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  • 1
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 19 (2004), S. 0 
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: Porcine xenografts for pediatric right ventricular outflow tractus (RVOT) reconstruction lack durability, homografts lack availability. The Contegra is a valve bearing bovine jugular vein. It is tear resistant, well pliable, and permits RVOT reconstruction without further foreign material. The 108 Contegras implanted in Bad Oeynhausen from May 1999 until January 2003 represent the largest single-center Contegra experience. The study gives the preliminary results from a controlled prospective multicenter trial aiming at FDA admission. Methods: The patients' diagnoses were truncus arteriosus (27%), double outlet right ventricle (14%), tetralogy of Fallot (48%), transposition of great arteries (6%), rare complex malformation (2%), and Ross procedure (1%). Fifty-eight were female. Age: 2 days to 20.1 years, mean: 4.3 ± 5.2, median: 1.8 years. Thirty-three had primary implantations, 38 previous repairs, 37 conduit exchange. Total follow-up time: 227.7 years, mean: 2.1. About 848 echos were evaluated. Results: Early mortality: 7.4% (8 patients); 1 late death. None was Contegra-related. Echocardiographic controls showed no relevant average valvular gradient development. Trace and mild-grade insufficiency is frequent, without tendency to increase. Average insufficiency is between trace and mild unless RV pressure remains under 100 mmHg. Average individual right/left ventricle length ratios did not increase over time. We saw no relevant conduit dilatation and no leaflet calcification. Pulmonary artery stenoses had mainly extrinsic reasons. At 4 years, freedom- from- event rates were: reoperation for Conduit inflow or valvular degeneration: 100%; reoperation for pulmonary artery branch stenoses (n = 10) 86%, explantation (n = 4): 92%. Survival: 91.7%. Conclusion: Contegra is worth being considered as an alternative to homografts.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 3471-3483 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Electrostatically stabilized aqueous dispersions of nm-sized free lipid A particles at low volume fractions (1.0×10−4≤&nullset;≤3.5×10−4) in the presence of 1.0–10.0 mM NaCl (25 °C) have been characterized by static and quasielastic light scattering (QELS) techniques, electron microscopy (SEM and TEM), conductivity measurements, and acid–base titrations. QELS and electron microscopy (ρ¯TEM=8.0±0.6%) yield similar values for the particle size and particle size distribution (ρ¯QELS=10.9±0.75 %), whereas conductivity and acid–base titrations estimate surface chemical parameters (dissociation constant, ionizable sites, and Stern capacitance). Effective particle charges were determined by fits of the integral equation calculations of the polydisperse static structure factor, S¯(Q), to the light scattering data. Using the particle properties as determined from these experiments, the polydisperse structure factor, S¯(Q), was calculated as a function of volume fraction, &nullset;, which was found to be consistent with a S¯(Q) dependence on the number particle density. It can be concluded that, at low volume fractions and low ionic strength, the light scattering data are well represented by a Poisson–Boltzmann model (PBC) of fluid-like ordering of free lipid A in aqueous solution. We find that the light scattering data of this dispersion are best described by a model where only a small fraction of the ionizable phosphate groups is dissociated at neutral pH. Finally, light scattering studies of lipid A dispersions of volume fractions of 3.9×10−4≤&nullset;≤4.9×10−4 indicate the presence of long-range order, resulting in distinct peaks which can be assigned either to a face-centered cubic (fcc) lattice (a=51.7 nm) or a body-centered cubic (bcc) lattice (a=41.5 nm), respectively. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 9 (2003), S. 0 
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  The political implications of haemophilia in the marriage of King Alfonso XIII of Spain and Princess Victoria Eugenie Battenberg of England have been reviewed in recent books on history. However, the fact that they had haemophilic sons also affected their personal relationship. In this article, we review the consequences haemophilia bore on their lives. We feel great compassion for families who suffer the illness, be it ordinary people or members of royalty; however, in this case, it can be said that when the disease affected a royal couple, the political consequences were great.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: No data are available on differences in complication rate and long-term functioning between polyurethane and silicone percutaneous endoscopic gastrostomy (PEG) catheters.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:We randomized patients who qualified for PEG placement to receive either a polyurethane or silicone PEG catheter. Patients were prospectively monitored for 28 days after placement for the occurrence of complications. Data on long-term PEG survival were obtained retrospectively from the Hospital and general practitioner’s medical records.