ISSN:
1432-198X
Keywords:
Key words Blood pH
;
Titratable acidity
;
Compensatory renal growth
;
Immunosuppression
;
Nephrectomy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of cyclosporin A (CyA, 50 mg/kg body weight) or its commercial vehicle (cremophor) on the acid-base regulation of uninephrectomized rats were assessed for 7 days and in non-nephrectomized rats for 15 days. CyA induced a marked systemic acidosis, accompanied by decreases in blood PCO2 and plasma bicarbonate. Untreated uninephrectomized rats did not show the acidosis. In CyA-treated rats the urine pH decreased (control 6.65±0.06 vs. CyA 6.18±0.08; P〈0.01) as well as urinary bicarbonate (non-nephrectomized rats 7.50±1.88 mM vs. uninephrectomy plus CyA 0.75± 0.06 mM; P〈0.01), suggesting partial renal compensation of systemic acidosis. Titratable acidity increased in CyA-treated rats (control 21.6±1.2 vs. CyA 63.3±12.0 µEq/l; P〈0.001). Phosphate, glucose, and osmolar clearances were not significantly altered in non-nephrectomized rats treated with CyA for 15 days. There was a striking decrease in body weight in CyA-treated rats (control 274.0±3.8 vs. CyA 225.0±5.1 g; P〈0.01), but compensatory growth of the remaining kidney was not prevented by this drug or by its vehicle. In summary, CyA induced a severe metabolic acidosis in uninephrectomized rats that was not compensated by the remaining kidney, in spite of the well-preserved compensatory weight gain of this organ. Loss of body weight was significant in CyA-treated animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004670050026
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