ISSN:
0066-4219
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Medicine
Notes:
Abstract This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.med.54.101601.152421
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