ISSN:
1573-904X
Keywords:
compression
;
ultrasound
;
pharmaceutical powder compression
;
tableting
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The use of ultrasound during the tableting of pharmaceutical powders is a new concept. However, in themetallurgy, plastic, and ceramic industries, ultrasound-assisted compression of materials has been knownfor some years. Ultrasound improves the characteristics of the compression process leading to optimizedmechanical strength of the compacts without applying excessive compression force. Therefore, problemsassociated with high-pressure compression in tableting can be overcome and tablets may be manufacturedmore economically and consistently with the aid of ultrasound compared to conventional pressureprocesses. Although great progress in the theoretical understanding of the ultrasound-assisted powdercompression process has been made since the late 1960s, the need for further research in the area of ultrasoundapplication during pharmaceutical powder compression is essential. Further investigations on a wide rangeof drugs and excipients, to expand the usefulness and scope of the ultrasound-assisted technique, and tounderstand the complex phenomena involved in the process, are needed. In this article the principles,advantages, and limitations of the application of ultrasonic vibrations during pharmaceutical powdercompression is reviewed with the hope that this article can contribute to, and stimulate research in the area.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007540703955
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