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  • 2000-2004  (3)
  • 1955-1959
  • pregnancy rate  (2)
  • AS-PCR  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Molecular staging of colorectal cancer (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 155-159 
    Details
    ISSN: 1530-0358
    Keywords: Colorectal cancer ; Micrometastasis ; Staging ; K-ras ; Lymph nodes ; AS-PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE. Multiple attempts have been made to improve the clinical/pathologic staging system of Dukes to focus adjuvant therapy decisions. The purpose of this study was to determine whetherK-ras mutational status of regional nodes in patients with Dukes B2 colorectal cancer could be used to stage their disease more accurately. METHODS: Using formalin-fixed, paraffin-embedded archival material, tumor samples were screened forK-ras mutations using a mutation-specific polymerase chain reaction method, followed by gel electrophoresis in a 96-well array. Patients with Dukes B2 tumors that have mutations in codon 12 or 13 of theK-ras gene were identified. RESULTS: Mutational analysis of the lymph nodes from these patients revealed an 80 percent (16/20) incidence of the same mutations in regional lymph nodes. None of the four patients with mutation-free nodes developed recurrence compared with 37.5 percent (6/16) withK-ras positive lymph nodes. CONCLUSIONS: The data suggest that patients with Dukes B2 colorectal cancers that have mutations in codon 12 or 13 of theK-ras gene are at high risk for the development of nodal metastases. Mutational analysis of the lymph nodes identifies high-risk patients who should be considered for adjuvant chemotherapy. Therefore,K-ras mutational analysis should be considered for molecular staging of colorectal cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02236973
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Effect of Patient and Semen Characteristics on Live Birth Rates Following Intrauterine Insemination: A Retrospective Study (2000)
    Springer
    Journal of assisted reproduction and genetics 17 (2000), S. 245-252 
    Details
    ISSN: 1573-7330
    Keywords: infertility—male ; infertility—female ; insemination—martificial ; sperm motility ; pregnancy rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To identify characteristics of female patients andof semen that were associated with live birth followingintra-uterine insemination (IUI). Methods: Retrospective review of medical and laboratoryresults from 533 women who underwent IUI with partner'ssperm from 1993 through 1995. Results: Among 1728 cycles, 116 (6.7%) resulted in livedeliveries. Among the 38 patient and semen variablesanalyzed, only 3 were associated with successful IUI outcome:female age 〈37.7 years at the time of treatment (P = 0.02);the absence of any corrective pelvic surgery (P 〈 0.001);and postwash sperm motility (P = 0.006). Couples withnone of these three risk factors achieved per-cycle pregnancyrates of 12.4%. Women with two risk factors (age and pelvicsurgery) achieved per-cycle pregnancy rates of 4.6% whensperm had good postwash motility. No pregnancies wereachieved when low postwash motility was combined withany other risk factor. Conclusions: Advanced female age, poor postwash spermmotility, and a history of corrective pelvic surgery aresignificant risk factors for poor IUI success rates. Poor postwashsperm motility in combination with either of these other tworisk factors resulted in no successful pregnancies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009402214820
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of Clinical and Semen Characteristics on Efficacy of Ovulatory Stimulation in Patients Undergoing Intrauterine Insemination (2000)
    Springer
    Journal of assisted reproduction and genetics 17 (2000), S. 189-193 
    Details
    ISSN: 1573-7330
    Keywords: infertility-female ; ovulation induction ; pregnancy rate ; insemination-artificial ; sperm motility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: We measured the effect of ovulatory stimulation(OS) upon intrauterine insemination (IUI) success rates,particularly among patients with risk factors for IUI failure. Methods: Retrospective review of medical and laboratoryresults from 512 patients who underwent 1576 cycles ofIUI with partner's sperm over a 3 year period. Data werecollected on 3 risk factors for IUI failure (advanced femaleage 〉37.7 years, prior corrective pelvic surgery, and poorpost-wash sperm motility), and on method of OS (none,clomiphene citrate, or gonadotropin). Results: Patients who underwent OS had significantly higherpregnancy rates (7.6;pc) than those who did not (4.7%, p =0.02). However, when patients were stratified by their riskfactors, OS made a significant difference only for patientswithout risk factors. These patients had a 15.5% per cyclepregnancy rate with OS, compared to 7.9% in unstimulatedIUI cycles (p = 0.04). Conclusions: Ovulatory stimulation doubles IUI pregnancyrates among young patients without a prior pelvic surgeryand with good post-wash semen quality. The benefit of OSfor patients with risk factors for IUI failure is unclear. Thesepatients should be counseled that their chances for successwith IUI are limited, with or without OS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009426415419
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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