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  • 1
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The prevalence of asthma and allergic disease has increased in many countries. It has been proposed that vaccinations may contribute to the development of allergic disease by reducing clinical infections in infancy or through the direct IgE-inducing effects of the vaccines. Evidence for a potential role of immunizations in the development of allergic disease is scarce. Therefore the objective was to study the associations between vaccinations against measles, mumps and rubella (MMR), natural infections of these diseases and atopic sensitization to indoor and outdoor allergens and allergic symptoms in schoolchildren. The cross-sectional study including 1537 8th grade school children aged 13–15 years living in 10 communities across Switzerland was organized in the framework of an environmental health surveillance program within the School Health Services (Swiss Surveillance Program of Childhood Asthma and Allergies with respect to Air Pollution and Climate, SCARPOL). Main outcome measures were asthma and sneezing during pollen season assessed by parental questionnaires and atopic sensitization determined by IgE concentrations to various allergens. It was found that parents' reported history of measles or mumps was associated with a stronger immune response than two or more vaccinations against the respective infection (measles: geometric mean IgG titers (GMT) lU/ml (95% Cl) 2.8 (2.0–3.9) vs. 1.2 (1.0–1.4), mumps: GMT PE/ml (95% Cl) 16.3 (13.9–19.1) vs. 8.5 (6.1–11.7). With respect to atopic sensitization similar associations for exposure by natural MMR-infections or MMR-vaccinations were found: measles: OR (95% Cl) 1.02 (0.53–1.96) vs. 1.22 (0.69–2.16), mumps: 0.59 (0.38–0.93) vs. 0.79 (0.49–1.27), rubella: 0.93 (0.61–1.43) vs. 0.95 (0.66–1.37), respectively. Inverse relationships were found between the risk of asthma and a positive disease history or vaccination of measles 0.36 (0.14–0.91) vs. 0.45 (0.21–0.98) or a positive serum titer against measles 0.65 (0.35–1.20). From the present study can be concluded that exposure by MMR-vaccinations or natural MMR-infections in childhood does not increase the risk of sensitization to common allergens as well as to allergic respiratory diseases. MMR-vaccinations or natural MMR-infections are therefore an unlikely factor contributing to the increase in atopic disease in developed countries.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1436-6304
    Keywords: Schlüsselwörter: Clusteranalyse – Dynamische Fuzzy-Datenanalyse – Szenarioanalyse ; Key words: Cluster analysis – Dynamic fuzzy data analysis – Scenario analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Abstract. One goal of scenario analysis is to investigate possible future developments. In order to cover almost all alternatives it is desirable to analyze as many different scenarios as possible. On the other hand the complexity of the analysis grows as the number of scenarios increases. This often limits the number of scenarios considered. At this point dynamic fuzzy data analysis can be used. It offers methods to cluster objects (i.e. scenarios) which are represented by trajectories over time, therefore reducing complexity by extracting a small set of typical scenarios out of a large set of possible scenarios. Thereafter these typical scenarios can be interpreted by an expert. This paper describes such a dynamic fuzzy data analysis method and describes how it can be used in scenario analysis.
    Notes: Zusammenfassung. Ein Ziel der Szenarioanalyse ist die Vorwegnahme möglicher zukünftiger Entwicklungen. Hierbei möchte man einerseits viele Szenarien betrachten, um möglichst alle Alternativen für die Zukunft zu erfassen. Andererseits steigt mit der Anzahl betrachteter Szenarien auch die Komplexität der Analyse, insbesondere bei der Extraktion typischer Szenarien aus der Menge aller betrachteten Szenarien, so dass oft nur relativ wenige Szenarien untersucht werden. An dieser Stelle bietet die dynamische Fuzzy-Datenanalyse Hilfe. Sie ermöglicht die Clusterung von Objekten (hier: Szenarien), die durch (zeitliche) Trajektorien beschrieben sind. Durch diese Clusterung kann eine große Menge von Szenarien auf eine kleine Menge typischer Szenarien reduziert werden, welche dann zur weiteren Interpretation durch Experten zur Verfügung stehen. Dieser Artikel beschreibt ein solches dynamisches Fuzzy-Clusterverfahren, und zeigt, wie es in der Szenarioanalyse eingesetzt werden kann.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 16 (2000), S. 73-80 
    ISSN: 1434-6036
    Keywords: PACS. 61.43.Fs Glasses - 63.50.+x Vibrational states in disordered systems - 63.20.-e Phonons in crystal lattice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Low-frequency vibrations of glassy and crystalline orthoterphenyl are studied by means of neutron scattering. Phonon dispersions are measured along the main axes of a single crystal, and the corresponding longitudinal and transversal sound velocities are obtained. For glassy and polycrystalline samples, a density of vibrational states is determined and cross-checked against other dynamic observables. In the crystal, low-lying zone-boundary modes lead to an excess over the Debye density of states. In the glass, the boson peak is located at even lower frequencies. With increasing temperature, both glass and crystal show anharmonicity.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European child & adolescent psychiatry 9 (2000), S. 212-218 
    ISSN: 1435-165X
    Keywords: Key words Attention deficit hyperactivity disorder – hyperkinetic disorders, inattention – hyperactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective: To explore age-of-onset criterion for the diagnosis of attention–deficit hyperactivity disorder (ADHD) in a school sample of young Brazilian adolescents. Methods: 191 students aged 12 to 14 years were evaluated using DSM-IV ADHD criteria, measures of ADHD symptoms and global impairment. Results: Both adolescents with ADHD (n=30) and adolescents who fulfilled all DSM-IV ADHD criteria, except age of onset of impairment criterion (ADHD w/o age-of-onset, n=27) had significantly higher scores on Attention Problems, Delinquent and Aggressive Behavior scales of the Child Behavior Checklist (CBCL) and lower scores on the Child Global Assessment scale (CGAS) than non-ADHD adolescents (n=134). Adolescents with ADHD and youths with ADHD w/o age-of-onset did not differ significantly in any measure assessed. Conclusion: These results concur with recent literature proposing revision of the age-of-onset criterion for the diagnosis of ADHD.
    Type of Medium: Electronic Resource
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