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  • 1995-1999  (42)
  • 1990-1994  (55)
  • 1955-1959  (15)
  • 1905-1909  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Organochlorine Residues in Bats from Eckert James River Cave, Texas (1997)
    Springer
    Bulletin of environmental contamination and toxicology 58 (1997), S. 673 -680 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900386
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  • 2
    Electronic Resource
    Electronic Resource
    Organochlorine Pesticide Accumulation and Genotoxicity in Mexican Free-Tailed Bats from Oklahoma and New Mexico (1996)
    Springer
    Archives of environmental contamination and toxicology 30 (1996), S. 178-187 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The summer population of Mexican free-tailed bats (Tadarida brasiliensis) at Carlsbad Caverns, New Mexico, declined from an estimated 8.7 million in 1936 to 200,000 in 1974; thereafter, it increased to approximately 700,000 in 1991. This decline has been attributed primarily to organochlorine (OC) pesticide contamination and habitat disturbance. Similar declines have been observed in other populations of this species. This study examined the potential genotoxic effects of OC pesticide contamination on two populations of T. brasiliensis. Pesticide accumulation, frequencies of chromosomal aberrancy, and nuclear DNA content variation in spleen and testicular tissues were examined in specimens collected from Carlsbad Caverns and Vickery Cave, a maternity colony in northwestern Oklahoma, during the summers of 1990 and 1991. Pesticide residues in brain and carcass tissues were identified and quantified by electron capture gas chromatography. Genotoxicity was examined with the standard bone marrow chromosomal aberration assay and flow cytometry. Statistical relationships among pesticide content, observed chromosomal aberrancy, and nuclear DNA content variation were examined. Both populations demonstrated significant levels of DDE contamination; however, the Carlsbad Caverns population showed consistently higher pesticide loads. Males also demonstrated higher levels than females. No statistical differences in chromosomal aberrancy or nuclear DNA content variation were observed among sexes, sites, or collected periods. Positive correlations were detected between brain and carcass DDE concentrations for all bats examined. A significant negative relationship was found between brain DDE concentration and coefficients of variation in spleen DNA content only for males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215796
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  • 3
    Electronic Resource
    Electronic Resource
    Organochlorine pesticide accumulation and genotoxicity in Mexican free-tailed bats from Oklahoma and New Mexico (1996)
    Springer
    Archives of environmental contamination and toxicology 30 (1996), S. 178-187 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The summer population of Mexican free-tailed bats (Tadarida brasiliensis) at Carlsbad Caverns, New Mexico, declined from an estimated 8.7 million in 1936 to 200,000 in 1974; thereafter, it increased to approximately 700,000 in 1991. This decline has been attributed primarily to organochlorine (OC) pesticide contamination and habitat disturbance. Similar declines have been observed in other populations of this species. This study examined the potential genotoxic effects of OC pesticide contamination on two populations of T. brasiliensis. Pesticide accumulation, frequencies of chromosomal aberrancy, and nuclear DNA content variation in spleen and testicular tissues were examined in specimens collected from Carlsbad Caverns and Vickery Cave, a maternity colony in northwestern Oklahoma, during the summers of 1990 and 1991. Pesticide residues in brain and carcass tissues were identified and quantified by electron capture gas chromatography. Genotoxicity was examined with the standard bone marrow chromosomal aberration assay and flow cytometry. Statistical relationships among pesticide content, observed chromosomal aberrancy, and nuclear DNA content variation were examined. Both populations demonstrated significant levels of DDE contamination; however, the Carlsbad Caverns population showed consistently higher pesticide loads. Males also demonstrated higher levels than females. No statistical differences in chromosomal aberrancy or nuclear DNA content variation were observed among sexes, sites, or collected periods. Positive correlations were detected between brain and carcass DDE concentrations for all bats examined. A significant negative relationship was found between brain DDE concentration and coefficients of variation in spleen DNA content only for males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215796
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  • 4
    Electronic Resource
    Electronic Resource
    Protonated disilyne, Si2H+3: Molecular structures, vibrational frequencies, and infrared intensities (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 7230-7242 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The singlet potential energy surface of protonated disilyne, Si2H+3, has been investigated theoretically using the self-consistent field (SCF) and configuration interaction (CI) methods. Complete geometry optimizations and harmonic vibrational frequency analyses were performed using a double-ζ plus polarization (DZP) basis set at both the SCF and CI levels of theory. Five minima were located, with the global minimum being a highly symmetric tribridged structure. There are three minima clustered at 11–15 kcal/mol higher in energy. One of these has two bridging hydrogen bonds, another has only one and the third has none at all. A trans-bridged isomer is a higher-lying minimum. Structures corresponding to the classical and nonclassical forms of the vinyl cation, C2H+3, are shown not to be minima. Final energetic predictions are made using several extended basis sets which are at least triple-ζ plus double polarization (TZ2P) in quality. Inclusion of electron correlation is found to be very important for energetic comparisons, geometries and characterization of the stationary points. The theoretical infrared intensities may be useful in the spectroscopic identification of Si2H+3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.459446
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  • 5
    Electronic Resource
    Electronic Resource
    No Additional Value of Bismuth Subcitrate to Combination Omeprazole/Amoxicillin Therapy in the Eradication of Helicobacter pylori (1997)
    Cambridge, MA, USA : Blackwell Science, Inc.
