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  • 2000-2004  (5)
  • 1880-1889
  • Key words Denitrification  (2)
  • chemotherapy  (2)
  • Aging  (1)
  • 1
    ISSN: 1569-8041
    Schlagwort(e): antifolate ; chemotherapy ; pancreatic cancer ; thymidylate synthase inhibitor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose:To determine the safety and activity of LY231514(ALIMTA™, MTA, pemetrexed disodium, Eli Lilly and Co.,Indianapolis, IN) in chemotherapy-naïve patients with advanced pancreaticcancer. Patients and methods:Patients with unresectable or metastaticpancreatic cancer received LY231514 600 mg/m2 as a 10–minuteinfusion every three weeks. Results:Forty-two patients were enrolled in this phase II trial.The median age was 60.3 (range 37–77) years; 79% had metastaticdisease. Neutropenia was common (40% of patients ≥ grade 3) butinfectious complications were rare. Significant anemia or thrombocytopeniaoccurred in 〈20% of patients. Non-hematologic toxicities includedgrade 2 or 3 skin reaction which was ameliorated by dexamethasone. Elevationsof bilirubin or transaminases were infrequent (〈25% of patients) anddid not require dose reductions or treatment delays. Thirty-five patientsreceived two cycles of therapy and were evaluable for response. One complete(duration 16.2 months) and one partial (duration 6.9 months) were observedresulting in an objective response rate of 5.7% for evaluable patients.In addition, 17 patients (40%) had stable disease that lasted ≥6months in 5 patients. The median survival was 6.5 months, with 28% ofpatients alive at one year. Conclusions:LY231514 is a well-tolerated agent with minimalobjective antitumor activity in pancreatic cancer. The median and one yearsurvival times, which may be important indicators in phase II trials of newagents, are of interest. Combination trials of LY231514 in pancreatic cancerare planned.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-0789
    Schlagwort(e): Key words Denitrification ; N mineralization ; Semiarid subtropical soils ; Flooded rice systems ; Nearly saturated rice systems
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract  The influence of fertilizer N applied through nitrate and ammoniacal sources on the availability of nitrate, supply of C, and gaseous N losses via denitrification (using acetylene inhibition technique) in a semiarid subtropical soil (Typic Ustochrepts) was investigated in a growth chamber simulating upland [60% water-filled pore space (WFPS)], nearly saturated (90% WFPS), and flooded (120% WFPS) conditions. The rate of denitrification was very low in the upland soil conditions, irrespective of fertilizer N treatments. Increasing water content to nearly saturated and flooded conditions resulted in four- to sixfold higher rates of denitrification within 2 days, suggesting that the denitrifying activity commences quickly. Results of this study reveal that (1) under restricted aeration, these soils could support high rates of denitrification (∼6 mg N kg–1 day–1) for short periods when nitrate is present; (2) application of fertilizer N as nitrate enhances N losses via denitrification (∼10 mg N kg–1 day–1) – however, the supply of available C determines the intensity and duration of denitrification; (3) when fertilizer N is applied as an ammoniacal form, nitrification proceeds slowly and nitrate availability limits denitrification in flooded soil; (4) the nearly saturated soil, being partially aerobic, supported greater nitrification of applied ammoniacal fertilizer N than flooded soil resulting in higher relative rates of denitrification; and (5) under aerobic soil conditions, 26 mg mineral N kg–1 accumulated in control soil over a 16-day period, demonstrating a modest capacity of such semiarid subtropical soils, low in organic matter, to supply N to growing plants.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-0789
    Schlagwort(e): Key words Denitrification ; N mineralization ; Semiarid subtropical soils ; Flooded rice systems ; Water regime
