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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Intravenous Clarithromycin on Interdigestive Gastroduodenal Motility of Patients with Functional Dyspepsia and Helicobacter pylori Gastritis (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 2439-2442 
    Details
    ISSN: 1573-2568
    Keywords: CLARITHROMYCIN ; HELICOBACTER PYLORI ; GASTROINTESTINAL MOTILITY ; MANOMETRY ; MIGRATING MOTOR COMPLEX ; PROKINETIC DRUGS ; STOMACH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastroduodenal motility of 16 patientscomplaining of functional dyspepsia and Helicobacterpylori gastritis was recorded by means of alow-compliance manometric system with four recordingports in the stomach and four in the duodenum.Clarithromycin (CLA) 250 mg (group A: 8 patients) ornormal saline solution (group B: 8 patients) was infusedintravenously randomly and in double-blind manner 30 minafter the end of the first recorded activity front(AF) of the migrating motor complex or, in the absenceof AFs, after 200 min of recording, continuing therecording until an AF was observed during the subsequent 200 min. CLA administration was followed by atypical gastroduodenal AF in a significantly highernumber of patients than saline administration. Inaddition, the time-lag between the drug administration and the appearance of AFs was 22 min ±7.4 (mean ± SD), significantly shorter than aftersaline (109 ± 56 min) and the CLA-relatedduodenal AFs showed a duration of 7.4 min ± 1.6in group A, significantly longer than that of the spontaneous AFs (3.5min ± 1), while in group B AF duration aftersaline was not significantly different from that of thespontaneous ones. In conclusion, clarithromycin is able to stimulate cyclic interdigestivegastroduodenal motility. This prokinetic property ofclarithromycin is not unexpected because it is amacrolide like erythromycin, the prokinetic activity ofwhich is well known, and could be utilized fortherapeutic uses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026674719476
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  • 2
    Electronic Resource
    Electronic Resource
    Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 1066-1073 
    Details
    ISSN: 1573-2568
    Keywords: nonulcer dyspepsia ; migrating motor complexes ; bile salt concentration ; gastric emptying
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 11 children (mean age 44.2 months) with symptoms suggesting upper intestinal dysfunction (nonulcer dyspepsia), in nine children (mean age 27.3 months) with gastroesophageal reflux (GER) disease, and in seven controls (mean age 20.4 months) we investigated fasting [for 3 hr or until two migrating motor complexes (MMC) were observed] and fed (90 min) antroduodenal motility by means of perfused catheter system; furthermore, we measured both gastric emptying of a radiolabeled milk formula and fasting duodenogastric reflux during manometry by assessing bile salt concentration in gastric aspirates. No structural abnormalities of gastrointestinal tract and organic disorders were detected in the patients. In a high proportion of both groups of patients we found manometric abnormalities of interdigestive and fed motor patterns that were not seen in the controls: absence of antral phase III of MMC; significant decrease of antral and/or duodenal motor activity during fasting and/or fed periods; abnormal propagation or configuration of MMC phase III that was signficantly shorter than in controls; bursts of sustained fasting and/or fed phasic duodenal activity, frequently uncoordinated with adjacent gut segments. When compared to controls, the mean intragastric concentration of bile salts during all MMC phases and the mean 1-hr percent gastric activity of the radiolabeled milk were significantly higher in the two groups of patients. We conclude that in a high proportion of children with nonulcer dyspepsia and of children with GER disease, gastrointestinal manometry may reveal significant irregularities of antral and duodenal motility, which are associated with increased duodenogastric reflux and delayed gastric emptying.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297448
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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