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  • 2000-2004  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Cardiac Tamponade Rapidly Evolving Toward Constrictive Pericarditis and Shock as a First Manifestation of Noncardiac Cancer (2004)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 19 (2004), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  A 44-year-old man presented with symptoms and signs of cardiac tamponade. Cytologic examination of the pericardial fluid was negative for malignancy and no manifestations of primary tumor were detected. Two weeks after pericardiocentesis the patient developed constrictive pericarditis. An emergency exploratory thoracotomy revealed a thick, fibrotic pericardium firmly adherent to the underlying myocardium. Histologic examination of the pericardium showed the presence of an adenocarcinoma, suspected to be a metastatic dissemination from a primary pulmonary source. The lymphatic spread of the tumor to the heart may explain the early development of pericardial effusion without malignant cells and the later development of pericardial and epicardial thickening. Cardiac tamponade of unknown origin should prompt a search for metastatic carcinoma, including in presence of a negative cytology. (J Card Surg 2004;19:134-135)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04025.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    STRUCTURE, FUNCTION, AND INHIBITION OF CHEMOKINES (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 42 (2002), S. 469-499 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Abstract Chemokines are the largest family of cytokines in human immunophysiology. These proteins are defined by four invariant cysteines and are categorized based on the sequence around the first two cysteines, which leads to two major and two minor subfamilies. Chemokines function by activating specific G protein-coupled receptors, which results in, among other functions, the migration of inflammatory and noninflammatory cells to the appropriate tissues or compartments within tissues. Some of these proteins and receptors have been implicated or shown to be involved in inflammation, autoimmune diseases, and infection by HIV-1. The three-dimensional structure of each monomer is virtually identical, but the quaternary structure of chemokines is different for each subfamily. Structure-function studies reveal several regions of chemokines to be involved in function, with the N-terminal region playing a dominant role. A number of proteins and small-molecule antagonists have been identified that inhibit chemokine activities. In this review, we discuss aspects of the structure, function, and inhibition of chemokines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pharmtox.42.091901.115838
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Increased Variance of P Wave Duration on the Electrocardiogram Distinguishes Patients with Idiopathic Paroxysmal Atrial Fibrillation (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 23 (2000), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We hypothesized that the variance of P wave duration (P variance) in the 12-lead ECG could reflect the spatial dispersion of P wave duration due to inhomogeneous and delayed propagation of sinus impulses in the atria, and moreover could present better reproducibility than maximum P wave duration and P wave dispersion that have already been used for the prediction of idiopathic paroxysmal AF, We also tested a semiautomated PC-based method to improve the accuracy and reproducibility of P wave measurements. A 12-lead ECG was obtained from 60 patients with idiopathic paroxysmal AF and from 50 healthy controls. All ECGs were analyzed manually using magnifying lens and calipers, while 20 randomly selected ones were scanned and analyzed on screen using common commercial software. P maximum, P dispersion, and P variance were all significantly higher in patients with paroxysmal AF than in controls. A P maximum value of 110 ms, a P dispersion value of 40 ms, and a P variance value of 120 ms2 separated patients from controls with a sensitivity of 88%, 83%, and 80%, respectively and a specificity of 75%, 85%, and 74%, respectively. The reproducibility of P variance was higher compared to P dispersion and P maximum. Finally, the PC-based method significantly increased accuracy and reproducibility of P wave measurements. Thus, the variance of P wave duration could be a useful ECG marker for the prediction of paroxysmal idiopathic AF and the use of PC-based methods may enhance the accurate measuring of P wave duration on the ECG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.2000.tb00913.x
