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  • 1995-1999  (2)
  • 1990-1994  (6)
  • 1975-1979
  • 1950-1954  (3)
  • 1945-1949
  • Biochemistry and Biotechnology  (4)
  • Organic Chemistry  (3)
  • 27.80.+w  (2)
  • Acetylcholine  (2)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    First observation of a superdeformed nucleus produced in an α xn reaction channel (1994)
    Springer
    The European physical journal 349 (1994), S. 5-6 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Re ; 23.20.Lv ; 27.80.+w
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Recent data from the EUROGAM array have revealed the population of the yrast superdeformed (SD) band of192Hg in the α4n exit channel of the16O+184W reaction at 113 MeV beam energy. The nucleus assignment was made on the basis of the SD band transition energies, and the observation of characteristic X-rays and lowlying yrast γ-transition of192Hg in coincidence with the SD band γ-rays. Both the feeding and decay-out patterns of the observed SD band have been found similar to the ones previously measured in the (36S,4n) reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296325
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  • 2
    Electronic Resource
    Electronic Resource
    Naloxone modulates the behavioral effects of cholinergic agonists and antagonists (1991)
    Springer
    Psychopharmacology 105 (1991), S. 57-62 
    Details
    ISSN: 1432-2072
    Keywords: Memory ; Acetylcholine ; Opiates ; Tremors ; Locomotor activity ; Naloxone ; Scopolamine ; Physostigmine ; Morphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral glucose administration enhances memory in rodents and humans. Recent findings suggest that glucose may affect behavior, in part, by augmenting central cholinergic functions and by attenuating central opiate functions. The present experiments examined interactions between an opiate antagonist, naloxone, and cholinergic agents to determine whether the effects would parallel those found with glucose. Three behavioral measures were assessed: tremors, hyperactivity, and spontaneous alternation. Naloxone (1 mg/kg) significantly augmented tremors elicited by physostigmine (0.3 mg/kg). Naloxone (1 mg/kg) also attenuated increases in locomotor activity and impairments in spontaneous alternation performance elicited by scopolamine (1 and 3 mg/kg for activity and alternation measures, respectively). Thus, across three diverse measures, naloxone produced effects similar to those previously reported for glucose. These findings are consistent with the hypothesis that release of cholinergic activity from opiate inhibition may contribute to glucose effects on behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02316864
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Intracellular Ca2+ signals in human-derived pancreatic somatostatin-secreting cells (QGP-1N) (1994)
    Springer
    Pflügers Archiv 428 (1994), S. 275-282 
    Details
    ISSN: 1432-2013
    Keywords: Somatostatin ; Intracellular Ca2+ homeostasis ; Somatostatin-secreting cell ; Fura-2 ; Microfluorimetry ; [Ca2+]i ; QGP-1N cells ; Acetylcholine ; Thapsigargin ; Caffeine ; Ryanodine ; Islets of Langerhans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single-cell microfluorimetry techniques have been used to examine the effects of acetylcholine (0.1–100 μM) on the intracellular free calcium ion concentration ([Ca2+]i) in a human-derived pancreatic somatostatin-secreting cell line, QGP-1N. When applied to the bath solution, acetylcholine was found to evoke a marked and rapid increase in [Ca2+]i at all concentrations tested. These responses were either sustained, or associated with the generation of complex patterns of [Ca2+]i transients. Overall, the pattern of response was concentration related. In general, 0.1–10 μM acetylcholine initiated a series of repetitive oscillations in cytoplasmic Ca2+, whilst at higher concentrations the responses consisted of a rapid rise in [Ca2+]i followed by a smaller more sustained increase. Without external Ca2+, 100 μM acetylcholine caused only a transient rise in [Ca2+]i, whereas lower concentrations of the agonist were able to initiate, but not maintain, [Ca2+]i oscillations. Acetylcholine-evoked Ca2+ signals were abolished by atropine (1–10 μM), verapamil (100 μM) and caffeine (20 mM). Nifedipine failed to have any significant effect upon agonist-evoked increases in [Ca2+]i, whilst 50 mM KCl, used to depolarise the cell membrane, only elicited a transient increase in [Ca2+]i. Ryanodine (50–500 nM) and caffeine (1–20 mM) did not increase basal Ca2+ levels, but the Ca2+-ATPase inhibitors 2,5-di(tert-butyl)-hydroquinone (TBQ) and thapsigargin both elevated [Ca2+]i levels. These data demonstrate for the first time cytosolic Ca2+ signals in single isolated somatostatin-secreting cells of the pancreas. We have demonstrated that acetylcholine will evoke both Ca2+ influx and Ca2+ mobilisation, and we have partially addressed the subcellular mechanism responsible for these events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00724507
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  • 4
    Electronic Resource
    Electronic Resource
    Two proton high-spin excitations and dipole bands in192Hg (1994)
    Springer
    The European physical journal 348 (1994), S. 87-93 
    Details
    ISSN: 1434-601X
    Keywords: 27.80.+w ; 21.10.Hw ; 21.60.Ev
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The192Hg nucleus was populated in the160Gd(36S, 4n) reaction at a beam energy of E=159 MeV. Emittedγ-rays were detected with the EUROGAM array comprising 43 Compton-suppressed large volume Ge detectors. The level scheme of192Hg has been extended up to an excitation energy of E=10.4 MeV and spin I=34 ħ. Two new structures, made of competing ΔI=1 and ΔI=2 transitions have been observed and their connexions with the low-lying levels established. Their lowest levels are located at 6.304 MeV and 6.879 MeV excitation energy. The experimental results are compared with mean-field HF+BCS calculations. It is proposed that the new structures originate from deformation-aligned quasi-proton excitations π(i13/2 * h9/2)K=11 andπ (h9/2) K=8 2 , coupled to rotation-aligned quasi-neutron ν(i13/2)n and quasi-proton π(h11/2)2 excitations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01289594
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The building of protein structures form α-carbon coordinates (1990)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 7 (1990), S. 366-377 
    Details
    ISSN: 0887-3585
