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  • 1
    Electronic Resource
    Electronic Resource
    Female Gender is a Risk Factor for Drug-Induced Long QT and Cardiac Arrhythmias in an In Vivo Rabbit Model (2001)
    Oxford, UK : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 12 (2001), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Gender Differences in Drug-Induced LQT and TdP. Introduction: Clinical observations and in vitro experimental data indicate that females have a longer QT interval than males, which is associated with a higher risk of drug-induced cardiac arrhythmias. Little is known about this gender difference in anesthetized animals, which may affect the outcome of in vivo drug tests. Methods and Results: We evaluated potential gender differences in ventricular repolarization (QT, QTc, JT, and JTc interval) and its dispersion, as well as in its response to dofetilide, an IKr blocker, in anesthetized rabbits challenged with the α1-adrenoceptor agonist methoxamine. A 12-lead ECG was recorded during the experiments. At baseline, there were no significant gender differences in ventricular repolarization values in male and female rabbits under anesthesia. Dofetilide (0.04 mg/kg/min IV for 60 min; n = 10 per gender) produced marked prolongation of the ventricular repolarization time and its dispersion, associated with a high incidence of polymorphic ventricular tachycardia (PVT; 100% in females vs 80% in males) and ventricular fibrillation (VF; 80% in females vs 50% in males; P 〉 0.05). QT and JT interval at 2 minutes as well as QT and JT dispersion at 10 and 30 minutes during dofetilide infusion were significantly higher in female than in male rabbits. After 30 minutes of dofetilide infusion, 10 of 10 female rabbits had severe cardiac arrhythmias (complete AV block, PVT, or VF), so ECG parameters were impossible to assess (vs 3/10 males with severe cardiac arrhythmias; P 〈 0.05). During dofetilide infusion, female rabbits developed complete AV block, PVT, or VF at doses about 50% lower than those given to males. Conclusion: The present study indicates that female rabbits are more susceptible to drug-induced long QT and cardiac arrhythmias than are male rabbits; therefore, female rabbits are more appropriate for testing drug-induced cardiac arrhythmias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2001.00538.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanisms of Sympathetic Neural Regeneration After Myocardial Infarction: (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 11 (2000), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2000.01352.x
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  • 3
    Electronic Resource
    Electronic Resource
    Heart Rate Variability: (2003)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 14 (2003), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2003.03258.x
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  • 4
    Electronic Resource
    Electronic Resource
    Confirmatory Factor Analysis of the End-User Computing Satisfaction Instrument: Replication within an ERP Domain (2003)
    350 Main Street , Malden , MA 02148 , USA . : Decision Sciences
    Decision sciences 34 (2003), S. 0 
    Details
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Over the past decade, organizations have made significant investments in enterprise resource planning (ERP) systems. The realization of benefits from these investments depends on supporting effective use of information technology (IT) and satisfying IT users. User satisfaction with information systems is one of the most important determinants of the success of those systems. Drawing upon a sample of 407 end users of ERP systems and working within the framework of confirmatory factor analysis (CFA), this study examines the structure and dimensionality, and reliability and validity of the end-user computing satisfaction (EUCS) instrument posited by Doll and Torkzadeh (1988). In response to Klenke's (1992) motion to cross-validate management information system (MIS) instruments and to retest the end user computing satisfaction instrument using new data, this study's results, consistent with previous findings, confirm that the EUCS instrument maintains its psychometric stability when applied to users of enterprise resource planning application software. Implications of these results for practice and research are provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-5414.2003.02428.x
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  • 5
    Electronic Resource
    Electronic Resource
    Random amplified polymorphic DNA variation within and among meadow bromegrass progeny types (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 122 (2003), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Ten meadow bromegrass genotypes tested as half-sib (polycross, PX; open-pollinated, OP) and selfed (S1) progenies were surveyed using random amplified polymorphic DNA. Fourteen primers, which produced 32 markers, were selected to determine the genotypes of 360 individuals from the three progeny tests. Analysis of molecular variance was performed in each progeny test, and genetic distances between genotypes and progeny types were determined. Among genotype genetic variation in half-sib (PX and OP) progenies was similar. Genetic variation among genotypes for S1 progenies (30.5%) was about twice that found in the half-sib progenies. Variation between individual S1 progenies ranged from 15.7% to 50.1%, while in the half-sib progenies, the range was 6.9-24.1%. Based on average distances between progeny types for a given genotype, OP and PX were closer to each other than to the S1. An analysis of variance of the molecular marker frequency occurrence was performed for 12 plants within each progeny type of each genotype. Marker frequencies, expressed in percentages, ranged from 10.7% to 84.3%. No significant differences were found for genotype and progeny type-genotype interaction suggesting that all genotypes behave in a similar manner across the different progeny types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2003.00830.x
