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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 49 (2003), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: All parasites in the phylum Apicomplexa, including Toxoplasma gondii and Plasmodium falciparum, contain rhoptries, specialized secretory organelles whose contents are thought to be essential for successful invasion of host cells. Serine proteinase inhibitors have been reported to block host cell invasion by both T. gondii and P. falciparum. We describe the cloning and characterization of TgSUB2, a subtilisin-like serine proteinase, from T. gondii. Like its closest homologue P. falciparum PfSUB-2, TgSUB2 is predicted to be a type I transmembrane protein. Disruption of TgSUB2 was unsuccessful implying that TgSUB2 is an essential gene. TgSUB2 undergoes autocatalytic processing as it traffics through the secretory pathway. TgSUB2 localizes to rhoptries and associates with rhoptry protein ROP1, a potential substrate. A sequence within TgSUB2 with homology to the ROP1 cleavage site (after Glu) was identified and mutated by site-directed mutagenesis. This mutation abolished TgSUB2 autoprocessing suggesting that TgSUB2 is a rhoptry protein maturase with similar specificity to the ROP1 maturase. Processing of secretory organelle contents appears to be ubiquitous among the Apicomplexa. As subtilases are present in genomes of all the Apicomplexa sequenced to date, subtilases may represent a novel chemotherapeutic target.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    General relativity and gravitation 32 (2000), S. 313-327 
    ISSN: 1572-9532
    Keywords: Einstein–Langevin equations ; stochastic differential equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A generic four-dimensional dilaton gravity is considered as a basis for reformulating the paradigmatic Oppenheimer–Synder model of a gravitationally collapsing star modelled as a perfect fluid or dust sphere. Initially, the vacuum Einstein scalar-tensor equations are modified to Einstein–Langevin equations which incorporate a noise or micro-turbulence source term arising from Planck scale conformal, dilaton fluctuations which induce metric fluctuations. Coupling the energy-momentum tensor for pressureless dust or fluid to the Einstein–Langevin equations, a modification of the Oppenheimer–Snyder dust collapse model is derived. The Einstein–Langevin field equations for the collapse are of the form of a Langevin equation for a non-linear Brownian motion of a particle in a homogeneous noise bath. The smooth worldlines of collapsing matter become increasingly randomised Brownian motions as the star collapses, since the backreaction coupling to the fluctuations is non-linear; the input assumptions of the Hawking–Penrose singularity theorems are then violated. The solution of the Einstein–Langevin collapse equation can be found and is non-singular with the singularity being smeared out on the correlation length scale of the fluctuations, which is of the order of the Planck length. The standard singular Oppenheimer–Synder model is recovered in the limit of zero dilaton fluctuations.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    General relativity and gravitation 32 (2000), S. 1217-1240 
    ISSN: 1572-9532
    Keywords: Fokker—Planck equation ; Wheeler—deWitt equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract It is expected that quantum effects endow spacetime with stochastic properties near the Planck scale as exemplified by random fluctuations of the metric, usually referred to as spacetime foam or geometrodynamics. In this paper, a methodology is presented for incorporating Planck scale stochastic effects and corrections into general relativity within the ADM formalism, by coupling the Riemann 3-metric to white noise. The ADM—Cauchy evolution of a Riemann 3-metric h ij (t) induced on spacelike hypersurface C(t) can be interpreted within pure general relativity as a smooth geodesic flow in superspace, whose points consist of equivalence classes of 3-metrics. Coupling white noise to h ij gives Langevin stochastic differential equations for the Cauchy evolution of h ij, which is now a Brownian motion or diffusion in superspace. A fluctuation h′ij away from h ij is considered to be related to h ij by elements of the diffeomorphism group diff(C). Hydrodynamical Fokker—Planck continuity equations are formulated describing the stochastic Cauchy evolution of h ij as a probability flow. The Cauchy invariant or equilibrium solution gives a stationary probability distribution of fluctuations peaked around the deterministic metric. By selecting a physically viable ansatz for the scale dependent diffusion coefficient, one reproduces the Wheeler uncertainty relation for the metric fluctuations of quantum geometrodynamics. Treating h ij as a random variable, a non-linear Raychaudhuri—Langevin equation is derived describing the “geometro-hydrodynamics” of a congruence of fluid or dust matter propagating on the stochastic spacetime. For an initially converging congruence θ′〉0 at s′ the singularity θ=−∞ at future proper time s=3/|θ′|$, which is expected in general relativity, is now smeared out near the Planck scale. Proper time s can be extended indefinitely (s→∞) so that intrinsic metric fluctuations can restore geodesic completeness although the geodesics remain trapped for all time: although a singularity can be removed the collapsing matter still creates a black hole. A Fokker—Planck formulation also gives zero probability that θ→−∞ for s→∞. Essentially, the short distance stochastic corrections to the deterministic equations of general relativity can remove pathologies such as singularities, conjugate points and geodesic incompleteness.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    General relativity and gravitation 32 (2000), S. 1583-1614 
    ISSN: 1572-9532
    Keywords: Inflation ; axion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A simple, consistent inflationary cosmology is developed from the basic structure of the Σ-model expansion in string theory, which corresponds to the low energy effective (α′ → 0) limit. The classical dilaton background solution φ is subject to stochastic vacuum fluctuations near the Planck scale. The motivation here is that the coupling of stochastic noise to a classical field theory often provides workable and powerful methodologies with which to explore quantum behaviour, turbulence and pattern and structure formation. The dilaton fluctuations induce random (Weyl) conformal fluctuations in the Einstein frame metric. The additional vacuum stress-energy tensor—which the fluctuations induce within the string derived Einstein-dilaton field equations—can be interpreted and described in terms of a "turbulent perfect fluid" with a fluctuating negative pressure. A (stochastic) de-Sitter solution describes a turbulent, inflating vacuum bubble whose exponential expansion is future-eternal and unbounded; but the vacuum turbulence breaks the spherical symmetry and homogeneity usually associated with a smooth de-Sitter solution. Consequently, the strong energy condition (SEC) is violated for the turbulent perfect fluid tensor describing the (false) vacuum—this suggests that there is no initial singularity. With a suitable "rollover" dilaton potential V(φ) there can then be a phase transition to a hot Friedmann expanding universe at the minima of the potential as φ → φo. Assuming an instantaneous decay of the inflaton to a perfect fluid of thermal radiation, the de-Sitter and Friedman solutions are matched using a step function. However, the residual vacuum turbulence carried over from inflation, breaks the usual homogeneity and symmetry of the FRW solutions. The induced cosmological constant plays a role somewhat like a Reynold's number for a non-linear, turbulent fluid. The SEC—and therefore the Hawking singularity theorem—is obeyed only after inflation, so it appears that the universe is singular only within the perspective of a matter or radiation fluid dominated era; but past directed matter worldlines do not converge in the past since they cannot be extrapolated beyond the (phase) transition at which the turbulent vacuum bubble decayed. On cosmic time scales, the vacuum "turbulence" augments both cosmic acceleration (the Hubble parameter) and distances with respect to the standard, classical Friedman RW cosmologies.
    Type of Medium: Electronic Resource
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