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  • 1
    Electronic Resource
    Electronic Resource
    009 
Calcium-Zinc Alginate and Recombinant Human bFGF; Its efficacy from the histological standpoint (2004)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 12 (2004), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To evaluate the efficacy of wound dressing material, Calcium-Zinc Alginate: Curasorb Zn® as a carrier of the recombinant human bFGF, histological detection was performed. Methods: Full thickness skin defect on the back of Wistar rat was made for four groups; the control group, bFGF group; topical application of recombinant human bFGF for 5 μg per day, Ca-Zn Alginate group; topical use of the dressing and the group that both the bFGF and Ca-Zn Alginate were applied, nine rats for respective group. Results: Significant granulation was noted both bFGF group and Ca-Zn Alginate group compared to the control group. Fibrosis was noted in the control and Ca-Zn Alginate group whereas no fibrosis was noted in the FGF group. Numerous amounts of cells were noted in the FGF group which indicate strong inflammation. Also, marked abscess formation was noted in the bFGF group. The greatest thickness of granulation was obtained in the group that both the bFGF and Ca-Zn Alginate were applied. Conclusions: It was considered that the appropriate use of the carrier for the bFGF is important to control infection. The Ca-Zn Alginate dressing was effective to suppress abscess formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2004.abstractab.x
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  • 2
    Electronic Resource
    Electronic Resource
    Shell model results for exotic nuclei (2003)
    Springer
    The European physical journal 20 (2003), S. 69-73 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Recent developments of the nuclear shell model are presented. The magic numbers are the key concept of the shell model, and are shown to be different in exotic nuclei from those of stable nuclei. Their novel origin and robustness will be discussed. By the Monte Carlo Shell Model (MCSM), the structure of low-lying states can be studied with realistic interactions for a wide variety of nuclei. Some examples are discussed in connection to the triaxial deformation and a narrow shell gap at N = 20 for Z smaller.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/i2003-10201-5
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  • 3
    Electronic Resource
    Electronic Resource
    Synovial inflammation and hyperplasia induced by gliostatin/platelet-derived endothelial cell growth factor in rabbit knees (2000)
    Springer
    Rheumatology international 20 (2000), S. 13-19 
    Details
    ISSN: 1437-160X
    Keywords: Key words Gliostatin ; Thymidine phosphorylase ; Platelet-derived endothelial cell growth factor ; Rheumatoid arthritis ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neovascularization, proliferation of synovial cells, and mononuclear cell influx and activation are characteristic events observed in synovial joints in the pathohistology of rheumatoid arthritis (RA). The objective of this study was to examine synovial inflammation in rabbit knees induced by intra-articular administration of human gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF), which shares a high degree of chemical homology with thymidine phosphorylase (dThdPase) and is known to have angiogenic activity. Purified recombinant human gliostatin (rHuGLS) and its mutant protein, which was prepared by site-directed mutagenesis and which lacks dThdPase activity, were administered at various doses to rabbit knee joints. The effects of rHuGLS and the mutant were examined histologically. Intra-articular injection of rHuGLS resulted in the development of diffuse synovitis resembling RA. The mutant protein also brought about the same effect. These findings suggest that human GLS can cause RA-like synovitis in rabbit knee joints via a mechanism other than its dThdPase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960000067
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  • 4
    Electronic Resource
    Electronic Resource
    Factors correlated with emotional instability in SLE outpatients (2000)
    Springer
    Modern rheumatology 10 (2000), S. 31-37 
    Details
    ISSN: 1439-7609
    Keywords: Key words Systemic lupus erythematosus ; Emotional instability ; Social factors ; Medical factors ; Physical factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-four female outpatients with systemic lupus erythematosus (SLE) who are able to live on their own were investigated. We statistically analyzed the relationship between emotional instability based on psychological tests (Cornell Medical Index), and physical, medical, and social factors based on both our clinical records and original questionnaires. The emotional instability was related to not "working," an older "age at the time of SLE diagnosis," being "anxious about the adverse effects of steroids," or not "understanding the details of the disease and treatment at the time SLE treatment was started." No relationship with previously experienced physical factors was observed. In addition, no relationship with disease activity was observed either. We identified the characteristic correlation between emotional instability and medical and social factors in this study. Paying close attention to these factors may thus be useful in both preventing the appearance of psychological problems and developing effective early treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070036
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  • 5
    Electronic Resource
    Electronic Resource
    Behçet's disease associated with complement component 9 (C9) deficiency (2000)
    Springer
    Modern rheumatology 10 (2000), S. 276-278 
    Details
    ISSN: 1439-7609
    Keywords: Key words Behçet's disease ; Complement component 9 (C9) ; Complement deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Behçet's disease is a multisystem inflammatory disorder with unknown etiology. It has been shown that the titer of plasma complement component 9 (C9) is a good indicator of the disease activity. Therefore, the involvement of C9 in the pathogenesis of Behçet's disease has been suggested. We report a case of Behçet's disease associated with complete C9 deficiency (C9D) carrying the homozygous nonsense mutation at Arg-95 of C9 (R95X). The patient presented the typical characteristics of Behçet's disease, such as uveitis, recurrent oral aphthae and genital ulcers, and arthritis, suggesting that C9 does not play an essential role in the pathogenesis of Behçet's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070017
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    Paper (German National Licenses)
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