)
  • hyperthermia  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Heat Shock Response is Associated with Protection Against Acute Interstitial Pancreatitis in Rats (2000)
    Springer
    Digestive diseases and sciences 45 (2000), S. 2252-2264 
    Details
    ISSN: 1573-2568
    Keywords: cerulein pancreatitis ; dibutyltin dichloride ; cytoprotection ; heat shock protein ; hyperthermia ; transforming growth factor-β1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We recently reported that hyperthermia induces pancreatic expression of heat shock proteins (HSPs), particularly HSP70 isoforms, and protects against cerulein pancreatitis. We have now studied whether a double hyperthermia amplifies these effects and whether hyperthermia also protects against dibutyltin dichloride (DBTC)-induced pancreatitis. A further aim was to examine whether hyperthermia induces changes in transforming growth factor-β1 (TGF-β1). Following pretreatment without or with a single or double hyperthermia, pancreatitis was induced by application of cerulein or DBTC. Pancreatic HSP and TGF-β1 expression were studied by immunoblotting. Pancreas injury was assessed by light microscopy and serum pancreatic enzyme activity. Hyperthermia as well as DBTC induced HSP72, whereas cerulein did not. A double hyperthermia led to a further increase in HSP72 compared to a single heat stress. In both models, hyperthermia significantly reduced pancreatic injury. Although a double hyperthermia slightly decreased the severity of cerulein pancreatitis compared to a single heat treatment, an improved pancreas protection against DBTC cytotoxicity was not achieved. We also found that hyperthermia induces the expression of TGF-β1. In conclusion, hyperthermia preconditioning exerts protective effects against two pathophysiologically different types of pancreatitis by a mechanism that involves the up-regulation of HSP70 isoforms as well as TGF-β1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026459001195
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die Strukturen der mittleren Ringverbindungen. VII. 1,6-trans-Dibromcyclodecan (1964)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 47 (1964), S. 951-956 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Crystals of 1,6-trans-dibromcyclodecane are monoclinic, a = 7,94, b =5,65, c = 12,78 A, β = 106° 47′, space group P2, lc. The unit cell contains two centrosymmetric molecules. The crystal structure has been determined by analysis of the three prin- cipal projections. The ring skeleton has the same conformation as that found in all previously studied cyclodecane compounds, with the substituents in (IIe, IIe) positions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19640470406
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Die Strukturen der mittleren Ringverbindungen VIII. Azacyclododecan-hydrochlorid (1964)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 47 (1964), S. 1138-1147 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Crystals of azacyclododecane hydrochloride (a = 13.77, b = 5.07, c = 9.67 Å, α = 109°26′, β = 90°22′, γ = 101°16′) and hydrobromide (a = 13.53, b = 5.19, c = 9.45 Å, α = 99°40′, β = 83°57′, γ = 98°28′) are isomorphous, space group P1, Z = 2. The conformation of the 12-membered ring has been established from three-dimensional X-ray analysis. It corresponds closely to the idealized model with 422-symmetry, containing 8 syn-clinal and 4 anti-periplanar partial conformations.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19640470504
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    Paper (German National Licenses)
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