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  • 2000-2004  (2)
  • DOC  (1)
  • Keywords Cw6  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Stronger association with HLA-Cw6 than with corneodesmosin (S-gene) polymorphisms in Swedish psoriasis patients (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 525-530 
    Details
    ISSN: 1432-069X
    Keywords: Keywords Cw6 ; HLA antigens ; Linkage ; disequilibrium ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Psoriasis vulgaris is strongly associated with certain human leukocyte antigens, especially in early onset. The purpose of this study was to study the HLA-Cw6 allele and its contribution to disease susceptibility in a set of 104 families with at least two affected siblings. A sequencing method was utilized to examine the two exons that build up the antigen binding site of the C locus receptor. DNA from patients homozygous for Cw6 based on haplotype information were sequenced. The results confirmed the identity of the Cw6 allele in affected individuals with the consensus sequence for Cw*0602. We screened the set of families for psoriasis patients homozygous for Cw6 and found 11 individuals with a mean age at onset of 16.1 years. The corresponding figure for the Cw6 heterozygotes was 18.45 years and for the Cw6-negatives 22.36 years. This is indicative of a gene dose effect. We performed a transmission disequilibrium test (TDT) on the Cw6 allele per se, used as a biallelic marker. The analysis resulted in a P-value of 5.3 × 10–17 (t167/nt45). This greatly exceeds our previous results of a TDT in the region, including microsatellite markers and single nucleotide polymorphisms (SNPs) in the coding part of the S gene (corneodesmosin), which is a suggested candidate gene in the region. The maximum nonparametric linkage (NPL) value was also reached using HLA-C as a marker. We conclude that Cw6 is the allele which shows the highest degree of association with psoriasis in our set of families and we propose that it directly influences the age at onset of the disease rather than increasing the genetic load in accordance with a polygenic theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000175
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Calcium content of liming material and its effect on sulphur release in a coniferous forest soil (2000)
    Springer
    Biogeochemistry 50 (2000), S. 1-20 
    Details
    ISSN: 1573-515X
    Keywords: calcium content ; DOC ; liming material ; pH ; podsol ; sulphur mineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Soil columns with O + A (Experiment I) or Ohorizons (Experiment II) from a Haplic Podsol wereincubated at 15 °C for 368 and 29 + 106 days,respectively. Three types of liming material differingin Ca2+ content, i.e. calcium carbonate(CaCO3), dolomite (CaMg(CO3)2) andmagnesium carbonate (MgCO3), were mixed into theO horizons in equimolar amounts corresponding to 6000kg of CaCO3 per ha. In the limed treatments ofExperiment I, the leaching of dissolved organic carbon(DOC) and the net sulphur mineralization (estimated asaccumulated SO 4 2− leaching corrected forchanges in the soil pools of adsorbed and waterextractable SO 4 2− ) increased with decreasingCa2+ content of the lime and increasing degree oflime dissolution. In relation to the controltreatment, only the MgCO3 treatment resulted ina significantly higher net sulphur mineralization. InExperiment I the net sulphur mineralization was 4.06,1.68, 0.57, and 2.14 mg S in the MgCO3,CaMg(CO3)2, CaCO3 and control treatment,respectively. The accumulated SO 4 2− leachingin Experiment II during the first 29 days was 1.70,0.74 and 0.48 mg S in the MgCO3,CaMg(CO3)2 and control treatment,respectively. In the two experiments there wereconsistently significant positive correlations betweenleached amounts of SO 4 2− and DOC. It wasconcluded that net sulphur mineralization was stronglyconnected to the solubilization of the organic matter(DOC formation) and that pH and/or Ca2+ ionsaffected the net sulphur mineralization through theireffects on organic matter solubility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006355532514
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    Paper (German National Licenses)
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