〈section xml:id="abs1-3"〉〈title type="main"〉Results:One hundred and six patients were randomized (polyurethane 50, silicone 56). During the first four weeks of follow-up, major complications occurred twice with both polyurethane and silicone PEGs (relative risk 1.1, 95% confidence interval: 0.11–11). Overall complications occurred four times with polyurethane and 17 times with silicone PEGs (relative risk 3.8, 95% confidence interval: 1.37–10.5). Long-term follow-up was available in 96 patients. Seven polyurethane PEGs and 10 silicone PEGs were removed because of PEG malfunctioning, the remainder functioned well until death or the reinstitution of oral feeding. The median complication-free survival was 916 days for the polyurethane PEG and 354 days for the silicone PEG (Log rank test: P=0.24).〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:Polyurethane PEG catheters were associated with less short-term complications than silicone catheters, but major complications and long-term function were comparable.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 1367-1368 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: In the title compound, pentacyclo[11.8.1.13,11.07,23.015,20]tricosa-3,5,7,9,11(23),15,17,19-octaen-22-one, C23H20O, the bicyclo[5.4.1]dodecan-12-one moiety takes a rigid conformation in which the seven- and eight-membered rings take chair and boat–boat forms, respectively. The molecule has a non-crystallographic mirror symmetry perpendicular to the benzene and naphthalene planes.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 18 (1958), S. 191-202 
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary By means of the silvercarbonate-method (Jabonero) a closed syncytial network of vegetative plasma strains with nuclei can be demonstrated around the apocrine glands. This network originates from amyelinated nerves or plasma strains accompanying the blood vessels. A plasmatic connection with the secretory and myoepithelial cells can not be proved. The neurofibrils never leave the nervous plasma bands in order to innervate non-nervous elements. In general, the vegetative terminal network is more sparsely distributed around the apocrine glands than around the eccrine glands. On account of the morphology and the fact that the nervous bands never could be found entering the non-nervous elements of the apocrine glands, a humoral transmission of the nervous impulse can be postulated. Histochemical examinations for specific cholinesterase in the nervous terminal network reveal that in contrary to the eccrine sweat glands only relatively few plasma bands around the apocrine glands contain specific cholinesterase. On behalf of the findings the theory of cholinergic innervation of the apocrine glands seems unlikely compared the well-proved theory of adrenergic innervation.
    Abstract: Résumé Avec la technique d'argent carbonate deJabonero il est possible de montrer dans la sphère des glandes apocrines de l'homme un réseau nerveux syncytial protoplasmique muni de noyaux se formant des nerfs amyéliniques ou des rubans végétatifs efférents accompagnant les vaisseaux. Une connexion protoplasmique aux cellules sécrétoires ou myoépithéliales n'est pas à prouver, ainsi les neurofibrilles ne quittent pas les rubans nerveux pour innerver quelques éléments non-nerveux. En tout, le syncytium nerveux distal a une un peu plus vaste étendue autour des glandes apocrines qu'autour des glandes eccrines. Par raison de la morphologie et des relations de voisinage étroit aux glandes apocrines, on suppose une transmission, humorale de l'impulsion nerveuse. Pour prouver la cholinestérase spécifique du syncytium nerveux distal, des recherches histochimiques ont montrées que — au contraire aux glandes eccrines —, seulement quelques rubans nerveux syncytiales protoplasmiques autour des glandes apocrines contiennent de la cholinestérase spécifique. Par conséquent, la supposition d'une innervation cholinérgique outre de l'innervation adrénergique ne peut étre considérée comme un fait prouvé.
    Notes: Zusammenfassung 1. Mit der Silbercarbonatmethode nachJabonero läßt sich im Bereich der apokrinen Drüsen des Menschen ein geschlossenes syncytiales kernhaltiges Netz aus vegetativen Plasmasträngen nachweisen, das entweder aus marklosen Nerven oder den die Gefäße begleitenden Bändern hervorgeht. Eine plasmatische Verbindung mit den sekretorischen und den myoepithelialen Zellen läßt sich nicht nachweisen. Auch verlassen die Neurofibrillen niemals die nervösen Plasmazüge, um einzelne nicht nervöse Elemente zu innervieren. Insgesamt ist das vegetative Endnetz an den apokrinen Drüsen etwas weitmaschiger als an den ekkrinen Drüsen. 2. Auf Grund der Morphologie und der ausschiließlich nachbarschaftlichen Geziehungen zu den aprokrinen Drüsen wird auf eine humorale Übertragung des nervösen Impulses geschlossen. Histochemische Untersuchungen zum Nachweis der spezifischen Cholinesterase im nervösen Endnetz ergeben, daß im Gegensatz zu den ekkrinen Schweißdrüsen nur relativ wenige Plasmastränge um die apokrinen Drüsen spezifische Cholinesterase enthalten, womit die Annahme einer Beteiligung “cholinergischer” Fasern neben der “adrenergischen” Innervation nicht genügend gesichert erscheint. Es wird vielmehr angenommen, daß es sich dabei um die synptischen Verknüpfungsstellen zwischen postganglionären Nervenfasern und dem distalen nervösen Syncytium handelt, wobei offenbar Acetylcholin eine Rolle speilt.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 71 (1907), S. 313-314 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 106 (1957), S. 232-233 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 103 (1956), S. 129-134 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 104 (1956), S. 203-205 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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