Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Respiratory Changes in Vasovagal Syncope (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 11 (2000), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Respiratory Changes in Vasovagal Syncope. introduction: Respiratory changes accompany the cardiovascular changes during head-up. tilt test-induced vasovagal syncope. Methods and Results: Using the 45-minute 60° head-up Westminster protocol, 29 patients were studied (mean age 53.9 ± 20.0 years; 19 females). Two groups resulted: tilt-induced vasovagal syncope positive and negative. The cardiorespiratory parameters blood pressure (BP), heart rate (HR), tidal volume, and minute volume were measured. Comparisons of the cardiorespiratory parameters were made within the positive group and negative group, and then between the two groups. There were 14 in the positive group and 15 in the negative group. Baseline measurements were normalized to 1.0. Comparing the late tilt periods between the positive and negative groups, there were differences in BP (P 〈 0.002), HR (P 〈 0.002), tidal volume (P 〈 0.05), and minute volume (P 〈 0.002). In the positive group comparing early with late intervals: BP l.11 ± 0.09 versus 0.49 ± 0.17, P 〈 0.0001; HR 1.18 ± 0.12 versus 0.85 ±0.35, P 〈 0.009; tidal volume 1.39 ± 0.34 versus 2.17 ± 1.00, P 〈 0.015; and minute volume 1.24 ± 0.26 versus 3.3 ± 2.03, P 〈 0.0025. There were no comparable cardiorespiratory changes in the negative group. Conclusion: There were significant differences in the respiratory and cardiovascular parameters measured between those who were positive and those who were negative for tilt-induced vasovagal syncope. Within the positive group, in addition to the falls in HR and BP, there were significant increases in minute volume and tidal volume during late tilt. This suggests that there may be a role for respiratory sensors in vasovagal syncope that may permit earlier and hence possibly more effective therapy for selected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.2000.tb00020.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Evidence for Expression of Some Microtubule-Associated Protein 1B in Neurons as a Plasma Membrane Glycoprotein (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 75 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Microtubule-associated protein (MAP) 1B is a high-molecular-weight cytoskeletal protein that is abundant in developing neuronal processes and appears to be necessary for axonal growth. Various biochemical and immunocytochemical results are reported, indicating that a significant fraction of MAP1B is expressed as an integral membrane glycoprotein in vesicles and the plasma membrane of neurons. MAP1B is present in microsomal fractions isolated from developing rat brain and fractionates across a sucrose gradient in a manner similar to synaptophysin, a well-known vesicular and plasma membrane protein. MAP1B is also in axolemma-enriched fractions (AEFs) isolated from myelinated axons of rat brain. MAP1B in AEFs and membrane fractions from cultured dorsal root ganglion neurons (DRGNs) remains membrane-associated following high-salt washes and contains sialic acid. Furthermore, MAP1B in intact DRGNs is readily degraded by extracellular trypsin and is labeled by the cell surface probe sulfosuccinimidobiotin. Immunocytochemical examination of DRGNs shows that MAP1B is concentrated in vesicle-rich varicosities along the length of axons. Myelinated peripheral nerves immunostained for MAP1B show an enrichment at the axonal plasma membrane. These observations demonstrate that some of the MAP1B in developing neurons is an integral plasma membrane glycoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0750553.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Objective measurements of radiotherapy-induced erythema (2004)
    Oxford, UK : Munksgaard International Publishers
    Skin research and technology 10 (2004), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: The development of acute radiation erythema is a common phenomenon among patients undergoing radiotherapy treatment. Because of the absence of reliable objective classification methods, the degree of skin reaction can at present mainly be judged subjectively in the clinic. This has motivated the present preliminary study, concerning the first steps in the development of an objective method for skin reaction classification.Methods: Three non-invasive techniques were used: near-infrared (NIR) spectroscopy, laser Doppler perfusion imaging and digital photography. The NIR spectra were analysed with principal component analysis (PCA), and the results from the other two with traditional univariate methods. Measurements were made on breast cancer patients who had been exposed to different irradiation doses. A total of 28 breast cancer patients participated one to three times each; 12 were treated with photons at 4 or 6 MeV and 16 were treated with high-energy electrons between 10 and 20 MeV to a maximum dose of 50 Gy.Results: PCA of NIR spectra shows that information on radiation dose lies mainly in the first principal component. It is observed that the higher the dose the higher the score value. The results from the laser Doppler measurements show that in 79% of the cases the perfusion increases significantly with radiation dose. Analysis of the digital photography shows that a proposed skin redness index (SRI), increases with a higher radiation dose. However, the increase in most cases is not significant. By combining all data, correlation to radiation doses was seen for 74% of the patients who participated more than once.Conclusion: All three non-invasive methods correlate with the radiation dose but to various degrees. NIR spectroscopy, laser Doppler and a combination of the three techniques are the most promising methods for characterising erythema.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0846.2004.00078.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Social Capital and the Internet: Evidence from Swiss Panel Data (2003)
