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  • 1
    Electronic Resource
    Electronic Resource
    3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies (1991)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 34 (1991), S. 2557-2560 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00112a033
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  • 2
    Electronic Resource
    Electronic Resource
    Controlled spontaneous emission of a tri(8-hydroxyquinoline) aluminum layer in a microcavity (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 3032-3037 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report the fabrication of all-dielectric microcavities with a tri(8-hydroxyquinoline) aluminum (Alq3) organic layer as the emitting layer. In a first step, we characterized the materials used in the structures by ellipsometry, and ensured nondegradation of the organic material in the fabrication process. Then, by angular-resolved photoluminescence, we investigated changes in the angular emission pattern caused by the cavities and observed a sharply directed emission. We also investigated the influence of the position of the radiative layer in the cavity on normal spontaneous emission. We observed enhancements in spontaneous emission over 20 times higher than that of a single Alq3 layer. These are the highest reported for organic material based microcavities. They are mainly explained by the very small thickness of the Alq3 layer (20 nm≡0.06λ, λ being the resonant wavelength), by high-quality low-loss dielectric mirrors as well as by the narrow collecting angle of our experiment (±3°). This study corroborates analogous works and demonstrates the possibility of controlling the spontaneous emission of an emitter by a microcavity. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.369639
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  • 3
    Electronic Resource
    Electronic Resource
    Gas-phase basicity and site of protonation of polyfunctional molecules of biological interest: FT-ICR experiments and AM1 calculations on nicotines, nicotinic acid derivatives, and related compounds (1991)
    s.l. : American Chemical Society
    The @journal of organic chemistry 56 (1991), S. 4490-4494 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00014a031
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  • 4
    Electronic Resource
    Electronic Resource
    "Gas-phase-like" behavior in solution chemistry (1991)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 7489-7493 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00020a006
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coii (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 13 (1994), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The sequence encompassing the cai genes of Escherichia coli, which encode the carnitine pathway, has been determined. Apart from the already identified caiB gene coding for the carnitine dehydratase, five additional open reading frames were identified. They belong to the caiTABCDE operon, which was shown to be located at the first minute on the chromosome and transcribed during anaerobic growth in the presence of carnitine. The activity of carnitine dehydratase was dependent on the CRP regulatory protein and strongly enhanced in the absence of a functional H-NS protein, in relation to the consensus sequences detected in the promoter region of the cai operon. In vivo expression studies led to the synthesis of five polypeptides in addition to CaiB, with predicted molecular masses of 56 613 Da (CaiT), 42 564 Da (CaiA), 59311 Da (CaiC), 32 329 Da (CaiD) and 21 930 Da (CaiE). Amino acid sequence similarity or enzymatic analysis supported the function assigned to each protein. CaiT was suggested to be the transport system for carnitine or betaines, CaiA an oxidoreduction enzyme, and CaiC a crotonobetaine/carnitine CoA ligase. CaiD bears strong homology with enoyl hydratases/isomerases. Overproduction of CaiE was shown to stimulate the carnitine racemase activity of the CaiD protein and to markedly increase the basal level of carnitine dehydratase activity. It is inferred that CaiE is an enzyme involved in the synthesis or the activation of the still unknown cofactor required for carnitine dehydratase and carnitine racemase activities. Taken together, these data suggest that the carnitine pathway in E. coli resembles that found in a strain situated between Agrobacterium and Rhizobium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x
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  • 6
    Electronic Resource
    Electronic Resource
