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  • 1
    Electronic Resource
    Electronic Resource
    HIV Infection and Pathogenesis: What About Chemokines? (1999)
    Springer
    Journal of clinical immunology 19 (1999), S. 293-299 
    Details
    ISSN: 1573-2592
    Keywords: HIV ; HIV infection ; HIV pathogenesis ; chemokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several chemotactic cytokines, or chemokines, inhibit HIV replication by blocking or down regulating chemokine receptors that serve as entry cofactors for the virus. Although the role of chemokine receptors in HIV pathogenesis has been the subject of intense interest, chemokines are comparatively less seriously considered as potential correlates of protection from HIV infection and disease progression. However, a critical analysis of newly available data reveals substantial evidence to support a beneficial role for chemokines in HIV infection and disease. In this review we summarize the results of such studies and their promising implications for HIV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020539524373
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chemokine Receptors and Chemokines in HIV Infection (1998)
    Springer
    Journal of clinical immunology 18 (1998), S. 243-255 
    Details
    ISSN: 1573-2592
    Keywords: HIV ; chemokines ; chemokine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Suppression of HIV by chemokines represents a special case in virology and immunology where soluble molecules other than antibodies inhibit infection by a specific virus. The basis for this inhibition is that HIV has evolved to use certain chemokine receptors as “coreceptors” for entry into host cells. Human genotypes that reduce or prevent coreceptor expression are strongly associated with protection against infection and slower disease progression. We suggest that local production of certain chemokines can produce a similar modulation of coreceptor expression, and mounting evidence indicates that chemokine release is a major determinant of protection from HIV infection. Here we review this evidence and explore future avenues for investigating the role of chemokines in controlling HIV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027329721892
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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