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  • 1
    Electronic Resource
    Electronic Resource
    Ligand selectivity and competition between enzymes in silico (2004)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1039-1045 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In a cell, there are many possibilities for cross interactions between enzymes and small molecules, arising from the similarities in the structures of the metabolites and the flexibility in binding of protein active sites. Despite this promiscuity, the cognate partners must be able to recognize ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt999
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    From structure to function: Approaches and limitations (2000)
    [s.l.] : Nature America Inc.
    Nature structural biology 7 (2000), S. 991-994 
    Details
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/80784
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of functional annotation schemes for genomes (2000)
    Springer
    Functional & integrative genomics 1 (2000), S. 56-69 
    Details
    ISSN: 1438-7948
    Keywords: Functional genomics Protein function Gene product classification Ontology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. In this paper we survey a number of functional classification schemes applicable to genomes. We present the concepts of depth, breadth and resolution as descriptors of the schemes' scope and architecture and compare selected classifications according to these criteria. We also generate a 'Combined Scheme' against which we map six classifications which we believe are representative of the range currently available. The mapping allows the generation of 'FuncWheels', which are graphical representations of hierarchical classification schemes. They are used to illustrate similarities and differences in functional space coverage. This survey highlights many issues related to the design and implementation of gene product functional classifications, which are discussed in the light of emerging 'second-generation' schemes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101420000005
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    Paper (German National Licenses)
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