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  • 6
    Electronic Resource
    Electronic Resource
    Estimating the genetic relationship of hybrid bromegrass to smooth bromegrass and meadow bromegrass using RAPD markers (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 120 (2001), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The two most widely grown bromegrass species in North America are smooth bromegrass, a hay type grass, and meadow bromegrass, a pasture type grass. Hybrid populations between these two species have been developed through hybridization and recurrent selection. The objective of this study was to determine the genetic relatedness of the hybrid bromegrass population S-9073M to its parental populations using random amplified polymorphic DNA (RAPD) markers and to determine genetic variation within and between populations. Individuals from each of the three populations were genotyped at 43 polymorphic RAPD loci. One of the RAPD fragments was meadow bromegrass-specific. Cluster analysis showed three groups representing the two parental populations and the hybrid population. An analysis of molecular variance (AMOVA), showed that the hybrid population had the highest within-population variation, followed by meadow bromegrass and smooth bromegrass. The interpopulation genetic distance (phi-statistic =Φst) was highest between meadow and smooth bromegrass and lowest between smooth and hybrid bromegrass. The hybrid population was genetically intermediate to smooth bromegrass and meadow bromegrass, but closer to smooth bromegrass, possibly reflecting the selection criteria used in the development of this hybrid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2001.00555.x
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  • 7
    Electronic Resource
    Electronic Resource
    Analgesic requirements in morbidly obese patients (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03766.x
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  • 8
    Electronic Resource
    Electronic Resource
    Cold Plasma Synthesis of Poly(ethylene glycol)-like Layers on Stainless-Steel Surfaces to Reduce Attachment and Biofilm Formation by Listeria monocytogenes (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Poly(ethylene glycol) (PEG)-like structures were generated on stainless steel under di(ethylene glycol) vinyl ether (DiEGVE) radio frequency-plasma environments. Electron spectroscopy for chemical analysis and attenuated total reflectance Fourier transform infrared spectroscopy indicated a PEG-like deposition, which was stable to cleaning, sanitizing, and storage for up to 2 mo. Atomic force microscopy and water contact angle analysis indicated that the modified stainless-steel surfaces were less rough and more hydrophilic than the unmodified surfaces. Listeria monocytogenes attachment and biofilm formation on modified surfaces decreased more than 90% compared with the unmodified stainless steel (P 〈 0.01). DiEGVE cold plasma was demonstrated to be a promising technique to reduce bacterial contamination on surfaces encountered in food-processing environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2003.tb05803.x
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  • 9
    Electronic Resource
    Electronic Resource
    Finding bibliographic information about books on the WWW: an evaluation of available sources (2004)
    Bradford : Emerald
    Online information review 28 (2004), S. 33-42 
    Details
    ISSN: 1468-4527
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Information Science and Librarianship
    Notes: The World Wide Web offers different systems to retrieve information about published books in the form of online catalogues of libraries and popular online bookstores, and subscription-based bibliographic databases. The paper determines the usefulness of bibliographic information offered by such systems. For the quantitative evaluation, random tests with titles of known books were executed. The quality of the resulting output was evaluated on the basis of a set of criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/14684520410522439
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  • 10
    Electronic Resource
    Electronic Resource
    Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 1084-1089 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In T-cell acute lymphoblastic leukemia (T-ALL), transcription factors are known to be deregulated by chromosomal translocations, but mutations in protein tyrosine kinases have only rarely been identified. Here we describe the extrachromosomal (episomal) amplification of ABL1 in 5 of 90 (5.6%) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1425
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