    The nik operon of Escherichia coli encodes a periplasmic binding-protein-dependent transport system for nickel (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 9 (1993), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The complete nucleotide sequence of the Escherichia coli nik locus, which has been suggested to encode the specific transport system for nickel, has been determined. It was found to contain five overlapping open reading frames that form a single transcription unit. Deduced amino acid sequence of the nik operon shows that its five gene products, NikA to NikE, are highly homologous to components of oligopeptide-and dipeptide-binding protein-dependent transport systems from several Gram-negative and Gram-positive species. NikA represents the periplasmic binding protein, NikB and NikC are similar to integral membrane components of periplasmic permeases, and NikD and NikE possess typical ATP-binding domains that suggest their energy coupling role to the transport process. Insertion mutations in nik genes totally abolished the nickel-containing hydrogenase activity under nickel limitation and markedly altered the rate of nickel transport. Taken together, these data support the notion that the nik operon encodes a typical periplasmic binding-protein-dependent transport system for nickel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1993.tb01247.x
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  • 7
    Electronic Resource
    Electronic Resource
    Positive co-regulation of the Escherichia coli carnitine pathway cai and fix operons by CRP and the CaiF activator (1999)
    Oxford BSL : Blackwell Science Ltd
    Molecular microbiology 34 (1999), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Activation of the two divergent Escherichia coli cai and fix operons involved in anaerobic carnitine metabolism is co-dependent on the cyclic AMP receptor protein (CRP) and on CaiF, the specific carnitine-sensitive transcriptional regulator. CaiF was overproduced using a phage T7 system, purified on a heparin column and ran as a 15 kDa protein on SDS–PAGE. DNase I footprinting and interference experiments identified two sites, F1 and F2, with apparently comparable affinities for the binding of CaiF in the cai–fix regulatory region. These sites share a common perfect inverted repeat comprising two 11 bp half-sites separated by 13 bp, and centred at −70 and −127 from the fix transcription start site. They were found to overlap the two low-affinity binding sites, CRP2 and CRP3, determined previously for CRP. Gel shift assays and footprinting experiments suggest that CaiF and CRP bind co-operatively to the F1/CRP2 and F2/CRP3 sites of the intergenic cai–fix region. Moreover, they appeared to serve the simultaneous binding of each other, giving rise to an original multiprotein CRP–CaiF complex enabling RNA polymerase recruitment and local DNA untwisting, at least at the fix promoter. Using random mutagenesis, two CaiF mutants impaired in transcription activation were isolated. The N-terminal A27V mutation affected the structural organization of the activator, whereas the central I62N mutation was suggested to interfere with DNA binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.1999.01622.x
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  • 8
    Electronic Resource
    Electronic Resource
    Absence of circadian rhythm in the disposition of melatonin in the cow (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 15 (1993), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Five adult pasture-bred Prim Holstein cows were used to document the time invariance of melatonin disposition in the cow. Melatonin was administered by an intravenous route as a bolus (5 μg/kg of body weight) at either 1430 or 2230. Data were analysed according to a three-compartment open model with melatonin elimination from the central compartment. The mean (±SD) kinetic parameters describing melatonin disposition, during day and night, respectively, were plasma clearances: 0.0267 ± 0.0084 1/kg per min and 0.0229 ±0.0031 1/kg per min; steady state volume of distribution: 0.826 ±0.229 1/kg and 0.780 ±0.193 1/kg; terminal half lives: 58.9 ±23.7 min and 64.1 ±33.7 min; mean residence times: 32.0 ±8.8 min and 33.9 ±6.2 min. No statistical difference was found between diurnal and nocturnal values for these parameters. These results support the concept of time invariance for melatonin kinetics in cattle and validate the use of diurnal experiments for the study of melatonin kinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1993.tb00521.x
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  • 9
    Electronic Resource
    Electronic Resource
    Crystal structures of baclofen analogs: 3-thienyl- and 3-furylaminobutyric acids (1993)
