Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1530-0358
    Keywords: Microscopic peritoneal dissemination ; Colon-cancer ; Gastric cancer ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: We evaluated the incidence and prognostic relevance of microscopic intraperitoneal tumor cell dissemination of colon cancer in comparison with dissemination of gastric cancer as a rational for additive intraperitoneal therapy. METHODS: Peritoneal washouts of 90 patients with colon and 111 patients with gastric cancer were investigated prospectively. Sixty patients with benign diseases and 8 patients with histologically proven gross visible peritoneal carcinomatosis served as controls. Intraoperatively, 100 ml of warm NaCl 0.9 percent were instilled and 20 ml were reaspirated. In all patients hematoxylin and eosin staining (conventional cytology) was performed. Additionally, in 36 patients with colon cancer and 47 patients with gastric cancer, immunostaining with the HEA-125 antibody (immunocytology) was prepared. The results of cytology were assessed for an association with TNM category and cancer grade, based on all patients, and with patient survival, among the R0 resected patients. RESULTS: In conventional cytology 35.5 percent (32/90) of patients with colon cancer and 42.3 percent (47/111) of patients with gastric cancer had a positive cytology. In immunocytology 47.2 percent (17/36) of patients with colon cancer and 46.8 percent (22/47) of patients with gastric cancer were positive. In colon cancer, positive conventional cytology was associated with pT and M category (P=0.044 andP=0.0002), whereas immunocytology was only associated with M category (P=0.007). No association was found between nodal status and immunocytology in colon cancer and with the grading. There was a statistically significant correlation between pT M category and conventional and immunocytology in gastric cancer (P〈0.0015/P=0.007 andP〈0.001/P=0.009, respectively). Positive immunocytology was additionally associated with pN category (P=0.05). In a univariate analysis of R0 resected patients (no residual tumor), positive immunocytology was significantly related to an unfavorable prognosis in patients with gastric cancer only (n=30). Mean survival time was significantly increased in patients with gastric cancer with negative cytology compared with positive cytology (1,205 (standard error of the mean, 91)vs. 771 (standard error of the mean, 147) days;P=0.007) but not in patients with colon cancer (1,215 (standard error of the mean, 95)vs. 1,346 (standard error of the mean, 106) days;P=0.55). CONCLUSIONS: Because microscopic peritoneal dissemination influences survival time after R0 resections only in patients with gastric but not with colon cancer, our results may provide a basis for a decision on additive, prophylactic (intraperitoneal) therapy in gastric but not colon cancer.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1433-0423
    Keywords: Schlüsselwörter Glaukom ; Katarakt ; Kombinierte Operation ; Phakoemulsifikation ; Keywords Glaucoma ; Cataract ; Combined operation ; Phacoemulsification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background. Glaucoma patients who need filtering surgery very often have cataracts as well. Combined glaucoma/cataract surgery entails a higher rate of complications and may endanger the results of glaucoma surgery. Patients and methods. This retrospective study investigated 223 eyes in 169 patients with uncontrolled glaucoma and cataracts. Each eye received filtering surgery and simultaneous phacoemulsification with implantation of a foldable posterior chamber lens. Mean follow-up was 32.5 months (6–57). Results. Mean intraocular pressure was lowered from 24.6±6.2 to 16.4±3.4 mmHg (P〈0.0001). Visual acuity improved from 0.25 (0.01–0.5) to 0.5 (0.01–1.0). Preoperatively the mean number of medications was 2.4 (1–6) and postoperatively 1.3 (1 or 2). The most common perioperative complications were choroidal detachment (20.2%) and fibrin reaction in 10.1%; those occurring later than 4 weeks postoperatively were posterior capsule opacification requiring YAG laser capsulotomy (11.5%) and scarring of filtering bleb (7.7%). Conclusion. Complications encountered in the combined procedure were due mainly due to cataract surgery of glaucomatous eyes with narrow pupils and posterior synechiae. A shallow anterior chamber occurred in only one case. Despite complications the success rate in lowering intraocular pressure was comparable to that observed in filtering surgery alone.
    Notes: Zusammenfassung Hintergrund.Ältere Patienten mit Glaukom weisen häufig auch eine Katarakt auf, weshalb sich die Kombination der Glaukomoperation mit Phakoemulsifikation und faltbarer Hinterkammerlinsenimplantation anbietet. Patienten und Methode. Retrospektiv wurden 223 Augen von 169 Patienten mit einem Glaukom und simultaner Katarakt kombiniert operiert. Die gedeckte Goniotrepanation bzw. Trabekulektomie erfolgte im Bereich des Tunnels der Phakoemulsifikation. Ergebnisse. Die Nachbeobachtungszeit beträgt im Mittel 32,5 Monate. Der mittlere intraokulare Druck unter Medikation konnte von 24,6 mmHg auf 16,4 mmHg gesenkt werden (p〈0,0001). Durch die simultane Kataraktoperation kam es zu einem Visusanstieg von 0,25 auf 0,5 (p〈0,0001). Präoperativ waren im Mittel 2,4 Glaukommedikamente, postoperativ 1,3 erforderlich. Die häufigsten perioperativen Komplikationen sind Amotio chorioidae (20,2%) und Fibrinreaktion (10,1%); die häufigsten langfristigen postoperativen Komplikationen waren Nachstar mit YAG-Kapsulotomie (11,5%) und Sickerkissenvernarbung (7,7%). Schlussfolgerung. Die postoperativen Komplikationen ergeben sich aus der Kombination der beiden Operationsmethoden. Die intraokulare Drucksenkung ist trotz dieser Komplikationen hochsignifikant (p〈0,0001).
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...