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  • 1995-1999  (4)
  • 1990-1994  (2)
  • 1975-1979  (2)
  • 1930-1934
  • Engineering  (6)
  • Malondialdehyde
  • 1
    Electronic Resource
    Electronic Resource
    Influence of α-tocopherol over the time course of experimental IgA nephropathy (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 108-112 
    Details
    ISSN: 1432-198X
    Keywords: Key words Experimental IgA nephropathy ; Rats ; Malondialdehyde ; Transforming growth factor β1 mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study investigated the pathogenesis and the time course of kidney injury in experimental IgA nephropathy. In order to determine an appropriate period in the course of experimental IgA nephropathy to study renal injury and repair, we examined proteinuria and IgA deposition in the renal mesangium after 4, 8, and 16 weeks of mucosal challenge by bovine gamma globulins (BGG) provided in the drinking water. The hallmark of IgA deposition in the mesangium was present after 4 weeks and 8 weeks of BGG inoculation, but by 16 weeks, the mesangial IgA deposition had resolved. In addition, we confirmed our previous report on the beneficial effects of α-tocopherol in reducing proteinuria in IgA nephropathy at 8 weeks, and extended this observation to investigate the effects of dietary supplementation of α-tocopherol at both 4 weeks and 16 weeks. Proteinuria resolved spontaneously at 16 weeks. There is oxidative stress, as suggested by the elevation in plasma and renal malondialdehyde content, and increased fibrogenic cytokine message, as suggested by elevated transforming growth factor β1 mRNA. These increases were clearly blunted by α-tocopherol at both 4 weeks and 8 weeks. Treatment with α-tocopherol was associated with a significant reduction in the severity of proteinuria. Thus, our data suggest that the period between 4 and 8 weeks of BGG vaccination could be relevant in designing an appropriate model to study the molecular biology of the pathogenesis of renal injury and the effects of treatment. The 16-week model may be useful in exploring gene expression involved with spontaneous resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050573
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Vitamin E suppresses oxidative stress and glomerulosclerosis in rat remnant kidney (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 195-198 
    Details
    ISSN: 1432-198X
    Keywords: Key words Vitamin E ; 5/6 Nephrectomy rats ; Oxidative stress ; Malondialdehyde ; Transforming growth factor β ; Glomerulosclerotic index ; Remnant kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies have shown that reduction of renal mass in the rat remnant kidney model induces overproduction of transforming growth factor β1 (TGFβ1). We investigated whether an antioxidant, vitamin E, administered before the renal mass reduction, could prevent oxidative stress, reduce the overproduction of TGFβ1, and mitigate against the subsequent glomerulosclerosis. Our results revealed that the oxidative stress, as measured by the change in plasma malondialdehyde, is significantly reduced by prior vitamin E dietary supplementation. Finally, our data show that dietary vitamin E supplementation ameliorates the rise in TGFβ1 secondary to renal mass reduction and inhibits the glomerular sclerosis of the remnant kidney over the time course of this experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050591
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Substructured macro elements based on locally blended interpolation (1977)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 11 (1977), S. 1405-1421 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper we describe a new class of locally refined macro finite elements which are especially amenable to the use of substructuring techniques for the efficient solution of the resulting idealization. The tools and guidelines illustrated by the examples of modelling crack tips, point load singularities and singularities at re-entrant corners should enable an analyst to construct other such blended macro elements specifically tailored to his particular class of problems. The use of such substructured macro elements in finite element calculations permits substantial reduction in the manual effort of data preparation and the computational cost of numerical solution.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620110906
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Blended infinite elements for paraboblic boundary value problems (1978)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 12 (1978), S. 1841-1851 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A common method for numerically approximating two-point parabolic boundary value problems of the form ut = L[u]+f(u) defined of the semi-infinite strip S = [0, 1]×[0, ∞] is to first discretize the spatial operator in the differential equation and then solve for the time evolution. Such an approach typically involves solving a system of algebriaic equations at a sequence of time steps. In this paper we take a different approach and subdivide S into a collection of semi-infinite substrips Si = [xi, xi+1]×[0, ∞], and use blending function techniques to derive finite parameter functions ei(x, t) defined on Si. Spectral matching methods are used in deriving ei to ensure that (u - ei) can be made small on Si. Galerkin's method, with associated integration sover the entire space-time domain S, is then used to generate approximations to u(x, t) based upon the so defined infinite element (ei, Si). Approximations are hence found for all (x, t) in S by solving one well structed system of algebraic equations. We apply the method to several linear and non-linear problms.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620121206
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  • 5
    Electronic Resource
    Electronic Resource
    A fast solution method for three-dimensional many-particle problems of linear elasticity (1998)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 42 (1998), S. 1215-1229 
    Details
    ISSN: 0029-5981
    Keywords: boundary element method ; fast multipole method ; many-particle problem ; linear elasticity ; iterative solution strategy ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A boundary element method for solving three-dimensional linear elasticity problems that involve a large number of particles embedded in a binder is introduced. The proposed method relies on an iterative solution strategy in which matrix-vector multiplication is performed with the fast multipole method. As a result the method is capable of solving problems with N unknowns using only O(N) memory and O(N) operations. Results are given for problems with hundreds of particles in which N=O(105). © 1998 John Wiley & Sons, Ltd.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 6
    Electronic Resource
    Electronic Resource
    State-space representation and optimal control of non-linear material deformation using the finite element method (1993)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 36 (1993), S. 1967-1986 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A state-space model for representing the non-linear material deformation and an optimal control scheme for obtaining desired process conditions in the deforming material are presented in this paper. The formulation is general for various metal-forming processes including forging and extrusion operations. The state variables selected in the formulation are the die/billet contact nodal velocities and the nodal velocities of the critical finite elements of the billet. The control input is the ram velocity, which is determined by using the linear quadratic regulator (LQR) theory to maintain desired strain rates within the selected finite elements. The influence of an optimally designed ram velocity on the deforming material is studied using performance measures. This paper includes the development of the state-space model from non-linear finite element formulation, optimal control strategy and numerical example cases with discussions.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620361202
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Design of optimal process parameters for non-isothermal forging (1994)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 37 (1994), S. 155-177 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents a state space model and an optimal design scheme for non-isothermal metal forming processes. By selecting nodal velocity and temperature as the state variables, a non-isothermal state equation with coupled deformation and thermal terms is established. Based on this state space model, a control design scheme is developed to obtain the optimal die velocity and initial die temperature which will ensure that the effective strain-rate and temperature satisfy the design requirements. A titanium alloy engine disk forging is used to demonstrate two design examples. The results show that the proposed model and design scheme behave well for different design requirements.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620370111
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    p-ADAPTIVITY IN THE TIME DOMAIN USING MVpq MULTIVALUE TIME-MARCHING INTEGRATORS (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 2343-2367 
    Details
    ISSN: 0029-5981
    Keywords: transient ; time-marching ; single-step ; hierarchical ; p-adaptivity ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A unified set of MVpq multivalue algorithms for a single-step time-marching scheme is presented for the transient diffusion equation. These MVpq algorithms include the well-known SSij single-step algorithms as a special case. Non-uniform integrators are introduced in which discrete equations in the o.d.e. set each separately use a different order of integrator. Hierarchical variables are used in the time domain, firstly to facilitate non-uniform integrators and secondly to permit variable length timesteps. This paper is the first in a series. In the sequel (Part 2)17 error estimates are introduced and the non-uniform integrator concept is utilized to implement p-adaptivity in time. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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