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  • 1
    Electronic Resource
    Electronic Resource
    Lobenzarit disodium-induced hyperkalemia successfully treated with fludrocortisone acetate (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 67-70 
    Details
    ISSN: 1437-7799
    Keywords: Key words Lobenzarit disodium ; Hyperkalemia ; Tubulointerstitial nephritis ; Fludrocortisone acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 65-year-old woman was admitted to our hospital because of hyperkalemia and renal dysfunction. Three months after she had been treated with lobenzarit disodium, a disease-modifying anti-rheumatic drug, her serum potassium and blood urea nitrogen levels rose. Neither calcium polystyrene sulfonate nor furosemide was effective in treating the hyperkalemia. On admission, she did not show metabolic acidosis and her creatinine clearance was 41 ml/min. Urinalysis results and urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase concentrations were normal. Her pituitary and adrenal functions and renin-aldosterone axis were also normal. A renal biopsy specimen demonstrated almost normal glomeruli and almost normal proximal tubules. On the other hand, the distal tubules demonstrated patchy atrophy with an increase in the interstitium and an infiltration of mononuclear cells. Fludrocortisone acetate, a synthetic mineralocorticoid, was effective in treating her hyperkalemia. The impaired responsiveness of the distal nephron to mineralocorticoid may have been the pathophysiological mechanism in this patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050065
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  • 2
    Electronic Resource
    Electronic Resource
    Nicorandil increases adenosine 5′-monophosphate-primed interstitial adenosine via activation of ecto-5′-nucleotidase in rat hearts (2000)
    Springer
    Heart and vessels 15 (2000), S. 81-85 
    Details
    ISSN: 1615-2573
    Keywords: Key words Nicorandil ; Adenosine ; Ecto-5′-nucleotidase ; Cyclic guanosine monophosphate ; Microdialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With the use of microdialysis techniques, we examined the effects of nicorandil, a hybrid of an ATP-sensitive K+ (KATP) channel opener and a nitrate compound, on the production of interstitial adenosine in rat hearts in situ. The level of dialysate adenosine measured under a constant supply of adenosine 5′-monophosphate (AMP) reflected the activity of endogenous ecto-5′-nucleotidase. Nicorandil (0.3–3 mM) increased the level of AMP (100 μM)-primed dialysate adenosine in a concentration-dependent manner, and this effect was completely abolished by the guanylate cyclase inhibitor, methylene blue (100 μM), but not by the KATP channel blocker, glibenclamide (10 μM). Another KATP channel opener, cromakalim (0.1–1 mM), did not increase the production of AMP-primed dialysate adenosine. These results suggest that nicorandil increases the level of interstitial adenosine via cyclic guanosine monophosphate-mediated activation of ecto-5′-nucleotidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003800070036
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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