ISSN:
1573-0832
Keywords:
Aspergillus parasiticus ATCC 36537
;
enzyme induction
;
mannitol dehydrogenase
;
mannitol-1-phosphate dehydrogenase
;
NADPH/NADP ratio
;
nitrate reductase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Addition of sodium nitrate to growing cultures ofAspergillus parasiticus (ATCC 36537) induces the synthesis of enzymes involved in nitrate assimilation (NO 3 − reductase), of enzymes in the pentose pathway (glucose-6-phosphate dehydrogenase), and of enzymes in the mannitol cycle (mannitol- and mannitol-1-phosphate dehydrogenases). Addition of NO 3 − also causes a dose-dependent suppression of synthesis of the polyketide secondary metabolite, versicolorin A. We suggest that in the presence of NO 3 − plus peptone, the cytoplasmic NADPH/NADP ratio may be elevated, resulting in increased conversion of malonyl coenzyme A to fatty acid rather than to polyketide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00707550
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