ISSN:
1432-0533
Schlagwort(e):
Stress-response protein
;
Heat-shock protein
;
Brain tumors
;
Breast tumor metastases
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary This report concerns the expression of the low molecular weight stress-response (heat-shock) protein 27 (srp 27) in a variety of human brain tumors. Immunohistochemical techniques were used; cells of the breast cancer line MCF7 served as positive controls. The reaction product was found exclusively in the cytoplasm. Srp 27 was detected in 5/5 breast tumor metastases to the brain and in 5/21 meningiomas. The protein was also detected in 5/11 glioblastomas and 2/5 pituitary adenomas. By comparison, positive staining was observed in only 1/15 astrocytomas and 1/7 medulloblastoma and no reaction was seen with the oligodendrogliomas, schwannomas and gangliogliomas tested. These observations demonstrate that srp 27 is expressed by certain primary intracranial tumors.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00713535
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