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  • 2000-2004  (10)
  • 1930-1934  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The stress-activated kinases c-Jun N-terminal kinase (JNK)and p38 are members of the mitogen-activated protein (MAP) kinase family andtake part in signalling cascades initiated by various forms of stress. Theirtargets include the microtubule-associated protein tau, which becomeshyperphosphorylated in Alzheimer's disease. It is necessary, as a forerunnerfor in vivo studies, to identify the protein kinases and phosphatases that areresponsible for phosphate turnover at individual sites. Using nanoelectrospraymass spectrometry, we have undertaken an extensive comparison ofphosphorylation in vitro by several candidate tau kinases, namely, JNK, p38,ERK2, and glycogen synthase kinase 3β (GSK3β). Between 10 and 15sites were identified for each kinase. The three MAP kinases phosphorylatedSer202 and Thr205 but not detectably Ser199,whereas conversely GSK3β phosphorylated Ser199 but notdetectably Ser202 or Thr205. PhosphorylatedSer404 was found with all of these kinases except JNK. The MAPkinases may not be strictly proline specific: p38 phosphorylated thenonproline sites Ser185, Thr245, Ser305, andSer356, whereas ERK2 was the most strict. All of the sites detectedexcept Thr245 and Ser305 are known or suspected phosphorylation sites in paired helical filament-tau extracted from Alzheimer brains. Thus, the three MAP kinases and GSK3β are importantly all strong candidates as tau kinases that may be involved in the pathogenic hyperphosphorylation of tau in Alzheimer's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0741587.x
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  • 2
    Electronic Resource
    Electronic Resource
    Freezing Points and Triple Points with Water (1934)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 56 (1934), S. 20-24 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01316a006
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Extra Specific Heat in Cuprous Sulfide; Specific Heat of Ferrous Oxide (1933)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 55 (1933), S. 1047-1053 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01330a026
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    What Are Assets and Liabilities? Where Is True North? (Accounting That my Sister Would Understand) (2001)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Abacus 37 (2001), S. 0 
    Details
    ISSN: 1467-6281
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: This is an article about what I think financial accounting and reporting ought to look like—about my vision that the singular focus of financial accounting and reporting should be on cash, that is, cash itself, contractual claims to cash, things (assets) that can be converted into cash, and obligations to pay cash, and that assets and liabilities should be stated at fair value in corporate balance sheets. I call this formulationTrue North.I previously have written about how we should keep financial accounting and reporting simple (‘Keep It Simple’, Accounting Horizons, June 1991, pp. 113–17). I also have written about how assets should be defined for accounting purposes (‘What Is an Asset?’, Accounting Horizons, Septem-ber 1993, pp. 66–70). This article builds on those two earlier ones. It deals with definitions of assets and liabilities that should be recognized (that is, displayed, shown, or reported) in corporate balance sheets and how the recognized assets and liabilities should be measured when reported in those balance sheets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-6281.00072
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of solar radiation and the subsequent dark periods on two newly isolated and characterized Antarctic marine bacteria (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Polar research 23 (2004), S. 0 
    Details
    ISSN: 1751-8369
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Geosciences
    Notes: Two strains of psychrotolerant Antarctic marine bacteria were isolated and characterized using biochemical and molecular techniques. Sequencing of 16S rRNA gene showed that UVvi strain belongs to the genus Arthrobacter whereas UVps strain is related to the Flexibacter-Cytophaga-Bacteroides (FCB) group. Response of the strains to solar radiation was studied during the summer of 1999 in Potter Cove, near Jubany station (South Shetland Island, Antarctica). The effect of photosynthetically available radiation (PAR, 400-700 nm), ultraviolet-A (UV-A, 320-400 nm) and ultraviolet-B radiation (UV-B, 280-320 nm) on cell viability was studied using mixed cultures in quartz bottles covered with interferential filters and exposed to solar radiation. In all experiments, four treatments were used: dark (with light screened out), PAR (with UV radiation screened out), PAR+UV-A (UV-B screened out) and PAR+UV-A+UV-B. Under the assayed conditions, PAR+UV-A and PAR+UV-A+UV-B radiation showed similar negative effects on the viability of the studied strains. However, at the end of the exposure time, mortality values in PAR+UV-A+UV-B treatments were higher than those observed under PAR+UV-A treatments. In both PAR+UV-A and PAR+UV-A+UV-B treatments we observed high levels of hydrogen peroxide compared with the dark control. The Arthrobacter UVvi strain showed significant recovery in dark conditions after exposure to the PAR+UV-A but not after the PAR+UV-A+UV-B treatment. This strain proved to be more resistant to UV radiation than the FCB group-related UVps strain. The results showed that UV radiation has a deleterious effect on these Antarctic marine bacteria and also revealed that the analysed components of the Antarctic bacterioplankton may have different responses when they are exposed to the same irradiance conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1751-8369.2004.tb00130.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of isolation temperature on the characteristics of extracellular proteases produced by Antarctic bacteria (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Polar research 21 (2002), S. 0 
    Details
    ISSN: 1751-8369
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Geosciences
