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  • 2000-2004  (3)
  • Helianthus annuus  (1)
  • Key words Vascular complications  (1)
  • Mycophenolate mofetil  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Use of tacrolimus and mycophenolate mofetil as induction and maintenance in simultaneous pancreas-kidney transplantation (2000)
    Springer
    Transplant international 13 (2000), S. S191 
    Details
    ISSN: 1432-2277
    Keywords: Key words Induction therapy ; Tacrolimus ; Simultaneous pancreas-kidney transplantation ; Acute rejection ; Mycophenolate mofetil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical trials using quadruple immunosuppression that include the combination of tacrolimus and mycophenolate mofetil have been shown to reduce the incidence of acute rejection episodes in simultaneous pancreas-kidney (SPK) transplantation. In an attempt to obtain a low rejection rate without antibody induction therapy, we undertook a prospective study of combined tacrolimus and mycophenolate mofetil and steroids as primary immunosuppression for SPK transplantation. In this study, we analyzed 17 patients who received low-dose intravenous tacrolimus as induction therapy. This was combined with oral tacrolimus, mycophenolate mofetil, and steroids as the primary immunosuppression regimen. There was a significant reduction of empirically and biopsy-proven rejection with an incidence of 23 % (4 patients). Leukopenia, gastroparesis, and gastrointestinal side-effects were the cause of discontinuation of mycophenolate mofetil, or low tacrolimus trough level in those patients who developed rejection. All rejection episodes were easy to treat, and none of them required antibody therapy. The combination of tacrolimus with mycophenolate mofetil without antibody induction therapy is effective in preventing early acute rejection. This combination is safe and effective as an alternative immunosuppressive regimen after SPK transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050323
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Vascular complications following bladder drained, simultaneous pancreas-kidney transplantation: the University of Miami experience (2000)
    Springer
    Transplant international 13 (2000), S. S187 
    Details
    ISSN: 1432-2277
    Keywords: Key words Vascular complications ; Pancreas-kidney transplant ; Thrombosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vascular complications remain a significant nonimmunologic source of pancreas allograft loss. From February 1993 through January 1998, we performed 98 simultaneous pancreas-kidney transplantations (SPK) using pancreatic exocrine bladder drainage in patients with type 1 insulin-dependent diabetes mellitus and end-stage renal disease. They originally received quadruple immunosuppression, and since May 1997 triple immunosuppression protocol (tacrolimus, mycophenolate mofetil, and steroids). The patients' mean age was 37 years (range 24–53 years), including 50 women and 48 men with a mean follow-up of 42 months. The overall rate of vascular complications was 6 % (5 patients). The vascular complications were as follows: late thrombosis of the Y with persistent pancreas allograft function (n = 1), rupture of a pseudoaneurysm of the superior mesenteric artery (PSMA) with an arteriovenous fistula (AVF) (n = 1), thrombosis of the splenic vein (SV) (n = 3), complete thrombosis of the superior mesenteric vein (SMV) and splenic vein (n = 1). The patient with PSMA underwent surgical correction of the AVF and PSMA with preservation of the allograft pancreas function. The other patient with late thrombosis of the Y-graft required no treatment. All 3 patients with SV thrombosis were systemically heparinized followed by oral anticoagulation. The patient with complete thrombosis required surgical thrombectomy of the SMV and SV followed by heparinization and oral anticoagulation. All 6 patients including the 4 with thrombosis had preservation of the pancreas function. Serial pancreas ultrasound showed resolution and improvement with recanalization of the splenic vein and superior mesenteric vein in those patients with thrombosis. We describe our vascular experience with salvage of the pancreatic allograft function. Surgery seems to be the best treatment option in the case of AVF or complete thrombosis of the allograft. Intravenous heparin followed by oral anticoagultion could be a conservative approach for SV thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050322
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic distance as a predictor of heterosis and hybrid performance within and between heterotic groups in sunflower (2000)
    Springer
    Theoretical and applied genetics 100 (2000), S. 889-894 
    Details
    ISSN: 1432-2242
    Keywords: Key words Heterosis ; Genetic distance ; Sunflower ; Helianthus annuus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Heterosis is significant for seed yield and is one of the driving forces behind the hybrid seed industry in cultivated sunflower (Helianthus annuus L). Heterotic groups in sunflower, if any other than the female and male inbred-line groups exist, have not been well studied or described. The primary aims of this study were to assess the utility and validity of a series of proposed heterotic groups and estimate correlations between genetic distance, heterosis, and hybrid performance for seed yield in sunflower. Fortytwo female by male heterotic group (A × R) and 81 female by female heterotic group (A × B) single-cross hybrids were grown in Corvallis, Ore., and Casselton, N.D., in 1996 and 1997. Heterosis was significant for seed yield and plant height but not for seed oil concentration and days to flowering. Genetic distances were significantly correlated with hybrid seed yield when estimated from AFLP fingerprints (G D) (r = 0.63 for A × R and 0.79 for A × B hybrids), but not from coancestries (G C) (r = -0.02 for A × R and 0.54 for A × B hybrids). G D (R 2 = 0.4) was a poor predictor of hybrid seed yield. The proposed heterotic groups in sunflower seem to have utility, but do not seem to be as strongly differentiated as those in corn (Zea mays L.). The highest-yielding hybrids were from the BC× RB heterotic pattern; however, several BC× BC hybrids (within-group hybrids) were among the top-yielding hybrids. The outstanding performance of certain BC× BC hybrids casts some doubt on the validity of the BC group. Substantial genetic diversity seems to be present within and between heterotic groups in sunflower.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051366
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    Paper (German National Licenses)
    Fulltext
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