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  • 2000-2004  (2)
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  • 1
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Polymorphisms within the β subunit of the high-affinity receptor for IgE (FcεR1-β) on chromosome 11q13 have been related to atopy and asthma and the lymphotoxin α (LTα) gene on chromosome 6 is implicated in asthma.Objective To elucidate the association of polymorphisms in the FcεR1-β and LTα genes to IgE responses and asthma in a family-orientated rural population.Methods A total of 461 adult farmers, who participated in an epidemiological follow-up study on respiratory symptoms among farmers on the Swedish island of Gotland, were examined. The traits assessed included serum total IgE, IgE antibody responses to 21 common inhalant allergens and asthma.Results The 237G mutation was only detected in seven persons. Atopy was found to be associated with the RsaI-ex7 AB-genotype (OR = 1.9; P = 0.04). The RsaI-ex7 B allele had a significant influence on IgE responses to pollens and dust mites (OR = 5.5; P = 0.03 and OR = 5.2; P = 0.049, respectively). The influence of this allele was stronger when the association towards single dust mite species (Lepidoglyphus destructor) was estimated (OR = 7.1, P = 0.03) and the association increased even more when the major allergen of L. destructor (rLep d 2) was analysed (OR = 11.2, P = 0.02). These associations were independent of sex, age and smoking, and the estimates of RsaI-in2 independent of RsaI-ex7. RsaI-in2, RsaI-ex7 and LTα genotypes were unassociated with total serum IgE. No significant difference in the distribution of RsaI-in2, RsaI-ex7 and LTα genotypes was found among subjects with atopy or asthma compared to healthy controls.Conclusion This study supports the notion that polymorphisms in the FcεR1-β gene have significant effects on IgE responsiveness. Secondly, dust mites in rural populations influence the expression of genes on chromosome 11q13.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford UK : Blackwell Science Ltd
    Grass and forage science 55 (2000), S. 0 
    ISSN: 1365-2494
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Responses of perennial ryegrass (Lolium perenne L.) to nitrogen (N) fertilizer application rates and timings vary widely, because water is often limiting. Yield response to N fertilizer application during autumn, late-winter and spring, and the associated efficiency of use of these inputs, was assessed under conditions of non-limiting soil moisture during two, one-year lysimeter studies in Canterbury, New Zealand. There were significant (P 〈 0·05) increases in seed and herbage yields with increasing N fertilizer application. Seed yields differed with year; greatest yields were 300 g m−2 in 1996 and 450 g m−2 in 1997. Seed head numbers (r2=0·77), seeds head−1 (r2=0·92) and herbage yield (r2=0·92) were the major determinants of seed yield in both years. Irrigation required to maintain the soil between 70% and 90% of field capacity was directly related (r2=0·94 and 0·99 in 1996 and 1997 respectively) to increases in herbage yield.Seed yield, seed quality (thousand seed weight and percentage of seed 〉 1·85 mg), efficiency of water use, efficiency of N fertilizer use and apparent N fertilizer recovery were greatest when N fertilizer was applied at a rate of 50 kg N ha−1, 50 or 100 kg N ha−1 and 150 kg N ha−1 in autumn, late-winter and spring respectively; further increases in spring N fertilizer stimulated vegetative growth, but not seed yield.As a management strategy, applying N fertilizer to match the N requirements of the crop during the reproductive stage of growth will result in high yields of high quality seed while minimizing environmental impact.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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