    Notes: Protease-producing psychrotolerant bacteria were isolated from Antarctic biotopes on casein agar plates using different incubation temperatures. Most of the isolates were non-spore-forming Gram-negative motile rods with catalase activity, 30% were pigmented and none of them were glucose fermenters. All the strains were grown in liquid cultures at 20°C and protease secretion was tested using the azocasein method. Despite their capacity for production of a clear zone of hydrolysis in agar plates, some strains did not produce detectable levels of proteolytic activity in liquid cultures. The lowest apparent optimum temperature for protease activity found in culture supernatants was 40°C. Almost all the strains showed activation energy values about 10-20 kJ-mol−1 lower than that observed for a mesophilic Subtilisin. Most of the proteases showed optimal activity at neutral or alkaline pH values and developed a multiple-band profile on gelatine-SDS-PAGE. It was observed that the lower the strain isolation temperature was, the more stongly cold-adapted–in terms of optimal temperature and activation energy–were the proteases produced by them. This dependence of the characteristics of the proteases on the isolation temperature is an important factor to take into account in the design of screening programmes directed towards the isolation of psychrotolerant bacteria able to produce proteases strongly or weakly adapted to work in the cold. The Antarctic area explored proved to be a promising source of proteolytic bacteria with potential use in industrial processes to be carried out at low or moderate temperatures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1751-8369.2002.tb00067.x
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  • 7
    Electronic Resource
    Electronic Resource
    Mandibular pseudocarcinomatous hyperplasia (2000)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 37 (2000), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims: Three unusual cases of pseudocarcinomatous (pseudoepitheliomatous) hyperplasia (PH) affecting chronic osteomyelitic mandibular sequestra are reported to highlight the differences with the various squamous neoplasms which occur in that site. Methods and results: In two patients carrying a mandibular graft following the excision of an ameloblastoma, mucosal ulcers resulted in chronic osteomyelitis. In a third patient, an apical dental infection was associated with fistulated osteomyelitis. Histology of the three sequestra showed an intraosseous squamous proliferation. It was characterized by a peripheral involvement of medullary spaces, the more mature epithelial layer covering the bone trabeculae without intervening stroma, and the basal type epithelial layer surrounding a central fibrovascular core. There were no histological or cytological signs of malignancy. Conclusions: PH shows an inverted pattern when compared with the centro-medullary tumoural islands seen in the various oral or odontogenic squamous neoplasms which occur in the jaws. The lack of signs of malignancy distinguish PH from common squamous cell carcinomas. A short clinical course is an important feature in the distinction of PH from the well differentiated squamous cell carcinomas which may develop in fistulated chronic osteomyelitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2000.00949.x
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  • 8
    Electronic Resource
    Electronic Resource
    An efficient method for solving RNA structures: MAD phasing by replacing magnesium with zinc (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 330-332 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The structure of a 46-nucleotide RNA complex has been successfully solved using multi-wavelength anomalous dispersion (MAD) at the zinc K edge. Taking advantage of the eight magnesium-binding sites, it has been shown that for five of them magnesium could be replaced by zinc. This resulted in an excellent 2.0 Å MAD electron-density map. Zinc, in common with some other transition metals, is able to replace magnesium in RNA structures, but zinc has the advantage of its K edge being ideally located at 1.284 Å. As most RNA molecules contain magnesium-binding sites, it is suggested that this method could be a valuable alternative to the use of bromo derivatives of bases, which is limited to chemically synthesizable and thus rather short RNA sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444900017558
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  • 9
    Electronic Resource
    Electronic Resource
    Das Syndrom des Lig. arcuatum medianum mit Zweigefäßbeteiligung (2000)
    Springer
    Gefässchirurgie 5 (2000), S. 214-214 
    Details
    ISSN: 1434-3932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010596
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  • 10
    Electronic Resource
    Electronic Resource
    Selection of side-chain carbons in a high-molecular-weight, hydrophobic peptide using solid-state spectral editing methods (2000)
    Springer
    Journal of biomolecular NMR 18 (2000), S. 139-144 
    Details
    ISSN: 1573-5001
    Keywords: CPMAS ; elastin ; solid-state NMR ; spectral editing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Solid-state spectral editing techniques have been used by others to simplify 13C CPMAS spectra of small organic molecules, synthetic organic polymers, and coals. One approach utilizes experiments such as cross-polarization-with-polarization-inversion and cross-polarization-with-depolarization to generate subspectra. This work shows that this particular methodology is also applicable to natural-abundance 13C CPMAS NMR studies of high-molecular-weight biopolymers. The editing experiments are demonstrated first with model peptides and then with α-elastin, a high-molecular-weight peptidyl preparation obtained from the elastic fibers in mammalian tissue. The latter has a predominance of small, nonpolar residues, which is evident in the crowded aliphatic region of typical 13C CPMAS spectra. Spectral editing is particularly useful for simplifying the aliphatic region of the NMR spectrum of this elastin preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008334931234
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