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract  Nitrogen and carbon mineralization of cattle manure (N=6 g kg–1; C:N=35), pressmud (N=17.4 g kg–1; C:N=22), green manure (N=26.8 g kg–1; C:N=14) and poultry manure (N=19.5 g kg–1; C:N=12) and their influence on gaseous N losses via denitrification (using the acetylene inhibition technique) in a semiarid subtropical soil (Typic Ustochrepts) were investigated in a growth chamber simulating upland, nearly saturated, and flooded conditions. Mineralization of N started quickly in all manures, except pressmud where immobilization of soil mineral N was observed for an initial 4 days. Accumulation of mineral N in upland soil plus denitrified N revealed that mineralization of cattle manure-, pressmud-, poultry manure- and green manure-N over 16 days was 12, 20, 29 and 44%, respectively, and was inversely related to C:N ratio (R 2=0.703, P=0.05) and directly to N content of organic manure (R 2=0.964, P=0.01). Manure-C mineralized over 16 days ranged from 6% to 50% in different manures added to soil under different moisture regimes and was, in general, inversely related to initial C:N ratio of manure (R 2=0.690, P=0.05). Cumulative denitrification losses over 16 days in control soils (without manure) under upland, nearly saturated, and flooded conditions were 5, 23, and 24 mg N kg–1, respectively. Incorporation of manures enhanced denitrification losses by 60-82% in upland, 52–163% in nearly saturated, and 26–107% in flooded soil conditions over a 16-day period, demonstrating that mineralized N and C from added manures could result in 2- to 3-fold higher rate of denitrification. Cumulative denitrification losses were maximal with green manure, followed by poultry manure, pressmud and cattle manure showing an increase in denitrification with increasing N content and decreasing C:N ratio of manure. Manure-amended nearly saturated soils supported 14–35% greater denitrification than flooded soils due to greater mineralization and supply of C.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cross-cultural gerontology 15 (2000), S. 81-97 
    ISSN: 1573-0719
    Schlagwort(e): Aging ; Age grades ; Japan ; Religion ; Ritual ; Symbolic capital
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Ethnologie , Sociologie
    Notizen: Abstract Most research by gerontologists into the relationshipbetween religion and aging has focused upon thepotential health benefits of religious participationamong Americans who follow Judeo-Christian orientedforms of worship and belief. This research has shownthat both as a social institution and source ofexistential meaning, religion provides an importantresource for older people in terms of fellowship andas a means of coping and adapting to social change andpersonal loss. Other religious traditions and otheraspects of salience of religious participation forolder people have been less thoroughly considered. This article investigates a religious ritual in Japan,that, rather than being a source of consolation, is anexpression of symbolic capital associated with elderstatus and, thus, gerontocratic power. The ritualcontributes to representing and reproducing the powerof older residents in a rural Japanese community,partly due to its being administratively situatedwithin an age-grade system that is a part ofneighborhood political organization. Through itsperformance, the ritual visually reproduces andrepresents stratified social structures thatconcentrate power in the hands of male members of thesenior age grade.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    ISSN: 1573-0646
    Schlagwort(e): Malignant melanoma ; prostate cancer ; chemotherapy ; clinical trial
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Introduction: CI-980 is a novel chemotherapeutic agent thatinhibits polymerization of tubulin. Preclinical studies haveindicated a high level activity of this agent against various tumorcell lines. Methods: 13 malignant melanoma patients who hadfailed prior chemotherapy and/or immunotherapy and 13 hormonerefractory prostate cancer patients, including 4 who had receivedprior chemotherapy, were treated in 2 separate NCI-supportedclinical trials. Subjects received a recommended phase II dose ofCI-980 of 4.5 mg/m2/day by continuous infusion for 72 hoursevery 3 weeks. Results: No activity was seen in either study.Toxicity was tolerable with neutropenia being the most common,significant toxicity. Among the melanoma patients, 15% and 31%developed grade 3 and grade 4 neutropenia, while 7% and 38% ofthe prostate patients developed grade 3 and grade 4 neutropenia,respectively. Conclusions: CI-980 at this dose and scheduleis ineffective against malignant melanoma and hormone refractoryprostate cancer.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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