ISSN:
1569-8041
Keywords:
adolescence
;
B-cell lymphoma
;
Burkitt's lymphoma
;
child
;
large-cell lymphoma
;
non-Burkitt lymphoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background:The Revised European–American Lymphoma(R.E.A.L.) Classification criteria were evaluated in the internationalprotocol FAB LMB 96 Treatment of Mature B-Cell Lymphoma/Leukemia: A SFOP LMB96/CCG-5961/UKCCSG NHL 9600 Cooperative Study. This includes B-lineagelymphomas: Burkitt's lymphoma (including ALL-L3); high-grade B-cell lymphoma,Burkitt-like; diffuse large B-cell lymphoma (excluding anaplastic large cellKi-1 lymphoma). Patients and methods:Cases were independently reviewed by eighthematopathologists from the three cooperative national groups (two SFOP, twoCCG, four UKCCSG), without prior discussion of classification criteria orguidelines for case rejection. Consensus diagnosis was determined by eachnational cooperative group, and final consensus diagnosis established when atleast two national consensus diagnoses were in agreement, or following groupagreement at a multiheaded microscope. Results:Two hundred eight cases were reviewed, with finalconsensus diagnosis established in two hundred three. The percent agreementof each group's national consensus diagnosis with final consensus diagnosiswas 86%, 86% and 71%. The percent agreement of thegroup's national consensus diagnosis with final consensus diagnosis forBurkitt's and diffuse large B-cell lymphoma were 88% and 80%,respectively, but only 42% for Burkitt-like lymphoma. Conclusions:International panel review of mature B-celllymphoma/leukemia in children and adolescents highlighted difficulties insubclassification, particularly with Burkitt-like, which is a 'provisionalentity' in the R.E.A.L. Classification. The absence of previous discussion ofclassification and guidelines for case rejection may in part explain thediscrepancy between pathologists. These results underline that morphology mayneed to be complemented by other studies, such as molecular genetics andcytogenetics, to discriminate between the mature B-cell lymphomas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008304329943
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