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  • 1
    Electronic Resource
    Electronic Resource
    Accuracy of magnetic resonance imaging in determining cause of sudden death in adults: comparison with conventional autopsy (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 42 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim:  To determine the accuracy and define the limitations of post mortem magnetic resonance imaging (MRI) in determining the cause of sudden death in adults.Methods and results:  Sudden unexpected adult deaths in the community, reported to the Coroner (n = 10), excluding suspicious, violent or potentially drug-related deaths, were submitted to whole body MRI, followed by full invasive autopsy. The MRI scans were reported independently by four radiologists, blinded to the autopsy findings; two had previous experience of post mortem MRI. An abnormality that related to the cause of death as identified at autopsy, was identified by at least one radiologist in eight cases. These were pulmonary consolidation (autopsy finding pneumonia) (n = 1), pneumoperitoneum (autopsy finding perforated peptic ulcer) (n = 2), left ventricular failure (autopsy finding ischaemic heart disease) (n = 4), and disseminated bronchial carcinoma (n = 1). However, in only one case were all radiologists able to provide a confident cause of death (disseminated bronchial carcinoma). In two cases, in which death occurred 2–6 days and 3–6 days before MRI, early decomposition prevented interpretation of the images. Severe coronary artery atheroma was detected at autopsy in 7/10, but these lesions were not detected by MRI. Previous experience in reporting post mortem MRI, without autopsy comparison, did not result in more accurate interpretation of the images.Conclusions:  This pilot study suggests that post mortem MRI can identify some abnormalities relating to the common causes of sudden death in adults, but there is a need for greater experience in correlating MRI with autopsy findings before a reliable cause of death can be made by MRI alone. Inability to image coronary artery lesions, differentiating thrombus from clot and pulmonary oedema from pneumonic exudates, are specific problems that may be corrected with greater experience and higher resolution scans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01614.x
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  • 2
    Electronic Resource
    Electronic Resource
    Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas (2001)
    Oxford UK : Blackwell Science Ltd
    Histopathology 39 (2001), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas Aims: Tumour vascularity and vascular endothelial growth factor (VEGF) expression were studied in 41 primary brain tumours of astrocytic and oligodendroglial origin, in order to define the potential role of VEGF in the vascularization and growth of these tumours. Methods and results: Two commercial monoclonal antibodies to the VEGF protein (from R&D Systems and NeoMarkers), raised against different isoforms, were utilized. Each monoclonal antibody consistently detected the expression of VEGF in different cell types. The R&D Systems antibody only produced surface staining of endothelial cells in tumour capillaries, whereas staining with the Neomarkers antibody was largely confined to tumour cell cytoplasm. High levels of staining were seen with the R&D Systems and NeoMarkers antibodies in 13 and 14 of 15 glioblastomas, respectively, four and three of five oligodendrogliomas, four and seven of 10 anaplastic astrocytomas, one and three of six low-grade astrocytomas and none and none of five pilocytic astrocytomas. There was a close correlation between VEGF expression, tumour vascularity and grade. Conclusions: These findings support a role for VEGF in the angiogenesis of glioblastoma, anaplastic astrocytoma and oligodendroglioma. The distinct immunoreactivities of the two commercial monoclonal antibodies indicate either there is expression of different splice variants of VEGF or that the epitopes are differentially revealed during synthesis, secretion and receptor-binding of the growth factor. This highlights the importance of using more than one antibody in the evaluation of tissue VEGF expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2001.01230.x
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  • 3
    Electronic Resource
    Electronic Resource
    Assessment of patellar maltracking using combined static and dynamic MRI (2000)
    Springer
    European radiology 10 (2000), S. 1051-1055 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Biomechanics – Human – Knee joint – MR imaging – Cine – Patella range of Motion – Kinematics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Between January 1995 and Jul 1997, 474 patients with anterior knee pain resistant to conservative treatment were referred for MR of the knee. The MR examination consisted of routine sequences with an additional patellofemoral dynamic examination using a technique that has been developed at this institution. The dynamic study examines both knees simultaneously, with the patient supine and the quadriceps loaded. No gating or restraint apparatus is needed. Patellar subluxation or tilt was present in 188(40 %) of cases, bilateral in 104 and unilateral in 84 cases (right 39, left 45). It was classified as mild in 51 %, moderate in 39 % and severe in 10 %. Subluxation was more prevalent in females than males (42 % vs. 37 %) and this was most obvious in the severe group where 68 % were female. In 90 knees selected at random, four measurements of patellofemoral morphology were obtained using reconstructed images from a volume gradient echo sequence. These measurements were correlated with the degree of subluxation or tilt. A tibial tubercle distance greater than 20 mm, a femoral sulcus angle greater than 150 degrees, sulcus depth less than 4 mm were specific for subluxation but no measurement proved to be sufficiently sensitive to preclude a tracking study. MRI can be used to define more precisely the anatomy of the extensor mechanism and its relationship to the femur and tibia, in both a static and dynamic setting. In this way, patients with anterior knee pain can be classified more accurately and the outcomes of treatment more reliably assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300000358
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  • 4
    Electronic Resource
    Electronic Resource
    Confidential Incident Reporting on the UK Railways: The ‘CIRAS’ System (2000)
    Springer
    Cognition, technology & work 2 (2000), S. 117-125 
    Details
    ISSN: 1435-5566
    Keywords: Key words: Confidential reporting – Human factors – Railways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract: The paper describes CIRAS (Confidential Incident Reporting and Analysis System), a confidential reporting system developed by the authors in collaboration with ScotRail, the Health and Safety Executive, Railtrack and the (now defunct) British Rail Board. After a two-year pilot/developmental study with ScotRail during 1995–97, the system is now subscribed to by all but one of the major train operating companies, rail infrastructure and maintenance companies with a presence in Scotland; plus a developing profile in the rest of the UK.  CIRAS gathers data in three ways: (i) from an initial report form or telephone call, (ii) from a structured follow-up telephone questionnaire, and (iii) from an in-depth interview with a researcher (telephone or face-to-face, according to priority). The interviews bring to light details of personal motive, and of intended/unintended actions, which are not commonly found on company-run databases because of their association with disciplinary procedures. Information is processed through a human factors model and fed back to the companies involved, in disidentified form, to take corrective action.  The basic structure of the human-factors model is described; data are presented on reports received to date which have been processed through this model. The system has recently been recommended by a UK Parliamentary Committee and by Railtrack Safety and Standards Directorate for extension to the UK network as a whole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00011494
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