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  • 1995-1999  (1)
  • 1990-1994  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of ranitidine on acetaminophen-induced hepatotoxicity in dogs (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 385-391 
    Details
    ISSN: 1573-2568
    Keywords: hepatotoxicity ; acetaminophen ; ranitidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of ranitidine administration upon the hepatotoxic effect produced by a multidose acetaminophen administration regimen was examined. Seventy-two dogs received three subcutaneous injections of acetaminophen (750, 200, 200 mg/kg body wt) in DMSO (600 mg/ml) at time zero, 9 hr later, and 24 hr after the first dose. Ten control animals (group I) were not given ranitidine, the remaining 62 dogs received an intramus-cular injection of ranitidine 30 min before each acetaminophen dose. Three different doses of ranitidine were used (mg/kg body wt): 50 mg, group II (33 dogs); 75 mg, group III (14 dogs); 120 mg, group IV (15 dogs). Ranitidine reduced the expected acetaminophen-induced hepatoxicity in a dose-response manner. Moreover, a significant correlation was found between the ranitidine dose and the survival rate, as evidenced by transaminase levels in the serum and histology of the liver. This model of fulminant hepatic failure induced by acetaminophen and its modulation with ranitidine provides clinical investigators with a research tool that will be useful in the future investigation of putative medical and surgical therapies being investigated for use in the clinical management of fulminant hepatic failure. Because of the size of the animal used in this model, frequent and serial analyses of blood and liver were available for study to determine the effect of therapy within a given animal as opposed to within groups of animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537419
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    An integrated system for forecasting Arno River flash floods (1992)
    Springer
    Natural hazards 5 (1992), S. 179-197 
    Details
    ISSN: 1573-0840
    Keywords: Flood hazard ; risk forecasting ; expert systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A system for effectively forecasting flash floods of the Arno River (Tuscany, Italy) should provide a flood warning with 10–12 h of lead time, primarily in order to evacuate the city of Florence. This goal may be achieved by acquiring and processing meteorological and hydrological data in real-time and, accordingly, by releasing alarms at different levels of reliability and concern. Through the application of both procedural language and expert system techniques, a prototype was developed which can readily handle a variety of relevant information and make predictions on flood hazard in Florence. The system was fairly successfully tested by processing simple meteorological data which enable a 24 hour forewarning to be released.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00127005
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Experimental snap-through boundaries for acoustically excited, thermally buckled plates (1996)
    Springer
    Experimental mechanics 36 (1996), S. 312-317 
    Details
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper presents some recent experimental results on the dynamic snap-through behavior of a clamped, rectangular plate subject to thermal loading and intense acoustic excitation. The likelihood of snap-through oscillations is characterized in terms of boundaries separating regions of snap-through and no snap-through in the parameter space. Two scenarios are considered. First, using tonal inputs, the regions of snap-through are mapped in the sound pressure level—input frequency domain ((SPL, ω) plane). Second, random acoustic inputs are used, and the effect of varying the overall sound pressure level and frequency bandwidth are investigated ((SPL, $$\omega _{center} + \bar \omega $$ ) plane). Several nonlinear characteristics are evident and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02328572
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    Paper (German National Licenses)
    Fulltext
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