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  • 2000-2004  (7)
Source
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    The Immunological Hurdles to Cardiac Xenotransplantation (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 16 (2001), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The main hurdle to clinical application of cardiac xenotransplantation is the immune response of the recipient against the graft. Although all xenografts arouse an intense immune response, the effect of that response depends very much on whether the graft consists of isolated cells or an intact organ, such as the heart. Intact organs, which are transplanted by primary vascular anastomosis, are subject to severe vascular injury owing to the reaction of immune elements with the endothelial lining of donor blood vessels. Vascular injury leads to hyperacute rejection, acute vascular rejection, and chronic rejection. The immunological basis for these types of rejection and potential therapies, which might be used to avert them, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2001.tb00548.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The Pathology of Cardiac Xenografts (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 16 (2001), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pathology of cardiac xenografts has yielded critical insights into the mechanisms of xenograft rejection and the therapeutic procedures that might be applied to preventing or treating it. The conditions seen in rejecting cardiac xenografts include hyperacute rejection, acute vascular rejection, and cellular rejection. Hyperacute and acute vascular rejection of cardiac xenografts have features typical of humoral injury. Less is known about cellular rejection and only speculation can be offered about chronic rejection. Still, these features allow critical testing of pathogenetic mechanisms and therapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2001.tb00535.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 1227-1233 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Although over 50 years have passed since its first laboratory description, intentional induction of immune tolerance to foreign antigens has remained an elusive clinical goal. We previously reported that the requirement for ABO compatibility in heart transplantation is not applicable to infants. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1126
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Xeno—still stuck without αGal (2003)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 359-360 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor The development of pigs with targeted disruption of one α1–3galactosyltransferase (α1,3GT) allele and the spontaneous disruption of the other allele yielding galactose (Gal)-deficient pigs has encouraged the view that xenotransplantation may be close to clinical ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0403-359
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Knocking out xenograft rejection (2002)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 231-232 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Why transplant an animal organ or tissue into a person? The most obvious reason is that the use of animals as a source of organs and tissues would overcome the severe shortage of human organs and tissues that limits transplantation to about 5–10 % of those in need. But other, possibly more ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0302-231
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Xenotransplantation New risks, new gains (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 407 (2000), S. 27-30 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] No field of medicine has stimulated more excitement and controversy than xenotransplantation — the transplanting of animal organs and tissues into humans. The excitement stems from the possibility that transplantation could finally be extended to all patients who need it. The controversies ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35024181
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The fine cytokine line between graft acceptance and rejection (2000)
    [s.l.] : Nature America Inc.
    Nature medicine 6 (2000), S. 497-498 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Organs transplanted between genetically disparate individuals are subject to rejection by cell-mediated or humoral immune responses of the recipient. The cell-mediated immune response gives rise to cellular rejection; humoral immunity can cause three distinct types of rejection: hyperacute ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/74963
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    Paper (German National Licenses)
    Fulltext
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