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  • 2000-2004  (2)
  • 1900-1904
  • (H2O)2HCl  (1)
  • 5-aminosalicylic acid  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Nature and importance of three-body interactions in the (H2O)2HCl trimer (2000)
    Springer
    Theoretical chemistry accounts 104 (2000), S. 195-198 
    Details
    ISSN: 1432-2234
    Keywords: Key words: Symmetry-adapted perturbation theory ; Three-body interactions ; Ab initio calculations ; (H2O)2HCl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract.  The nature and importance of nonadditive three-body interactions in the (H2O)2HCl cluster have been studied by the supermolecule coupled-cluster method and by symmetry-adapted perturbation theory (SAPT). The convergence of the SAPT expansion was tested by comparison with the results obtained from the supermolecule coupled-cluster calculations including single, double, and noniterative triple excitations [CCSD(T)]. It is shown that the SAPT results reproduce the converged CCSD(T) results within 3% at worst. The SAPT method has been used to analyze the three-body interactions for various geometries of the (H2O)2HCl cluster. It is shown that the induction nonadditivity is dominant, but it is partly quenched by the first-order Heitler–London-type exchange and higher-order exchange–induction/deformation terms. This implies that the classical induction term alone is not a reliable approximation to the nonadditive energy and that it will be difficult to approximate the three-body potential for (H2O)2HCl by a simple analytical expression. The three-body energy represents as much as 21–27% of the pair CCSD(T) intermolecular energy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002140000136
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    5-Aminosalicylic Acid and Olsalazine Inhibit Tumor Growth in a Rodent Model of Colorectal Cancer (2000)
    Springer
    Digestive diseases and sciences 45 (2000), S. 1578-1584 
    Details
    ISSN: 1573-2568
    Keywords: chemoprevention ; colorectal cancer ; 5-aminosalicylic acid ; olsalazine ; apoptosis ; bromdeoxyuridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of 5-aminosalicylic acid and olsalazine to inhibit colonic aberrant crypts and tumors was investigated in 1,2-dimethylhydrazine-treated rats. The effect of these drugs on the rates of tumor apoptosis and proliferation was studied as potential mechanisms for their action. 5-Aminosalicylic acid reduced the number of aberrant crypt foci by over one third, while olsalazine had no effect on this parameter. However, both agents effectively reduced tumor number and load, increased the rate of tumor apoptosis, and reduced the rate of tumor cell proliferation. In conclusion, 5-aminosalicylic acid and olsalazine are both ultimately effective chemopreventive agents in this model; however, only 5-aminosalicylic acid inhibited the formation of aberrant crypt foci. The inhibitory effect of these agents in tumors is related to the inhibition of proliferation and the induction of apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005517112039
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    Paper (German National Licenses)
    Fulltext
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