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  • 2000-2004  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Cardiovascular Actions of Berberine (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 19 (2001), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Berberine, is an alkaloid from Hydrastis canadensis L., Chinese herb Huanglian, and many other plants. It is widely used in traditional Chinese medicine as an antimicrobial in the treatment of dysentery and infectious diarrhea. This manuscript describes cardiovascular effects of berberine and its derivatives, tetrahydroberberine and 8-oxoberberine. Berberine has positive inotropic, negative chronotropic, antiarrhythmic, and vasodilator properties. Both derivatives of berberine have antiarrhythmic activity. Some of cardiovascular effects of berberine and its derivatives are attributed to the blockade of K+ channels (delayed rectifier and KATP) and stimulation of Na+-Ca2+ exchanger. Berberine has been shown to prolong the duration of ventricular action potential. Its vasodilator activity has been attributed to multiple cellular mechanisms. The cardiovascular effects of berberine suggest its possible clinical usefulness in the treatment of arrhythmias and/or heart failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.2001.tb00068.x
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  • 2
    Electronic Resource
    Electronic Resource
    Innate immune responses of a lepidopteran insect, Manduca sexta (2004)
    Oxford, UK; Malden , USA : Munksgaard International Publishers
    Immunological reviews 198 (2004), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary:  Many innate immune mechanisms are conserved throughout the animal kingdom. Manduca sexta, a widely used model for insect biochemical research, employs these mechanisms to defend against invading pathogens and parasites. We have isolated from M. sexta hemolymph a group of proteins (hemolin, peptidoglycan recognition proteins, β-1,3-glucan recognition proteins, and C-type lectins), which serve as a surveillance mechanism by binding to microbial surface molecules (e.g. peptidoglycan, lipopolysaccharide, lipoteichoic acid, and β-1,3-glucan). The binding triggers diverse responses such as phagocytosis, nodule formation, encapsulation, melanization, and synthesis of anti-microbial peptides/proteins. Some of these responses are mediated and coordinated by serine proteinase cascades, analogous to the complement system in mammals. Our current research is focused on the proteolytic activation of prophenoloxidase (proPO) – a reaction implicated in melanotic encapsulation, wound healing, and protein cross-linking. We have isolated three proPO-activating proteinases, each of which requires serine proteinase homologs as a cofactor for generating active phenoloxidase. The proteinases and proteinase-like molecules, containing one to two clip domains at their amino-terminus, are acute-phase proteins induced upon an immune challenge. Inhibitory regulation of the proteinases by serpins and association of the proteinase homologs with a bacteria-binding lectin are important for ensuring a localized defense response. Additional serine proteinases expressed in M. sexta hemocytes and fat body have been discovered. Future research efforts will be aimed at elucidating the proteinase cascade for proPO activation and investigating the roles of proteinases in other immune responses such as processing of plasmatocyte-spreading peptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-2896.2004.0121.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Microstructures and Microwave Dielectric Characteristics of CaRAlO4 (R = Nd, Sm, Y) Ceramics with Tetragonal K2NiF4 Structure (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Ceramic Society 87 (2004), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: CaRAlO4 (R = Nd, Sm, Y) ceramics with a K2NiF4 structure were prepared by a solid-state reaction approach, and their microwave dielectric characteristics were evaluated, along with their microstructures. Dense CaNdAlO4, CaSmAlO4, and CaYAlO4 ceramics were obtained by sintering at 1425°–1500°C in air for 3 h, and good microwave dielectric characteristics were achieved: (1) ɛ= 18.2, Qf= 17 980 GHz, τf=−52 ppm/°C for CaNdAlO4; (2) ɛ= 18.2, Qf= 51 060 GHz, τf=−3 ppm/°C for CaSmAlO4; and (3) ɛ= 18.9, Qf= 39 960 GHz, τf= 6 ppm/°C for CaYAlO4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.2004.tb06373.x
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    Paper (German National Licenses)
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