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  • 2000-2004  (2)
  • Microarray Gene expression Structural analysis Geometry  (1)
  • client/therapist relationship  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Functional & integrative genomics 1 (2000), S. 174-185 
    ISSN: 1438-7948
    Keywords: Microarray Gene expression Structural analysis Geometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. A microarray experiment gives a snapshot of the state of an organism in terms of the relative abundances of its mRNA transcripts, locating the organism at a point in a high dimensional state space where each axis represents the relative expression level of a single gene. Multiple experiments generate a cloud of points in this gene expression space. We present a geometric approach to analyzing the covariational properties of such a cloud and use a dataset from Saccharomyces cerevisiae as an illustration. In particular, we use singular value decomposition to identify significant linear sub-structures in the data and analyze the contributions of both individual genes and functional classes of genes to these major directions of variation. Analyzing the publicly available yeast expression data, we show that under all experimental conditions the variation in expression is limited to a small number of linear dimensions. Projections of individual gene axes onto the significant dimensions can order the contribution of individual genes to variation in expression within an experiment. We show that no particular groups of genes characterize particular experimental conditions. Instead, the particular structure of the coordinated expression of the entire genome characterizes a particular experiment.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-3335
    Keywords: marital and family therapy ; client/therapist relationship ; clinical interviewing ; process research
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract A therapy research team interviewed a therapist in the presence of a couple. Following each of six consecutive sessions with a couple, an interviewer posed questions to the therapist and couple. While one question was standard to each interview, other questions were generated by team members who tracked the entire process via live observation. These questions were directed first at the therapist, then at the couple, and then focused on therapeutic process and outcome. Findings of this process for the therapy system included decreasing the hierarchy within the client/therapist relationship; increasing the client ownership and energy in the therapy process; discovering the presence of parallel processes between the systems; and informing the direction of future therapy sessions. Practical, clinical implications are discussed for a variety of therapy settings.
    Type of Medium: Electronic Resource
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