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  • 1995-1999  (5)
  • 1990-1994  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Human Brain βA4 Amyloid Protein Precursor of Alzheimer's Disease: Purification and Partial Characterization (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The major component of the amyloid deposition that characterizes Alzheimer's disease is the 4-kDa βA4 protein, which is derived from a much larger amyloid protein precursor (APP). A procedure for the complete purification of APP from human brain is described. The same amino terminal sequence of APP was found in two patients with Alzheimer's disease and one control subject. Two major forms of APP were identified in human brain with apparent molecular masses of 100–110 kDa and 120–130 kDa. Soluble and membrane fractions of brain contained nearly equal amounts of APP in both humans and rats. Immunoprecipitation with carboxyl terminus-directed antibodies indicates that the soluble forms of APP are truncated. Carboxyl terminus truncation of membrane-associated forms of human brain APP was also found to occur during postmortem autolysis. The availability of purified human brain APP will facilitate the investigation of its normal function and the events that lead to its abnormal cleavage in patients with Alzheimer's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb08465.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease (1991)
    s.l. : American Chemical Society
    Biochemistry 30 (1991), S. 10795-10799 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00108a027
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells (1996)
    [s.l.] : Nature Publishing Group
    Nature medicine 2 (1996), S. 224-229 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Mutations in two recently identified genes appear to cause the majority of early–onset familial Alzheimer's disease (FAD). These two novel genes, presenilin 1 (PS1) and presenilin 2 (PS2) are members of an evolutionarily conserved gene family. The normal biological role(s) of the presenilins ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0296-224
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A Monte Carlo Analysis of the Fisher Randomization Technique: Reviving Randomization for Experimental Economists (1998)
    Springer
    Experimental economics 1 (1998), S. 87-100 
    Details
    ISSN: 1573-6938
    Keywords: Randomization test ; Monte Carlo simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Data created in a controlled laboratory setting are a relatively new phenomenon to economists. Traditional data analysis methods using either parametric or nonparametric tests are not necessarily the best option available to economists analyzing laboratory data. In 1935, Fisher proposed the randomization technique as an alternative data analysis method when examining treatment effects. The observed data are used to create a test statistic. Then treatment labels are shuffled across the data and the test statistic is recalculated. The original statistic can be ranked against all possible test statistics that can be generated by these data, and a p-value can be obtained. A Monte Carlo analysis of t-test, the Mann-Whitney U-test, and the exact randomization t-test is conducted. The exact randomization t-test compares favorably to the other two tests both in terms of size and power. Given the limited distributional assumptions necessary for implementation of the exact randomization test, these results suggest that experimental economists should consider using the exact randomization test more often.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009961917752
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Heterogeneity and the Voluntary Provision of Public Goods (1999)
    Springer
    Experimental economics 2 (1999), S. 5-30 
    Details
    ISSN: 1573-6938
    Keywords: public goods ; voluntary provision ; heterogeneous agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract We investigate the effects of heterogeneity and incomplete information on aggregate contributions to a public good using the voluntary contribution mechanism. The non-linear laboratory environment has three-person groups as partners under varying conditions of information and communication. Bergstrom, Blum and Varian predict that increasing heterogeneity will have no effect on aggregate contributions in a no-communication environment. Ledyard conjectures a positive effect of incomplete information, a negative effect of heterogeneity, and a positive interaction of heterogeneity and incomplete information. We find that incomplete information has a small but significant negative effect. Heterogeneity has a positive effect on aggregate contributions, but its effects interact unexpectedly with communication. In a no-communication environment, heterogeneity in two dimensions (endowment and preferences) increases contributions substantially while heterogeneity in a single dimension (endowment or preferences) has little effect. In the communication environment we find the reverse. We also find a positive interaction between heterogeneity and incomplete information. Thus we reject the Bergstrom, Blume and Varian invariance result and provide mixed evidence on Ledyard's conjectures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009984414401
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Heterogeneity and the voluntary provision of public goods (1999)
    Springer
    Experimental economics 2 (1999), S. 5-30 
    Details
    ISSN: 1573-6938
    Keywords: public goods ; voluntary provision ; heterogeneous agents ; H41 ; C92
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract We investigate the effects of heterogeneity and incomplete information on aggregate contributions to a public good using the voluntary contribution mechanism. The non-linear laboratory environment has three-person groups as partners under varying conditions of information and communication. Bergstrom, Blum and Varian predict that increasing heterogeneity will have no effect on aggregate contributions in a no-communication environment. Ledyard conjectures a positive effect of incomplete information, a negative effect of heterogeneity, and a positive interaction of heterogeneity and incomplete information. We find that incomplete information has a small but significantnegative effect. Heterogeneity has apositive effect on aggregate contributions, but its effects interact unexpectedly with communication. In a no-communication environment, heterogeneity in two dimensions (endowment and preferences) increases contributions substantially while heterogeneity in a single dimension (endowment or preferences) has little effect. In the communication environment we find the reverse. We also find a positive interaction between heterogeneity and incomplete information. Thus we reject the Bergstrom, Blume and Varian invariance result and provide mixed evidence on Ledyard's conjectures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01669132
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    A Monte Carlo analysis of the fisher randomization technique: Reviving randomization for experimental economists (1998)
    Springer
    Experimental economics 1 (1998), S. 87-100 
    Details
    ISSN: 1573-6938
    Keywords: Randomization test ; Monte Carlo simulation ; C15 ; C90
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Data created in a controlled laboratory setting are a relatively new phenomenon to economists. Traditional data analysis methods using either parametric or nonparametric tests are not necessarily the best option available to economists analyzing laboratory data. In 1935, Fisher proposed the randomization technique as an alternative data analysis method when examining treatment effects. The observed data are used to create a test statistic. Then treatment labels are shuffled across the data and the test statistic is recalculated. The original statistic can be ranked against all possible test statistics that can be generated by these data, and ap-value can be obtained. A Monte Carlo analysis oft-test, the Mann-WhitneyU-test, and the exact randomizationt-test is conducted. The exact randomizationt-test compares favorably to the other two tests both in terms of size and power. Given the limited distributional assumptions necessary for implementation of the exact randomization test, these results suggest that experimental economists should consider using the exact randomization test more often.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01426216
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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