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FORM AND CONTENT IN The Scarlet Letter. (1944)

Gerber, J. C.

Brunswick, Me., etc. : Periodicals Archive Online (PAO)

New England Quarterly. 17:1/4 (1944) 25

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ISSN: 0028-4866

Thema: Anglistik, Amerikanistik

URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1170-1944-001-00-000002

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Digitale Medien

Origin of the paired domain (2000)

Breitling, Rainer ; Gerber, J.-K.

Springer

Development genes and evolution 210 (2000), S. 644-650

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ISSN: 1432-041X

Schlagwort(e): Keywords Pax protein ; Paired domain ; Homeobox ; Transposase ; Evolution

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract Pax proteins play a diverse role in early animal development and contain the characteristic paired domain, consisting of two conserved helix-turn-helix motifs. In many Pax proteins the paired domain is fused to a second DNA binding domain of the paired-like homeobox family. By amino acid sequence alignments, secondary structure prediction, 3D-structure comparison, and phylogenetic reconstruction, we analyzed the relationship between Pax proteins and members of the Tc1 family of transposases, which possibly share a common ancestor with Pax proteins. We suggest that the DNA binding domain of an ancestral transposase (proto-Pax transposase) was fused to a homeodomain shortly after the emergence of metazoans about one billion years ago. Using the transposase sequences as an outgroup we reexamined the early evolution of the Pax proteins. Our novel evolutionary scenario features a single homeobox capturing event and an early duplication of Pax genes before the divergence of porifera, indicating a more diverse role of Pax proteins in primitive animals than previously expected.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004270000106

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