    Keywords: computer modeling ; protein ; structure ; α-carbons ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A procedure for the construction of complete protein structures from only αcarbon coordinates is described. This involves building the backbone by sequential addition of Pro, Gly, or Ala residues. This main chain structure is then refined using molecular dynamics. Side chains are constructed by sequential addition of atoms with intermediate molecular dynamics refinement. For α lytic protease (a structure that is mostly β sheet) a backbone root mean square deviation (RMSD) of 0.19 Å and an overall RMSD of 1.24 Å from the crystallographic coordinates are attained. For troponin C (67% β-helix), where the coordinates are available only for the α-carbons, a backbone RMSD of 0.41 Å and an overall RMSD of 1.68 Å are attained (fits kindly provided by Dr. Michael James and Natalie Strynadka). For flavodoxin a backbone RMSD of 0.49 Å and an overall RMSD of 1.64 Å were attained.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340070408
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  • 6
    Electronic Resource
    Electronic Resource
    A simple two-dimensional representation for the common secondary structural elements of polypeptides and proteins (1997)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 27 (1997), S. 227-233 
    Details
    ISSN: 0887-3585
    Keywords: peptide conformation ; ramachandran plot ; PDB search ; peptide dynamics ; BPTI ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A simple method is presented for projecting the conformation of extended secondary structure elements of peptides and proteins that extend over four Cαatoms onto a simple two-dimensional surface. A new set of two degrees of freedom is defined, a pseudo-dihedral involving four sequential Cαatoms, as well as the triple scalar product for the vectors describing the orientation of the three intervening peptide groups. The method provides a reduction in dimensionality, from the usual combination of multiple φ,ψ pairs to a single pair, yielding valuable information concerning the structure and dynamics of these important elements. The new two-dimensional surface is explored by reference to 63 selected protein crystal structures together with a comparison of model built peptides representing the common secondary structural elements. Dynamical aspects on this new surface are examined using a molecular dynamics trajectory of Basic Pancreatic Trypsin Inhibitor. © 1997 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 7
    Electronic Resource
    Electronic Resource
    Cultivation of attenuated hepatitis A virus antigen in a titanium static mixer reactor (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 44 (1994), S. 1315-1324 
    Details
    ISSN: 0006-3592
    Keywords: static mixer ; MRC-5 ; anchorage dependent ; hepatitis A ; animal cell culture ; bioreactor ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The titanium static mixer reactor, demonstrated for a variety of vaccine processes during the late 197s, was investigated for the production of attenuated hepatitis A virus antigen from anchorage-dependent MRC-5 cells. This reactor system used Charles River Biotechnological Services cabinets for monitoring and process control. Cell inoculation protocols, using 6000-10,000 cells/cm2, resulted on over 95% attachment at both the laboratory and pilot scales. Indirect monitoring techniques using oxygen, glucose, L-serine, and L-glutamine uptake rates were indicative of cell growth prior to virus inoculation as well as environmental and/or nutrient limitations. Seven laboratory-scale (3900 cm2) runs and one pilotscale (265,000 cm2) run were conducted to investigate refeeding regiments, parallel versus perpendicular element orientation, increased element surface area per unit volume, and scale-up performance. In general, lysate antigen yields achieved were similar to those of parallel T-flasks cultivated under similar conditions. © 1994 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260441107
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Purification of a pyrogen-free human growth hormone antagonist (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 48 (1995), S. 520-528 
    Details
    ISSN: 0006-3592
    Keywords: human growth hormone ; animal cell culture ; purification ; serum ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Human growth hormone (hGH) is a polypeptide with 191 amino acids and a molecular mass of 22 kilodaltons. With the aid of computer molecular simulation, an hGH analog was created by altering an hGH gene to reflect the change of one amino acid (glycine [G] 120 to arginine [R]) within the third α-helix of the hGH molecule. This hGH analog, named hGHG120R, was found to be an hGH antagonist. It may have important implications in treating human conditions in which hGH levels are abnormally high, as found in type I diabetics. Several hundred milligrams of purified hGHG120R were needed to determine the biological activity of the antagonist in animal models. A multistep downstream process was developed to purify hGHG120R from cultured mouse L cells transfected with the hGHG120R gene. The process consisted of cell clarification, salt precipitation, membrane ultrafiltration, reversed phase high performance liquid chromatography, phase separation, and lyophiliation. This work discusses the rationale for the design of the process and experimental results on the purification of hGHG120R using the process. © 1995 John Wiley & Sons, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260480515
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  • 9
    Electronic Resource
    Electronic Resource
    Étude analytique de l'acide quinaldique III. Étude d'un complexe interne de l'acide quinaldique: le quinaldate de fer (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 569-573 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This paper completes the preceding one by a colorimetric study of iron quinaldate. The dissociation constant of this compound has been determined by calculation based on colorimetric data.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350222
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  • 10
    Electronic Resource
    Electronic Resource
    Étude analytique de l'acide quinaldique I (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 396-400 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Etude pH-métrique de l'acide quinaldique. Détermination de la constante du couple acide/base (QH/Q-1), Ka = 1,2 · 10-5.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350150
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