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  • 1
    Digitale Medien
    Digitale Medien
    High 5HT2A receptor occupancy in M100907-treated schizophrenic patients (2000)
    Springer
    Psychopharmacology 148 (2000), S. 400-403 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words Serotonin receptor ; 5HT2A ; M100907 ; [11C]M100907 ; Positron emission tomography ; PET ; Human brain ; Schizophrenia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Rationale: Selective drugs are required to test the hypothesis whether antipsychotic effects may be induced or modulated by 5HT2A receptor antagonism. M100907 (previously known as MDL 100,907) is a highly selective 5HT2A antagonist in clinical development. Objective: To test if the suggested clinical dose of 20 mg M100907 daily induces high 5HT2A receptor occupancy in patients with schizophrenia. Methods: The 5HT2A receptor occupancy was determined in two patients with schizophrenia treated with M100907, 20 mg once a day. Positron emission tomography (PET) with 11C-labeled M100907, was performed prestudy and under steady state conditions. Clinical ratings were performed weekly. Results: Clinical treatment with M100907, 20 mg daily induced a very high 5HT2A receptor occupancy in the frontal cortex of both patients (〉90%). M100907 was well tolerated. One patient improved minimally and one patient became minimally worse during treatment. Conclusions: The results confirm that an oral dose of 20 mg per day ensures adequate 5HT2A receptor occupancy for clinical proof of concept. The sample is too small to allow conclusions about the clinical effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050069
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Congenital balloon digits in two neonates caused by constriction rings (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 533-535 
    Details
    ISSN: 1437-9813
    Schlagwort(e): Key words Balloon digit ; Constriction ring ; Neonate ; Lymphatic vessel ; Fibrous tissue
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Balloon digits were found in two neonates with congenital constriction ring syndrome. The affected digits were the right long finger and right great toe. They were surgically treated at the age of 10 and 9 days, respectively. Morphologic improvement was dramatic after surgery. In cases with extensive enlargement, severe cyanosis, redness, and no subsidence of edema within several days after birth, early operative treatment may be necessary to maintain digit viability and prevent autoamputation due to circulatory embarrassment. It can also be helpful to prevent fibrosis of the subcutaneous tissue. Pathologic examination revealed marked proliferation of fibrous tissue and lymphatic vessels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003839900330
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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