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  • 1
    Electronic Resource
    Electronic Resource
    Mammalian heat shock protein families. Expression and functions (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 629-634 
    Details
    ISSN: 1420-9071
    Keywords: Heat shock proteins (hsp) ; chaperones ; protein degradation ; ubiquitin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract When prokaryotic or eukaryotic cells are submitted to a transient rise in temperature or to other proteotoxic treatments, the synthesis of a set of proteins called the heat shock proteins (hsp) is induced. The structure of these proteins has been highly, conserved during evolution. The signal leading to the transcriptional activation of the corresponding genes is the accumulation of denatured and/or aggregated proteins inside the cells after stressful treatment. The expression of a subset of hsp is also induced during early embryogenesis and many differentiation processes. Two different functions have been ascribed to hsp: - a molecular chaperone function: chaperones mediate the folding, assembly or translocation across the intracellular membranes of other polypeptides, and - a role in protein degradation: some of the essential components of the cytoplasmic ubiquitin-dependent degradative pathway are hsp. These functions of hsp are essential in every living cell. They are required for repairing the damage resulting from stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02118307
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    HSP gene expression and HSF2 in mouse development (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 179-190 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Chaperones; heat shock proteins; heat shock transcription factors; pre- and post-implantation development.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. During the pre-implantation phase of development, the mouse embryo synthesizes HSC70, and HSP90α and β at a very high rate. After implantation, the expression of HSPs appears non-coordinated and is not uniform in the different tissues. The expression of inducible HSPs appears later in development than that of constitutive members of the family. HSP25 is highly expressed early in heart and muscle development, but also in some structure of the central nervous system. HSC70 and HSP90β are expressed ubiquitously, but their expression reaches very high levels in the nervous system (neural tracks) and during bone morphogenesis (in the hypertrophic chondrocytes). The mechanisms involved in HSP expression during mouse embryogenesis are probably diverse, involving tissue-specific sequences. Although the DNA-binding activity and expression of the second heat shock transcription factor, HSF2, seems to be developmentally regulated, becoming detectable at the blastocyst stage and reaching a peak at day 10 of development, there is no obvious correlation between the level of this factor and the expression of HSPs. HSF2 might be involved in the onset of expression of HSPs, regulate (inhibit) their expression, or control the expression of other developmental genes yet to be discovered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000590
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    Paper (German National Licenses)
    Fulltext
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