    Oxford, UK and Boston, USA : Blackwell Publishing Ltd
    Kyklos 56 (2003), S. 0 
    Details
    ISSN: 1467-6435
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: A lively debate has recently emerged about the consequences of the diffusion of the Internet. While many social scientists emphasize the beneficial economic consequences of the Internet some suspect that it has also disadvantages for users’ social capital. So far the existing empirical evidence concerning the effect on social capital is mainly based on cross-sectional data and is still contradictory. This study is based on a longitudinal survey conducted in 1998 and 2001 among a random sample of Swiss citizens. It analyzes the determinants of the adoption of the Internet and the consequences for respondents’ personal networks as well as the time they spent socializing with their network. The results show that the Internet was adopted sooner by individuals with high financial, human and social capital. Furthermore, the results suggest that Internet use is not associated with a reduction in respondents’ networks or with the time they spent socializing with friends. Instead the findings suggest that the time users devote to the Internet is taken away from the time they spend on watching television.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0023-5962.2003.00224.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Immune Activation in the Intestinal Mucosa Before the Onset of Colitis in Gαi2-Deficient Mice (2000)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 52 (2000), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: G-protein subunit Gαi2-deficient mice spontaneously develop an inflammatory bowel disease that clinically and histopathologically resembles ulcerative colitis in humans. The aim of this study was to determine whether immunological changes precede the development of colitis in Gαi2-deficient mice. Therefore, Gαi2-deficient mice with no clinical or histopathological signs of colitis were compared with Gαi2-deficient mice with established colitis and wild-type animals, concerning immunological parameters. Healthy Gαi2-deficient mice displayed an increased frequency of CD4+ T cells and a decreased frequency of CD19+ B lymphocytes in the intestinal mucosa compared with control mice. The CD4+ population was characterized by a memory phenotype, i.e. increased expression of CD44 and decreased expression of CD45RB and CD62L, as well as increased expression of the mucosal homing receptors integrins α4β7 and αEβ7. Production of pro-inflammatory cytokines, interleukin (IL)-1β and interferon (IFN)-γ, were increased in Gαi2-deficient mice before clinical signs of disease were evident. In addition, total immunoglobulin (Ig)G and IgA levels in large intestinal secretions were increased significantly compared with wild-type mice, and antibodies specific for the normal intestinal flora in large intestinal secretions were present in Gαi2-deficient mice several weeks before the onset of colitis. In contrast, antibodies against tropomyosin, a putative autoantigen in human ulcerative colitis, were not found in Gαi2-deficient mice before the onset of colitis, although they were present in animals with established disease. In conclusion, activation of the intestinal immune system precedes histopathological and clinical signs of inflammation in Gαi2-deficient mice, suggesting that immune abnormalities play an important role in the induction of colitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2000.00759.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Tactile motion activates the human middle temporal/V5 (MT/V5) complex (2002)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 16 (2002), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The human middle temporal/V5 complex (hMT/V5) plays a central role in the perception of visual motion. This region is considered a unimodal visual area with little direct involvement of other sensory modalities. The current study uses H215O PET to test whether tactile motion influences the activity of hMT/V5. Regional cerebral blood flow (rCBF) within hMT/V5 was estimated in eight subjects in separate tactile motion and visual motion conditions, each contrasted with a resting, control. The tactile motion condition involved a brush stroked proximal-to-distal along the volar forearm and palm, while the subject attended to the stimulus with closed eyes. The visual motion condition consisted of low contrast, grey-scale rings radiating at 15°/s from a central point, upon which the subject was instructed to fixate. The location of hMT/V5 was defined for each subject separately as the local maximum of rCBF change during the visual motion condition (vs. control). The average change in rCBF within spherical regions of interest at each peak revealed significant bilateral activation of hMT/V5 in the tactile motion condition contrasted with a second, independent set of control scans. Additionally, a single subject received a sufficient number of scans to perform a pixel-wise, within-subject analysis. His functional images were coregistered to his anatomical MRI. In this subject, tactile motion produced a significant increase in rCBF that directly overlapped a region activated by visual motion at the posterior continuance of the inferior temporal sulcus, consistent with the known location of hMT/V5. These results suggest involvement of the hMT/V5 complex in tactile motion processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2002.02139.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Classification of human ovarian tumors using multivariate data analysis of polypeptide expression patterns (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 27 (2001), S. 68-68 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Quantitative molecular variation may be used for the development of methods for tumor classification. We used the statistical concept of principal component analysis to type ovarian tumors. We purified tumor cells from ovarian tumors and subjected them to two-dimensional gel electrophoresis. Using ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/87176
