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  • 2000-2004  (4)
  • 1960-1964  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    ENZYMATIC SYNTHESIS OF THEAFLAVINS AND EPITHEAFLAVIC ACID FROM TEA CATECHINS AND THEIR ANTIOXIDANT ACTIVITY (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food lipids 11 (2004), S. 0 
    Details
    ISSN: 1745-4522
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: A number of in vitro and in vivo studies have demonstrated that black tea polyphenols have significant biological activities, including antioxidant, antiinflammatory and anticancer activity. The theaflavins have received attention as one of responsible components for biological activities of black tea. However, little information is available for the biological activity of individual theaflavins and minor components in black tea. In the present study, theaflavins and epitheqflavic acid were synthesized from their parent flavan-3-ols catechins using an enzymatic oxidation method and employing crude polyphenol oxidase from banana fruit. The compounds were isolated using column chromatographic methods, and their structures confirmed by 1H-NMR and APCI-MS. The peroxyl radical scavenging activities of theaflavins and epitheaflavic acids were measured using a modified ORAC method. The results indicated that theaflavins have higher peroxyl radical scavenging activity than EGCG. The hierarchy of radical scavenging activity of theaflavins, epitheaflavic acid and related compounds were in the order of: theaflavin-3, 3′-digallate ∼ theflavin-3-gallate ∼ theaflavin-3′-gallate ∼ theaflavin 〉 epitheaflavic acid 〉 EGCG 〉 purpurogallin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4522.2004.tb00263.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Solar keratoses: Analysis in a dermatological practice in Australia (2003)
    Oxford, UK : Blackwell Science Pty
    Australasian journal of dermatology 44 (2003), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two hundred consecutive patients with solar keratoses (SK) seen in a private dermatology practice had on average 61.9 SK compared with eight reported in the general population. Non-melanoma skin cancer was present in 41% of patients and 17% had squamous cell carcinoma (SCC). The ratio of basal cell carcinoma to SCC in the cohort was 1.7:1. The commonest site of SK was the upper limbs but the greatest density of lesions was on the face, particularly the nose. Squamous cell carcinomas were most commonly found on the upper and lower limbs. Basal cell carcinomas were most common on the head and neck.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-0960.2002.00634.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Efficacy, cutaneous tolerance and cosmetic acceptability of desonide 0.05% lotion (Desowen®) versus vehicle in the short-term treatment of facial atopic or seborrhoeic dermatitis (2002)
    Oxford, UK : Blackwell Science Pty
    Australasian journal of dermatology 43 (2002), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The differences between topical corticosteroids are based mainly on their potency, safety and patient acceptability. The aim of this study was to evaluate a mild- to mid-potent topical corticosteroid, desonide 0.05%, on these three parameters in an Australian cohort of patients with facial seborrhoeic or atopic dermatitis. Eighty-one adult patients were randomized to receive desonide 0.05% lotion or its vehicle, applied twice daily for 3 weeks under double-blind conditions. In the active treatment group, 88% of patients had their skin condition cleared or almost cleared and only two patients experienced cutaneous adverse events (rash and pruritus). The acceptability of the lotion was high; 95% of patients stated they would use this topical corticosteroid again. These data support the short-term use of desonide 0.05% lotion as a suitable agent for the short-term treatment of facial dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-0960.2002.00592.x
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  • 4
    Electronic Resource
    Electronic Resource
    ANTIOXIDATIVE FLAVONOID GLYCOSIDES FROM QUINOA SEEDS (CHENOPODIUM QUINOA WILLD) (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food lipids 8 (2001), S. 0 
    Details
    ISSN: 1745-4522
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Six flavonol glycosides have been isolated from quinoa seeds (Chenopodium quinoa Willd) via normal phase and reverse phase column chromatography. On the basis of spectral data, their structures were established as kaempferol 3-O-[β-D-apiofuranosyl(1′–2″)]-β-D-galactopyranoside (1), kaempferol 3-O-[α-L-rhamnopyranosyl(1″–2″)]-β-D-galactopyranoside (2), kaempferol 3-O-[β-D-apiofuranosyl(1′–2″)-α-L-rhamnopyranosyl(1″–6″)]-β-D-galactopyranoside (3), kaempferol 3-O-(2,6-di-α-L-rhamnopyranosyl)-β-D-galactopyranoside (4), quercetin 3-O-[β-D-apiofuranosyl (1′–2″)-α-L-rhamnopyranosyl(1″–6″)]-β-D-galactopyranoside (5) and quercetin 3-O-(2,6-di-α-L-rhamnopyranosyl)-β-D-galactopyranoside (6). Among them, compounds 1, 4 and 6 were the main flavonoid glycosides found in quinoa seeds and compounds 2, 5, and 6 were isolated from this plant for the first time. All six compounds exhibited antioxidant
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4522.2001.tb00182.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Abstract biological systems as sequential machines (1964)
    Springer
    Bulletin of mathematical biology 26 (1964), S. 103-111 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract It is shown that a rather close relationship exists between the (ℳ,ℛ)-systems, defined previously as prototypes of abstract biological systems, and the sequential machines which have been studied by various authors. The theory of sequential machines is reformulated in a way suitable for its application to the study of the intertransformability of (ℳ,ℛ)-systems as a result of environmental alteration. The important concept of strong connectedness is most useful in this direction, and is used to derive a number of results on intertransformability. Some suggestions are made for further studies along these lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476831
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    An hypothesis of freese and the DNA-protein coding problem (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 305-318 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Freese’s Hypothesis states that a single specific alteration in the sequence of nucleotides of an information-bearing DNA molecule results in a specific mutational effect. Within the framework of the DNA-protein coding problem developed elsewhere, and assuming the quasi-ergodicity of the general coding process, it is shown that Freese’s Hypothesis allows us to derive expressions for the length of the smallest mutable DNA molecule and to obtain a bound for the maximal number of allelic molecules of fixed length. To illustrate these ideas, calculations are carried out on appropriate data from bacternophage and man, and the results are shown to differ by a factor of 10 (modulo the rather crude approximations used). It is further shown that, if ρ(N) and ϱ(N) are respectively the number of information-bearing words of lengthN in a given code and the number of words of lengthN, then the number lim ρ(N)/ϱ(N) depends sensitively on the parameter ∈ which specifiesN→∞ the given code. The implications of this result for the spontaneous aggregation of a sufficient number of information-bearing words to characterize an organism are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476743
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  • 7
    Electronic Resource
    Electronic Resource
    On the role of chemical systems in the microphysical aspects of primary genetic mechanisms (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 393-403 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract It is pointed out that two fundamentally different views of primary genetic processes occur in the literature which are frequently confused. The first is a true communication-theoretic view, which regards the genetic apparatus as containing a real information-source and a transducer which converts that information to useful form. The second view is generally expressed as a template scheme based on the Watson-Crick model; it is shown that in this model there is actually no such thing as genetic information in a communication-theoretic sense. Both views are then discussed on the basis of microphysical principles developed in previous work of the author (Bull. Math. Biophysics,22, 227–255, 1960) in an attempt to find which approach is in closer accord with the biological facts. It is shown that, if the communication-theoretic view is correct, then the information-bearing object must act as a “catalyst,” but it is pointed out that the type of catalysis involved must be of a fundamentally different nature than that occurring in familiar enzyme-catalyzed reactions. On the basis of general considerations of irreversible changes in microphysical measuring systems, it is shown that any type of template must suffer a gradual and irreversible denaturation, which seems to make it unlikely that a template could play a primary role in fundamental genetic processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476494
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    Paper (German National Licenses)
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