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  • 2000-2004  (2)
  • Glutamate dehydrogenase  (1)
  • Key words Soluble HLA I (sHLA)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The quality of a liver graft (2000)
    Springer
    Transplant international 13 (2000), S. S288 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver graft quality ; Effluates ; Prediction of survival ; Glutathione S-transferase ; Glutamate dehydrogenase ; Leucocyte count
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because transplantation success is influenced by the quality of the graft, the objective of this study was to find parameters to evaluate transplant livers in the recipient centre. In 64 liver grafts, the venous effluates of a portal back-table flush were investigated for various parameters. Amongst them, glutathione S-transferase (GST), glutamate dehydrogenase (GLDH) and the leucocyte count were found superior in predicting graft survival. Using the combination of these parameters, 100-day graft survival of between 95 % (all parameters positive) and 0 % (all parameters negative) was predicted. We concluded that good liver grafts are characterized by a low width of injury (cytosolic component: GST), a low depth of injury (mitochondrial component: GLDH), as well as by a potential to induce tolerance (passenger leucocytes). Perfusate analysis seems to be a valuable tool to recognize problematic grafts in advance and to quantify the “graft factor” in considerations concerning quality control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050344
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of perioperative sHLA I concentrations on the histological development of the liver graft (2000)
    Springer
    Transplant international 13 (2000), S. S449 
    Details
    ISSN: 1432-2277
    Keywords: Key words Soluble HLA I (sHLA) ; Flush catheter ; Rejection ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Soluble HLA I (sHLA I) in human serum are ascribed an immunoregulatory role in the context of organ transplantation. Based on histological findings, the objective of the current study was to evaluate the protective influence of sHLA I in liver transplantation from the time point of reperfusion. The sHLA I concentrations in serum samples derived from the liver vein immediately after reperfusion (flush catheter) of 38 patients with liver transplantations were determined by ELISA. The postoperative histological findings of the transplant biopsies were categorized according to rejection, endothelialitis, cholestasis, and necrosis, as well as fatty degeneration. An evaluation according to Kaplan-Meier showed a lower incidence for all of these factors in liver grafts with high sHLA concentrations (P 〈 0.05). We conclude that low sHLA I concentrations during reperfusion correlate with later complications, thus indicating that sHLA I may have protective potential in liver transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050380
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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