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An ab initio study of spectroscopy and predissociation of ClO (2000)

Toniolo, A.

College Park, Md. : American Institute of Physics (AIP)

The Journal of Chemical Physics 112 (2000), S. 2790-2797

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ISSN: 1089-7690

Source: AIP Digital Archive

Topics: Physics , Chemistry and Pharmacology

Notes: We have computed all the electronic states of ClO arising from the Cl(2P)+O(3P) dissociation limit and several of those connected with Cl(2P)+O(1D). Only two excited states have attractive potentials, A 2Π and 1 4Σ−. The A 2Π state undergoes a well known predissociation, because several as yet unknown potential curves cross the A 2Π one and are coupled to it by nonadiabatic and/or spin-orbit interactions. The calculation of the interaction matrix elements allows to explain the predissociation of A 2Π, due to transitions to the 3 2Π, 12Δ, 2 4Σ− and other less important states, all leading to the Cl(2P)+O(3P) dissociation. © 2000 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.480853

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DNA Immunization of Mice against the VP1 Capsid Protein of Coxsackievirus B4 (2002)

Toniolo, A. ; Falcone, V. ; Bernasconi, C. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Scandinavian journal of immunology 56 (2002), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The protective activity of a DNA plasmid encoding the immunodominant capsid protein VP1 of coxsackievirus B4 (CBV-4) was studied in BALB/c mice. The plasmid pCI-B4-1-c – which gave the highest expression level of VP1 in cultured monkey and human cells – was chosen for immunization. Two injections of pCI-B4-1-c (1 month apart) into the regenerating mouse muscle tissue induced a specific antibody response to CBV-4, as shown by immunoenzyme and neutralization assays. Upon challenge with live CBV-4, the mortality rate of mice vaccinated with the recombinant plasmid was significantly reduced (21% versus 〉58%) as compared with that of mice that had been either nontreated or injected with a control plasmid devoid of the insert. The VP1-based vaccine, however, did not provide complete protection as – after virus challenge – moderate viraemia occurred together with modest plasma elevations of pathogenesis-related enzymes (amylase and creatine kinase). Yet, immunofluorescence of the small intestine and heart did confirm the protective effect of the VP1-encoding vaccine. In order to obtain a more complete protection against CBV-4, it may be beneficial to immunize mice with combinations of separate DNA plasmids encoding not only VP1 but also the VP2 and VP3 capsid proteins.