Electronic Resource
Oxford, UK
:
Blackwell Science Ltd
Histopathology
44 (2004), S. 0
ISSN:
1365-2559
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The introduction of new technologies, designed to assess biologically relevant alterations in tumour cells, has the potential to provide additional prognostic and predictive information from biopsies, as well as providing a more objective assessment than conventional histopathology alone. One such technique is the assessment of the ploidy status of tumours. DNA ploidy studies, using various technologies, are abundant in the literature, but questions remain as to how such studies should be translated into evidence-based practice. In this Expert Opinion, we provide two perspectives on this field. Baak and Janssen discuss the technology and set the assessment of ploidy in the context of other quantitative techniques. Clinical applications are then illustrated. In the paper by Peter Hall, aspects of the biology of ploidy are discussed, and the potential relevance of a more detailed understanding of the biology of ploidy to clinical application. Some of the general short-comings of the applied literature are discussed and some approaches suggested for the improvement of the evidence base on which healthcare decisions relating to the application of new technologies are made.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2559.2004.01897.x
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