ISSN:
1573-1111
Keywords:
naproxen
;
cyclodextrins
;
complexation
;
association constants
;
fluorescence
;
NMR
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Inclusion complexation processesinvolving four cyclodextrins and naproxen have beenstudied for the protonated and unprotonated forms ofthe guest molecule. The association constants havebeen evaluated from changes in the fluorescenceintensity of naproxen following addition of acyclodextrin to an aqueous naproxen solution. 1HNMR NOESY and ROESY spectra have shown that twoorientations of the guest molecule relative toβ-cyclodextrin are possible.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008114815223
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