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Digitale Medien

STRUCTURES AND PROTON-PUMPING STRATEGIES OF MITOCHONDRIAL RESPIRATORY ENZYMES (2001)

Schultz, Brian E. ; Chan, Sunney I.

Palo Alto, Calif. : Annual Reviews

Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 23-65

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ISSN: 1056-8700

Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Thema: Biologie , Physik

Notizen: Abstract Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the production of ATP. The ATP synthase enzyme is reversible and can also serve as a proton pump by coupling ATP hydrolysis to proton translocation. Each of the respiratory enzymes uses a different strategy for performing proton pumping. In this work, the strategies are described and the structural bases for the action of these proteins are discussed in light of recent crystal structures of several respiratory enzymes. The mechanisms and efficiency of proton translocation are also analyzed in terms of the thermodynamics of the substrate transformations catalyzed by these enzymes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1146/annurev.biophys.30.1.23

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Digitale Medien

ESEEM studies of succinate:ubiquinone reductase from Paracoccus denitrificans (2000)

Hung, Shao-Ching ; Grant, Christopher V. ; Peloquin, Jeffrey M. ; [weitere]

Springer

JBIC 5 (2000), S. 593-602

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ISSN: 1432-1327

Schlagwort(e): 2Fe-2S cluster 4Fe-4S cluster 3Fe-4S cluster Flavin semiquinone radical Electron spin-echo envelope modulation spectroscopy

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Abstract. Electron spin-echo envelope modulation (ESEEM) spectroscopy has been performed in order to obtain structural information about the environment of the reduced [2Fe-2S] cluster (S-1 center), the oxidized [3Fe-4S] cluster (S-3 center), and the flavin semiquinone radical in purified succinate:ubiquinone reductase from Paracoccus denitrificans. Spectral simulations of the ESEEM data from the reduced [2Fe-2S] yielded nuclear quadrupole interaction parameters that are indicative of peptide nitrogens. We also observed a weak interaction between the oxidized [3Fe-4S] cluster and a peptide 14N. There was no evidence for coordination of any of the Fe atoms to 14N atoms of imidazole rings. The ESEEM data from the flavin semiquinone radical were more complicated. Here, evidence was obtained for interactions between the unpaired electron and only the two nitrogen atoms in the flavin ring.