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  • 2000-2004  (2)
  • Medical factors  (1)
  • Platelet-derived endothelial cell growth factor  (1)
  • Disseminated intravascular coagulation
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  • 1
    ISSN: 1437-160X
    Keywords: Key words Gliostatin ; Thymidine phosphorylase ; Platelet-derived endothelial cell growth factor ; Rheumatoid arthritis ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neovascularization, proliferation of synovial cells, and mononuclear cell influx and activation are characteristic events observed in synovial joints in the pathohistology of rheumatoid arthritis (RA). The objective of this study was to examine synovial inflammation in rabbit knees induced by intra-articular administration of human gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF), which shares a high degree of chemical homology with thymidine phosphorylase (dThdPase) and is known to have angiogenic activity. Purified recombinant human gliostatin (rHuGLS) and its mutant protein, which was prepared by site-directed mutagenesis and which lacks dThdPase activity, were administered at various doses to rabbit knee joints. The effects of rHuGLS and the mutant were examined histologically. Intra-articular injection of rHuGLS resulted in the development of diffuse synovitis resembling RA. The mutant protein also brought about the same effect. These findings suggest that human GLS can cause RA-like synovitis in rabbit knee joints via a mechanism other than its dThdPase activity.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-7609
    Keywords: Key words Systemic lupus erythematosus ; Emotional instability ; Social factors ; Medical factors ; Physical factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-four female outpatients with systemic lupus erythematosus (SLE) who are able to live on their own were investigated. We statistically analyzed the relationship between emotional instability based on psychological tests (Cornell Medical Index), and physical, medical, and social factors based on both our clinical records and original questionnaires. The emotional instability was related to not "working," an older "age at the time of SLE diagnosis," being "anxious about the adverse effects of steroids," or not "understanding the details of the disease and treatment at the time SLE treatment was started." No relationship with previously experienced physical factors was observed. In addition, no relationship with disease activity was observed either. We identified the characteristic correlation between emotional instability and medical and social factors in this study. Paying close attention to these factors may thus be useful in both preventing the appearance of psychological problems and developing effective early treatment strategies.
    Type of Medium: Electronic Resource
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