    Helicobacter 2 (1997), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We investigated whether addition of bismuth subcitrate (BSC, 4 × 120 mg) to a two week therapy scheme of omeprazole (OME, 2 × 40 mg)/amoxicillin (AMO, 4 × 500 mg) increases Helicobacter pylori eradication.〈section xml:id="abs1-2"〉〈title type="main"〉Materials and Methods.Patients with dyspepsia underwent upper endoscopy. H. pylori positive patients were randomized to treatment A (OME/AMO, 83 patients) or treatment B (OME/AMO/BSC, 84 patients).〈section xml:id="abs1-3"〉〈title type="main"〉Results.In 65 patients of group A (78%) H. pylori was eradicated as determined from the histological assessment (Sydney classification) of antrum and corpus biopsies. In comparison, in 68 patients of group B (81%) H. pylori was eradicated (p = NS between groups). H. pylori eradication in both groups was associated similarly with a decrease of inflammation and activity whereas atrophy and intestinal metaplasia were not affected. A positive association was revealed between the decrease of H. pylori score and the decrease of both inflammation and activity scores for antrum as well as corpus biopsies.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions.Addition of BSC to OME/AMO does not increase H. pylori eradication in patients with dyspepsia. Eradication of H. pylori is associated with disappearance of epithelial damage (inflammation and activity) in antral and corpus mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1523-5378.1997.tb00087.x
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  • 6
    Electronic Resource
    Electronic Resource
    R 56865: A New Anti-Ischemic Principle (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 8 (1990), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.1990.tb00396.x
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacology of the Selective Phosphodiesterase III Inhibitor R 80122 (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 11 (1993), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.1993.tb00265.x
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  • 8
    Electronic Resource
    Electronic Resource
    Unsaturated Fatty Acids Esterified in 2-Acyl-1-Lysophosphatidylcholine Bound to Albumin Are More Efficiently Taken up by the Young Rat Brain than the Unesterified Form (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of the present study was to investigate whether unsaturated 2-acyl-lysophosphatidylcholine bound to plasma albumin is a relevant delivery form of unsaturated fatty acids to the developing brain. Twenty-day-old rats were perfused for 30 s with labeled palmitic, oleic, linoleic, and arachidonic acids in either their unesterified form or esterified in 2-acyl-lysophosphatidylcholine labeled on the choline and fatty acid moieties. Both forms were bound to albumin. Incorporation in brain lipid classes was followed within 1 h. The brain uptake of the unesterified fatty acids reached a plateau at 5–155 mim and was maximal for arachidonic acid (0.45% of the perfused dose). The brain uptake of palmitoyl-lysophosphatidylcholine was similar to that of palmitic acid, whereas that of other lysophosphatidylcholines increased with the degree of unsaturation (rate and maximal uptake) and was six- to 10-fold higher than that of the corresponding unesterified fatty acid. 2-Acyl-lysophosphatidylcholines were taken up without prior hydrolysis and reacylated into doubly labeled phosphatidylcholine, which was the most labeled lipid class, whereas lipid distribution of the unesterified fatty acid was more diversi fied. Partial hydrolysis of 2-acyl-lysophosphatidylcholine occurred in the brain tissue, and redistribution of the fatty acyl moiety into other phospholipid classes was also observed and was the highest for arachidonic acid. In this case, the percentage of esterification of this fatty acid in phosphatidylinositol (expressed as a percentage of the total lipid fraction) was relatively lower than that observed when the unesterified form was used. 1-Acyl-lysophosphatidylcholine (palmitoyl) was taken at the same extent that 2-acyllysophosphatidylcholine but was more hydrolyzed and reesterified in other lipid classes than 2-acyl isomer. All these results suggest that 2-acyl-lysophosphatidylcholine bound to albumin could be an efficient delivery form of unsaturated fatty acids to the developing rat brain and that the fatty acid delivery form could modulate their fate in the tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb08353.x
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  • 9
    Electronic Resource
    Electronic Resource
    Automatic External Defibrillators for Public Access Defibrillation: Recommendations for Specifying and Reporting Arrhythmia Analysis Algorithm Performance, Incorporating New Waveforms, and Enhancing Safety (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of noninvasive electrocardiology 2 (1997), S. 0 
    Details
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1542-474X.1997.tb00326.x
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  • 10
    Electronic Resource
    Electronic Resource
    Novel Effects of FCCP [Carbonyl Cyanide p-(Trifluoromethoxy)phenylhydrazone] on Amyloid Precursor Protein Processing (1999)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 72 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Amyloidogenic processing of the β-amyloid precursor protein (APP) has been implicated in the pathology of Alzheimer’s disease. Because it has been suggested that catabolic processing of the APP holoprotein occurs in acidic intracellular compartments, we studied the effects of the protonophore carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP) and the H+-ATPase inhibitor bafilomycin A1 on APP catabolism in human embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP. Unlike bafilomycin A1, which inhibits β-amyloid production in cells expressing mutant but not wild-type APP, FCCP inhibited β-amyloid production in both cell types. Moreover, the effects of FCCP were independent of alterations in total cellular APP levels or APP maturation, and the concentrations used did not alter either cellular ATP levels or cell viability. Bafilomycin A1, which had no effect on β-amyloid production in wild-type cells, inhibited endocytosis of fluorescent transferrin, whereas concentrations of FCCP that inhibited β-amyloid production in these cells had no effect on endosomal function. Thus, in wild-type-expressing cells it appears that the β-amyloid peptide is not produced in the classically defined endosome. Although bafilomycin A1 decreased β-amyloid release from cells expressing mutant APP but not wild-type APP, it altered lysosomal function in both cell types, suggesting that in normal cells β-amyloid is not produced in the lysosome. Although inhibition of β-amyloid production by bafilomycin A1 in mutant cells may occur via changes in endosomal/lysosomal pH, our data suggest that FCCP inhibits wild-type β-amyloid production by acting on a bafilomycin A1-insensitive acidic compartment that is distinct from either the endosome or the lysosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.721457.x
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