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical and Electrocardiographic Predictors of Recurrent Atrial Fibrillation (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 23 (2000), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients with frequent episodes of paroxysmal atrial fibrillation (AF) are prone to develop permanent AF and have an increased thromboembolic risk. We have previously shown that P wave dispersion (P dispersion), defined as the difference between the maximum and the minimum P wave duration, and maximum P wave duration (P maximum) can distinguish patients with paroxysmal lone AF. The ability of those ECG markers and of other clinical and ECG variables to detect patients at risk for recurrent AF was tested in 88 patients, aged 64 ± 12 years. All patients had a history of symptomatic episodes of AF during the last 2 years and had not previously received any antiarrhythmic prophylaxis. P maximum and P dispersion were calculated from a 12-lead surface ECG recorded in all patients during sinus rhythm. A computerized ECG system was used and P maximum and P dispersion were calculated on screen from the averaged complexes of all 12 leads. Age (P=0.01), history of organic heart disease (P = 0.03), P maximum (P 〈 0.001), minimum P wave duration (P = 0.05), and P dispersion (P 〈 0.001) were found to be significant univariate predictors of recurrent AF, whereas only P maximum (P 〈 0.001) and age (P = 0.037) remained significant independent predictors of frequent AF paroxysms in the multivariatfi analysis. It is concluded that advanced age and prolonged P wave duration may be used as predictors of frequently relapsing AF. Therefore, simple AF predictors exist that could possibly distinguish the patients in whom prophylaxis with antiarrhythmic medicines should be instituted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.2000.tb06761.x
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  • 5
    Electronic Resource
    Electronic Resource
    P Wave Analysis Indices in Young Healthy Men: Data from the Digital Electrocardiographic Study in Hellenic Air Force Servicemen (DEHAS) (2003)
    350 Main Street , Malden , MA 02148-5018 , USA . : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 26 (2003), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: GIALAFOS, E.J., et al.: P Wave Analysis Indices in Young Healthy Men. Data from the Digital Electrocardiographic Study in Hellenic Air Force Servicemen (DEHAS). P wave analysis from the 12-lead ECG is a recent contribution of noninvasive electrocardiology. P wave analysis indices (maximum and minimum P wave duration, P wave dispersion [Pdis= Pmax− Pmin], adjusted P wave dispersion [APdis= Pdis/√measured leads], summated P wave duration [Psum], standard deviation of P wave duration [Psd], mean P wave duration [Pmean]) can predict atrial arrhythmias. However, the definitions of all these indices are based on few studies. The aim of this analysis was to define normal values of these indices and the examine possible associations between P wave indices and clinical variables. The study included 1,353 healthy men, 24 ± 3 years of age, who answered a questionnaire and underwent a detailed physical examination and a digitized 12-lead surface ECG. All P wave indices were analyzed by two independent investigators. Mean values of the ECG indices were: Pmax: 96 ± 11 ms, Pmin: 57 ± 9 ms, Pdis: 38 ± 10 ms, Psum: 924 ± 96 ms, Psd: 12 ± 3,APdis: 11 ± 3 ms, and Pmean: 77 ± 8 ms . Age was significantly related with Pmax (r = 0.277, P 〈 0.01), Pmin (r = 0.255, P 〈 0.001), Psum (r = 0.074, P 〈 0.01), and Pmean (r = 0.074, P 〈 0.01) . All ECG indices were significantly associated with the R-R interval, and among each other. This study defined normal indices of wave duration and correlations among them. These markers may play an important predictive role in patients with atrial conduction abnormalities. (PACE 2003; 26[Pt. II]:367–372)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2003.00051.x
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  • 6
    Electronic Resource
    Electronic Resource
    A cryocooling technique for protein crystals grown by dialysis from volatile solvents (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 168-171 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The transfer of protein crystals from the original crystallization environment to cryoprotectants, heavy-atom solutions, or quartz capillary tubes, exposes crystal droplets to conditions that can cause evaporation of the droplet and damage to the crystal. This problem is particularly acute for crystals grown from volatile solvents or that are otherwise air-sensitive. Here a method that overcomes this problem is applied to crystals of macrophage inflammatory protein II encoded by herpesvirus-8. The method is based on dialysis and makes use of a dialysis adaptor that can be used with 24-well crystallization plates. This method permits the transfer of crystals to cryoprotectant conditions with greater ease and lowers the risk of mechanical damage relative to other available methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889899012406
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