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  • 2000-2004  (3)
  • Articular cartilage biomechanics  (1)
  • HNF-4γ  (1)
  • PACS. 03.65.Ud Entanglement and quantum nonlocality (e.g. EPR paradox, Bell's inequalities, GHZ states, etc.) – 03.67.Lx Quantum computation – 75.10.Jm Quantized spin models  (1)
  • 1
    Electronic Resource
    Electronic Resource
    No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4γ gene (HNF4G) in Japanese patients with MODY (2000)
    Springer
    Diabetologia 43 (2000), S. 1064-1069 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Maturity-onset diabetes of the young ; MODY ; transcription factor ; nuclear receptor ; HNF-4γ ; diabetes mellitus ; insulin ; genetics ; mutation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mutations in the transcription factor hepatocyte nuclear factor (HNF)-4α are the cause of one form of maturity-onset diabetes of the young, MODY1. The HNF-4γ is structurally related to HNF-4α and is expressed together with HNF-4α in pancreatic islets. We therefore tested the hypothesis that genetic variation in the HNF-4γ gene (HNF4G) is associated with MODY in Japanese subjects. Methods. We screened the protein coding region of HNF4G (exons 3–11) for mutations in 57 unrelated Japanese subjects with MODY by amplifying each exon and adjacent intron region using the polymerase chain reaction (PCR) and specific primers and then directly sequencing the PCR products. The frequency of each variant was compared between patients with MODY and a group of non-diabetic subjects. Results. We found ten sequence variants, two of these were located in exons: exon 6, a silent substitution in codon 144, c.432A/G and exon 7, a G-to-A substitution in codon 190 (c.570G/A) resulting in a conservative Met-to-Ile substitution (M/I190) in the putative ligand-binding region of HNF-4γ protein. The remaining eight variants were located in introns. There was no significant difference in the frequency of these polymorphisms between subjects with MODY and non-diabetic control subjects. Conclusion/interpretation. Genetic variation in the coding region of HNF4G is unlikely to be a major cause of MODY in Japanese people. [Diabetologia (2000) 43: 1064–1069]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051491
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Aging And Dietary Restriction On The Structural Integrity of Rat Articular Cartilage (2000)
    Springer
    Annals of biomedical engineering 28 (2000), S. 143-149 
    Details
    ISSN: 1573-9686
    Keywords: Articular cartilage biomechanics ; Rat cartilage ; Diet ; Aging ; Creep indentation ; Mechanical properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The objectives of this study were to investigate the effects of aging and diet restriction on the biomechanical properties of articular cartilage, using a well-controlled rat model (Fischer 344). This animal model is recommended by the National Institute of Aging specifically to study aging and diet issues. The intrinsic biomechanical properties of articular cartilage were obtained using a creep indentation approach. The ages chosen (6, 12, 18, 24 months of age) correspond to approximate human ages of 20 to 80 years old. The diet regimen employed in this study used either an ad libitum fed group or a group fed 60% of the mean food intake of the ad libitum group. The results demonstrate that, unlike bone, rat articular cartilage biomechanical properties are not affected in a discernible manner by diet restriction, despite the fact that diet-restricted animals were significantly lighter in terms of body weight. Age effects on biomechanical properties are found only at 6 and 12 months probably due to developmental reasons, but not at later ages. It appears that aging and diet restriction have profoundly different effects on articular cartilage and bone. Another significant result of this study was to establish the rat as a suitable animal model to study cartilage biomechanical properties. Thus, the rat can be added to the list of animals that can be used to study structure-function and pathophysiological relationships in articular cartilage. © 2000 Biomedical Engineering Society. PAC00: 8714Ee, 8715La, 8719Rr
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1114/1.238
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  • 3
    Electronic Resource
    Electronic Resource
    Pairwise entanglement in symmetric multi-qubit systems (2002)
    Springer
    The European physical journal 18 (2002), S. 385-391 
    Details
    ISSN: 1434-6079
    Keywords: PACS. 03.65.Ud Entanglement and quantum nonlocality (e.g. EPR paradox, Bell's inequalities, GHZ states, etc.) – 03.67.Lx Quantum computation – 75.10.Jm Quantized spin models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: For pairs of particles extracted from a symmetric state of N two-level systems, the two-particle density matrix is expressed in terms of expectation values of collective spin operators for the large system. Results are presented for experimentally relevant examples of pure states: Dicke states | S, M〉, spin coherent, and spin squeezed states, where only the symmetric subspace, S = N/2 is populated, and for thermally entangled mixed states populating also lower S values. The entanglement of the extracted pair is then quantified by a calculation of the concurrence, which provides directly the entanglement of formation of the pair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjd/e20020045
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    Paper (German National Licenses)
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