ISSN:
1573-9171
Keywords:
CH-acids
;
6H-indeno[1,2-b]quinoline, heterogeneous catalytic dehydrogenation, thermogravimetric and X-ray structural analysis
;
interferon-inducing and antitumor intercalators
;
topological factor
;
stacking structures
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Based on thermogravimetric characteristics first obtained for the model 6H-indeno [1,2-b]quinoline, the scheme of thermal conversions of this compound in the temperature range 20–700 °C has been proposed, and the limit of its thermal stability (∼300 °C) has been determined. This temperature is recommended as the optimum for synthesizing fused benzoaza(diaza)fluorenes. Based on the results of X-ray structural analysis, the molecules of the studied indenoquinoline form centrosymmetric pairs, which are arranged in (110) layers. The molecules are orientationally disordered. The observed self-association of these molecules is similar to the π-π association of fused heterocyclic systems withπ-excessive andπ ****- deficient fragments. It has been suggested that interferon-inducing and antitumor compounds with an annelated indenyl fragment have a common mechanism of action according to the intercalation model of stacking structures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00698503
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