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  • 1
    Electronic Resource
    Electronic Resource
    Recruitment channel use and applicant arrival: An empirical analysis (2000)
    Springer
    Empirical economics 25 (2000), S. 673-697 
    Details
    ISSN: 1435-8921
    Keywords: Key words: recruitment ; labour demand ; JEL classification: J63
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract. This paper focuses on the recruitment behaviour of firms at the extensive margin; we empirically explore the relationship between employer search strategies and the number of applicants by means of (reduced form) two-equations simultaneous models. The empirical analysis is carried out on a rich micro data set on Dutch employer recruitment behaviour. Our empirical analysis reveals that the economic conditions prevailing on the labour market influence employer search activity at the extensive margin. In particular, we see that in tight (slack) labour markets characterised by excess demand (supply) of labour, the flow of applicants is smaller (larger). Employers react to the shortage (excess) of applicants by using more (less) often advertisements. This recruitment channel appears to trigger a significantly larger flow of applicants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001810000042
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Search Channel Use and Firms' Recruitment Behaviour (2000)
    Springer
    De economist 148 (2000), S. 373-393 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract In the present paper we examine the impact of firms' attitudes towards key aspects of the recruitment process on the number of search channels activated. Furthermore, we address the issue of the timing of the activation of additional search channels. It is found that firms that attach importance to search effort and to applicants' motivation generally use more search channels than firms that do not attach any importance to the aforementioned aspects of recruitment. Furthermore, it appears that employers generally use fewer search channels for permanent positions. However, firms with a personnel department which are hiring for a vacancy requiring specific work experience usually activate multiple search channels. Finally, the choice of advertising as the first search channel appears to negatively affect the chances of considering additional channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004046320967
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Development of a new vaccine formulation that enhances the immunogenicity of tumor-associated antigen CaMBr1 (2000)
    Springer
    Cancer immunology immunotherapy 49 (2000), S. 296-304 
    Details
    ISSN: 1432-0851
    Keywords: Key words Tumor-associated-antigen ; Immunogenicity ; Vaccine formulation ; Glycoconjugates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aberrant glycosylation is one of the most constant traits of malignant cells. The CaMBr1 hexasaccharide antigen, originally defined on the human breast carcinoma cell line MCF7, is expressed on some normal tissues but overexpressed in a high percentage of human breast, ovary, prostate and lung carcinomas. CaMBr1 overexpression is associated with poor prognosis. The epitope consists of the tetrasaccharide Fuc(α1-2)Gal(β1-3)GalNAc(β1-3)Galα-O-spacer, which has recently become available as a synthetic oligosaccharide. Here we report the CaMBr1 tetrasaccharide conjugation to two different carrier proteins (CRM197 and KLH) and the evaluation of conjugate immunogenicity in mice following their administration in various vaccine formulations with two adjuvants (MPL-SE and Detox-PC). Radioimmunoassay to determine the level and isotype of anti-tetrasaccharide antibodies in mouse sera, and cytofluorimetric analysis and 51Cr-release assay on human tumor cells, to evaluate specificity of binding and complement-dependent lysis respectively, identified CaMBr1-CRM197, in association with the MPL-SE adjuvant, as the best vaccine formulation. This combination induced (1) production of tetrasaccharide-specific antibodies, with negligible side-effects; (2) antibodies with complement-mediated cytotoxic activity on human CaMBr1-positive cells and (3) a high titer of IgG1 detected in sera obtained 3 months after the first injection, indicating that the anti-tetrasaccharide antibody response was mediated by T cell activation. The availability of CaMBr1-glycoconjugate in the minimal and functional antigenic structure and the identification of an efficacious vaccine formulation opens the way to exploring the activity of this glycoconjugate in a clinical setting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620000113
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    Paper (German National Licenses)
    Fulltext
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