    Springer
    Journal of chemical crystallography 23 (1993), S. 843-848 
    Details
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract X-ray crystal structures of 4-amino-3-(2-thienyl) butyric acid (compound1), 4-amino-3-(4-bromo-2-thienyl) butyric acid (compound2), and 4-amino-3-(5-methyl-2-furyl) butyric acid (compound3) are reported. Space groups and unit/cell parameters are: compound1, monoclinic,P21 c,a=13.288(3),b=5.231(1),c=12.388(2)Å,β=92.3(1)°; compound2, monoclinic,P21/c,a=12.610(7),b=5.156(1),c=15.814(8)Å,β=101.8(1)°; compound3, orthorhombic, Pccn,a=11.461(1),b=25.284(2),c=6.977(1)Å. FinalR indices are: compound1, 0.057; compound2, 0.069; compound3, 0.060. Conformations of their γ-aminobutyric chains are compared with the one of γ-amino-β-(p-chlorophenyl)-butyric acid (baclofen, compound4). Two different types of conformations are observed, i.e., conformations (i) with folding (compound3) or (ii) without folding (compounds1,2, and4) of the ammonium group toward the heteroaromatic or aromatic ring. However, distances between ionized groups are constant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01195730
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  • 10
    Electronic Resource
    Electronic Resource
    Coelioscopic cholecystectomy: Experience with 2006 cases (1995)
    Springer
    World journal of surgery 19 (1995), S. 748-752 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cette étude rétrospective porte sur 2006 cholécystectomies laparoscopiques (CL) réalisées par trois chirurgiens «seniors» entre Avril 1988 et Décembre 1992, en utilisant la technique dite «Française» et une cholangiographique peropératoire (CPO) sélective. Trois cent dix huit patients (15.8%) étaient obèses, 75 (3.7%) avaient une insuffisance respiratoire, 251 (12.6%) une inflammation, et 83 (4.1%), une lithiase de la voie biliaire principale (VBP). Ces trois dernières conditions ne sont plus des contre-indications de la CL. Une conversion a été nécessaire chez 43 patients (2.14%). Le taux de complications a été de 2%, 25 (1.25%) non biliaires et 15 (0.7%) biliaires alors qu'il y a eu un décès. La CPO ne prévient pas les complications biliaires puisqu'aucune complication dans cette série n'a été reconnue ou évitées par la CPO. Dans notre expérience, la CPO n'est indiquée que pour localiser des calculs chez le patient présentant des facteurs de risque de lithiase. Le traitement de lithiase de la VBP sous laparoscopie reste controversé.
    Abstract: Resumen Este es un estudio retrospectivo de 2.006 colecistectomías laparoscópicas (CL) con colangiografía intraoperatoria selectiva (CIS) practicadas entre abril de 1988 y diciembre de 1992 por los mismos tres cirujanos senior, utilizando la técnica francesa. Se registró obesidad en 318 pacientes (15.8%), insuficiencia respiratoria en 75 (3.7%), inflamación en 251 (12.6%), y coledocolitiasis en 83 (4.1%). En la actualidad tales alteraciones representan buena indicación para CL. La conversión a laparotomía fue necesaria en 43 casos (2.14%). La tasa de complicaciones fue 2%, de las cuales 25 (1.25%) fueron complicaciones no biliares y 15 (0.7%) estuvieron fueron relacionadas con la vía biliar; se registró una muerte. La CIS no resulta eficaz en cuanto a prevenir complicaciones biliares, puesto que no habría reconocido o evitado a aquellas observadas en esta experiencia. La CIS se practica en forma selectiva solamente con el propósito de identificar cálculos no sospechados en aquellos pacientes de alto riesgo de coledocolitiasis. El tratamiento laparoscópico de la coledocolitiasis continúa siendo motivo de controversia.
    Notes: Abstract 2006 laparoscopic cholecystectomies (LC) were performed from April 1988 to December 1992 by three senior surgeons using the French technique and selective intraoperative cholangiography (IOC). Obesity was present in 318 patients (15.8%), respiratory insufficiency in 75 (3.7%), inflammation in 251 (12.5%), and common bile duct (CBD) stones in 83 (4.1%). The presence of these additional ailments is a good indication for L.C. Conversion to laparotomy occurred in 43 cases (2.1%). The rate of complications was 2%; 25 (1.25%) were nonbiliary complications and 15 (0.7%) were biliary-related; there was one death. IOC is not effective in preventing biliary complications, as those observed in this study would not have been recognized or avoided by it. IOC is carried out only selectively to locate unsuspected stones in patients with risk factors of CBD lithiasis. Laparoscopic treatment of CBD stones is still controversial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295921
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