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Determining the Optimal Pacing Intervention Rate for Vasovagal Syncope (2000)
    Springer
    Journal of interventional cardiac electrophysiology 4 (2000), S. 585-589 
    Details
    ISSN: 1572-8595
    Keywords: vasovagal syncope ; pacing ; tilt testing ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Introduction: In this study, patients with rate hysteresis pacemakers implanted for vasovagal syncope were re-studied using serial tilt testing to determine whether, once triggered, pacing was more effective if the intervention rate was higher than the standard rate. Methods and Results: Twenty patients (mean age 55.4 years, range 23–81, 14 male) were studied, with randomisation to either initial standard rate (80–90[emsp4 ]beats/min) intervention, or to initial high rate (120[emsp4 ]beats/min) intervention. Although 18 of the 20 reported complete abolition of syncope since pacing, only 8 patients could be objectively assessed. The respective mean time to tilt down after symptom onset with standard and high rate intervention was 193±234[emsp4 ]s and 185±143[emsp4 ]s, (P 〉0.05). Conclusion: Repeat tilt testing was only of limited value in assessing the benefit of pacing. There was no advantage with high rate intervention in delaying the loss of consciousness (or intolerable symptoms) after the initial onset of symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026509430078
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Numerical dating of the Eckfeld maar fossil site, Eifel, Germany: a calibration mark for the Eocene time scale (2000)
    Springer
    Naturwissenschaften 87 (2000), S. 270-274 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract  Sediments of the Eckfeld maar (Eifel, Germany) bear a well-preserved Eocene fauna and flora. Biostratigraphically, Eckfeld corresponds to the Middle Eocene mammal reference level MP (Mammals Paleogene) 13 of the ELMA (European Land Mammal Age) Geiseltalian. In the maar crater, basalt fragments were drilled, representing explosion crater eruption products. By 40Ar/39Ar dating of the basalt, for the first time a direct numerical calibration mark for an Eocene European mammal locality has been established. The Eckfeld basalt inverse isochron date of 44.3±0.4 Ma suggests an age for the Geiseltalian/Robiacian boundary at 44 Ma and, together with the 1995 time scale of Berggren et al., a time span ranging from 49 to 44 Ma for the Geiseltalian and from 44 to 37 Ma for the Robiacian, respectively. Additional 40Ar/39Ar dating on a genetically related basalt occurrence close to the maar confirms a period of volcanism of ca. 0.6 m.y. in the Eckfeld area, matching the oldest Eocene volcanic activity of the Hocheifel volcanic field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001140050719
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Stream Invertebrate Communities, Water Quality, and Land-Use Patterns in an Agricultural Drainage Basin of Northeastern Nebraska, USA (2000)
    Springer
    Environmental management 26 (2000), S. 563-576 
    Details
    ISSN: 1432-1009
    Keywords: KEY WORDS: Biological assessment; Rapid bioassessment; Aquatic invertebrates; Riparian zone; Benthic invertebrates; Freshwater; River
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract We used invertebrate bioassessment, habitat analysis, geographic information system analysis of land use, and water chemistry monitoring to evaluate tributaries of a degraded northeast Nebraska, USA, reservoir. Bimonthly invertebrate collections and monthly water chemistry samples were collected for two years on six stream reaches to identify sources contributing to reservoir degradation and test suitability of standard rapid bioassessment methods in this region. A composite biotic index composed of seven commonly used metrics was effective for distinguishing between differentially impacted sites and responded to a variety of disturbances. Individual metrics varied greatly in precision and ability to discriminate between relatively impacted and unimpacted stream reaches. A modified Hilsenhoff index showed the highest precision (reference site CV = 0.08) but was least effective at discriminating among sites. Percent dominance and the EPT (number of Ephemeroptera, Plecoptera, and Trichoptera taxa) metrics were most effective at discriminating between sites and exhibited intermediate precision. A trend of higher biotic integrity during summer was evident, indicating seasonal corrections should differ from other regions. Poor correlations were evident between water chemistry variables and bioassessment results. However, land-use factors, particularly within 18-m riparian zones, were correlated with bioassessment scores. For example, there was a strong negative correlation between percentage of rangeland in 18-m riparian zones and percentage of dominance in streams (r 2 = 0.90, P 〈 0.01). Results demonstrate that standard rapid bioassessment methods, with some modifications, are effective for use in this agricultural region of the Great Plains and that riparian land use may be the best predictor of stream biotic integrity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002670010113
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...